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Altération de la physiologie des poissons exposés à des hydrocarbures aromatiques polycycliques (HAP). Comportement et reproduction ArchiMer
Vignet, Caroline.
Polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants (POPs) which are found in complex mixtures in the environment including aquatic ecosystems. They adsorb on particles, accumulate in sediment and in the first link of the food web. The aim of this study was to measure long term effects of PAH scontamination on a vertebrate model: the zebrafish. In a first study, embryos were exposed on natural sediment spiked with 3 individual PAH (phenanthrene, pyrene and benzo[a]pyrene) during the first four days of their development. In a second study, to evaluate the consequences of long-term chronic exposure to PAHs, zebrafish were exposed, from their first meal (5 days post fertilisation) until they became reproducing adults, to diets spiked...
Tipo: Text Palavras-chave: Danio rerio; Lifecycle; Polycyclic aromatic hydrocarbon; Heavy oil; Light crude oil; Alkylated PAH; Lifecycle; Delayed effect; Anxiety-like behavior; Offspring; Photomotor responses; Maze; Novel tank..
Ano: 2014 URL: http://archimer.ifremer.fr/doc/00195/30598/29052.pdf
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Both Hepatic Lipogenesis and Beta-Oxidation are Altered in Offspring of Mothers Fed a High-Fat Diet in the First Two Generations (F1 and F2) International Journal of Morphology
Lannes,Wilian Rodrigues; Miranda,Andressa Cabral de; Souza-Mello,Vanessa de; Barbosa-da-Silva,Sandra; Aguila,Marcia Barbosa; Mandarim-de-Lacerda,Carlos Alberto.
The high fat (HF) fed mothers may program susceptibility in offspring to chronic diseases and affect subsequent generations. The present study evaluated the liver structure in adulthood, focusing on the F1 and F2 generations. Females C57BL/6 (F0) were fed standard chow (SC) or HF diet (8 weeks) prior to mating and during the gestation and lactation to provide the F1 generation (SC-F1 and HF-F1). All other mothers and offspring fed SC. At 3 months old, F1 females were mated to produce the F2 generation (SC-F2 and HF-F2). The liver was kept in several fragments and prepared for histological analysis or frozen for biochemical and molecular analyzes. The F1 and F2 offspring were studied at 3 months old. HF-F1 had higher body mass (BM) compared to SC-F1 (P=...
Tipo: Journal article Palavras-chave: High-fat diet; Hepatic lipogenesis; Beta-oxidation; Maternal obesity; Offspring.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400052
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Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age Anais da ABC (AABC)
CORVINO,SILVANA B.; DAMASCENO,DÉBORA C.; SINZATO,YURI K.; NETTO,ALINE O.; MACEDO,NATHÁLIA C.D.; ZAMBRANO,ELENA; VOLPATO,GUSTAVO T..
ABSTRACT The aim of this study was to compare two models of swimming applied to pregnant rats born small for pregnancy age (SPA). Diabetes was chemically induced in adult female rats to develop an inadequate intrauterine environment, leading to birth of a SPA offspring. In adulthood, the female SPA rats were mated and submitted to different swimming programs. The exercise program 1 (Ex1) consisted of swimming for 15 minutes, followed by 15 minutes of rest and another 15 minutes of swimming, 3 days a week before and during pregnancy. Another program (Ex2) was applied during 60 minutes uninterrupted a day, 6 days/week during pregnancy. The pregnant rats presented no interference on body weight and glycemia. The rats submitted to Ex2 model showed decreased...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rats; Diabetes; Pregnancy; Offspring; Exercise..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100223
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Effect of obesity on rat reproduction and on the development of their adult offspring BJMBR
Campos,K.E.; Volpato,G.T.; Calderon,I.M.P.; Rudge,M.V.C.; Damasceno,D.C..
