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Combined effects of diethylpropion and alcohol on locomotor activity of mice: participation of the dopaminergic and opioid systems BJMBR
Gevaerd,M.S.; Sultowski,E.T.; Takahashi,R.N..
The widespread consumption of anorectics and combined anorectic + alcohol misuse are problems in Brazil. In order to better understand the interactive effects of ethanol (EtOH) and diethylpropion (DEP) we examined the locomotion-activating effects of these drugs given alone or in combination in mice. We also determined whether this response was affected by dopamine (DA) or opioid receptor antagonists. A total of 160 male Swiss mice weighing approximately 30 g were divided into groups of 8 animals per group. The animals were treated daily for 7 consecutive days with combined EtOH + DEP (1.2 g/kg and 5.0 mg/kg, ip), EtOH (1.2 g/kg, ip), DEP (5.0 mg/kg, ip) or the control solution coadministered with the DA antagonist haloperidol (HAL, 0.075 mg/kg, ip), the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diethylpropion; Ethanol; Locomotor activity; Dopamine; Opioid; Mice.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200015
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Different rates of tramadol infusion for peri and postoperative analgesia in dogs undergoing orthopedic surgery Arq. Bras. Med. Vet. Zootec.
Oliva,V.N.L.S.; Albuquerque,V.B.; Floriano,B.P.; Meneghetti,T.M.; Abimussi,C.J