The aim of the present study was to assess the reproductive parameters of obese Wistar rats and to determine the frequency of their obese adult offspring. Neonatal rats were divided into two groups: F1 generation, induced to obesity by monosodium glutamate (MSG; F1MSG, N = 30), and rats given saline (F1CON, N = 13). At 90 days of age all animals were mated, producing the F2 offspring (F2CON, N = 28; F2MSG, N = 15). Reproductive parameters (fertility, pregnancy, and delivery indexes) were evaluated in F1 rats. F2 newborns were weighed, and the obesity parameter for F1 and F2 generations was determined from months 5 to 7 of life. At month 7, periovarian fat was weighed and no differences were found. Mean newborn weight also did not differ. The F1 and F2MSG...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Obesity; Offspring; Fertility; Wistar rats; Monosodium glutamate; Transgeneration.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200008
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Exposures of zebrafish through diet to three environmentally relevant mixtures of PAHs produce behavioral disruptions in unexposed F1 and F2 descendant ArchiMer
Vignet, Caroline; Joassard, Lucette; Lyphout, Laura; Guionnet, Tiphaine; Goubeau, Manon; Le Menach, Karyn; Brion, Francois; Kah, Olivier; Chung, Bon-chu; Budzinski, Helene; Begout, Marie-laure; Cousin, Xavier.
The release of polycyclic aromatic hydrocarbons (PAHs) into the environment has increased very substantially over the last decades. PAHs are hydrophobic molecules which can accumulate in high concentrations in sediments acting then as major secondary sources. Fish contamination can occur through contact or residence nearby sediments or though dietary exposure. In this study, we analyzed certain physiological traits in unexposed fish (F1) issued from parents (F0) exposed through diet to three PAH mixtures at similar and environmentally relevant concentrations but differing in their compositions. For each mixture, no morphological differences were observed between concentrations. An increase in locomotor activity was observed in larvae issued from fish...
Tipo: Text Palavras-chave: Danio rerio; Polycyclic aromatic hydrocarbon; Offspring; Transgenerational effect; Heavy oil; Light crude oil; Locomotor activity; Photomotor response; Anxiety-like behavior.
Ano: 2015 URL: https://archimer.ifremer.fr/doc/00259/37030/35688.pdf
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Factors influencing in vitro embryo production. Repositório Alice
CAMARGO, L. S. A.; VIANA, J. H. M.; SÁ, W. F. de; FERREIRA, A. M.; RAMOS, A. A.; VALE FILHO, V. R..
In vitro embryo production (IVP) is currently one of the most important biotechnologies in cattle breeding and husbandry. However, the efficiency of in vitro embryo production is still low with only 30-40% of oocytes developing into blastocysts, probably because, the in vitro environment cannot mimic in vivo environment and results in embryos that have altered morphology and gene expression. Several factors can influence the IVP efficiency and contribute to the existing differences between in vivo and in vitro produced embryos. There is also evidence showing that IVP can cause some disorders during gestation and in offspring. The aim of this review is to give a brief overview of some factors that influence in vitro embryo development in cattle.
Tipo: Artigo de periódico Palavras-chave: Bovine; Embryo development; Offspring; In vitro fertilization.
Ano: 2006 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/595919
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Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring International Journal of Morphology
Moharerri,Alireza; Ghafari,Soraya; Golalipour,Mohammad Jafar.
Previous study has shown the adverse effects of gestational diabetes on hippocampal and spinal cord neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on beta cells in rat pancreas in early postnatal life. In this experimental study, 10 dams randomly allocated into control and diabetic groups on day 1 of gestation. Five dams in diabetic group received 40 mg/kg/BW of streptozotocin (intraperitoneally) and control animals received normal saline. Six of 28 and 56-day-old offspring of each gestational diabetes mellitus and controls were randomly scarified and sections were taken from the pancreas and stained using Gomorra's method. The density of beta cells and number and area of pancreatic islets were...
Tipo: Journal article Palavras-chave: Gestational diabetes; Beta cell; Pancreas; Offspring; Rat.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400034
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Hypotrophy of conduit artery walls of the offspring of nitric oxide-defective rats BJMBR
Kristek,F.; Gerová,M..
The objective of the present study was to investigate the structure of the arterial walls of the offspring stemming from nitric oxide (NO)-defective hypertensive parents. The parents were treated with N G-nitro-L-arginine methyl ester (40 mg kg-1 day-1) for 5 weeks. Blood pressure was measured noninvasively in six 30-day-old rats and nine age-matched controls. The cardiovascular system was perfused with glutaraldehyde at 120 mmHg. The thoracic aorta and carotid artery were processed for electron microscopy, and geometry was determined by light microscopy. Endothelial cells, smooth muscle cells (SMC) and extracellular matrix (ECM) were determined by the point counting method in electron micrographs of the carotid artery. The blood pressure of experimental...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Artery; Nitric oxide; Offspring; Hypertension; Vascular smooth muscle; Extracellular matrix; Morphometry.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400018
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Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats Anais da ABC (AABC)
SANTOS,CAROLYNE D.S.; BALBO,SANDRA L.; GUIMARÃES,ANA T.B.; SAGAE,SARA C.; NEGRETTI,FÁBIO; GRASSIOLLI,SABRINA.
ABSTRACT Here, we evaluated whether the exposure of rats to a cafeteria diet pre- and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on standard rodent chow) and Cafeteria (CAF; fed with the cafeteria diet throughout life, including pregnancy and lactation). After birth, only male offspring (F1) were maintained and received the CTL or CAF diets; originating four experimental groups: CTL-CTLF1; CTL-CAFF1; CAF-CTLF1; CAF-CAFF1. Data of biometrics, metabolic parameters, liver, BAT and WAT histology were assessed and integrated using the Principal Component Analysis (PCA). According to PCA analysis worse...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Dams; Offspring; Histology.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602887
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Litter Size Reduction Induces Metabolic and Histological Adjustments in Dams throughout Lactation with Early Effects on Offspring Anais da ABC (AABC)
Xavier,João Lucas P.; Scomparin,Dionizia X.; Pontes,Catherine C.; Ribeiro,Paulo Roberto; Cordeiro,Maiara M.; Marcondes,Jessica A.; Mendonça,Felipe O.; Silva,Makcine T. da; Oliveira,Fabio B. de; Franco,Gilson C.N.; Grassiolli,Sabrina.
In the present study we analyzed morphological and metabolic alterations in dams nursing small litters and their consequences to offspring throughout lactation. Offspring sizes were adjusted to Small Litter (SL, 3 pups/ dam) and Normal Litter (NL, 9 pups/ dam). Body weight, food intake, white adipose tissue (WAT) content, histological analysis of the pancreas, mammary gland (MG) and brown adipose tissue (BAT) as well as, plasma parameters and milk composition were measured in dams and pups on the 7th, 14th and 21st days of lactation. In general, SL-dams presented higher body weight and retroperitoneal fat content, elevated fat infiltration in BAT, reduced islets size and hyperglycemia throughout lactation in relation to NL-dams (p<0.05). Moreover, MG...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dams; Metabolic programming; Milk; Offspring.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100803
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Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment ArchiMer
Vignet, Caroline; Devier, Marie-hélène; Le Menach, Karyn; Lyphout, Laura; Potier, Jeremy; Cachot, Jerome; Budzinski, Helene; Begout, Marie-laure; Cousin, Xavier.
A natural sediment spiked with three individual polycyclic aromatic hydrocarbons (PAHs; pyrene, phenanthrene and benzo[a]pyrene) was used to expose zebrafish embryos and larvae during 4 days. The total PAH concentration was 4.4 μg g−1 which is in the range found in sediment from contaminated areas. Quantification of metabolites in the larvae after exposure confirmed the actual contamination of the larvae and indicated an active metabolism especially for pyrene and benzo[a]pyrene. After a transfer in a clean medium, the larvae were reared to adulthood and evaluated for survival, growth, reproduction, and behavior. Measured endpoints revealed a late disruption of growth (appearing at 5 months) and a trend toward a lower reproductive ability. Adults of...
Tipo: Text Palavras-chave: Danio rerio; Polycyclic aromatic hydrocarbon; Lifecycle; Anxiety-like behavior; Offspring.
Ano: 2014 URL: http://archimer.ifremer.fr/doc/00188/29909/28497.pdf
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Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development BJMBR
Da Costa,N. Meireles; Visoni,S.B.C.; Dos Santos,I.L.; Barja-Fidalgo,T.C.; Ribeiro-Pinto,L.F..
Early nutrition plays a long-term role in the predisposition to chronic diseases and influences the metabolism of several drugs. This may happen through cytochromes P450 (CYPs) regulation, which are the main enzymes responsible for the metabolism of xenobiotics. Here, we analyzed the effects of maternal protein restriction (MPR) on the expression and activity of hepatic offspring’s CYPs during 90 days after birth, using Wistar rats as a mammal model. Hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2 and CYP2E1 mRNA and protein expression, and associated catalytic activities (ECOD, EROD, MROD, BROD, PROD and PNPH) were evaluated in 15-, 30-, 60-, and 90-day-old offspring from dams fed with either a 0% protein (MPR groups) or a standard diet (C groups) during the 10...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Maternal protein restriction; Offspring; CYP; Perinatal nutrition; Metabolic programming.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001100603
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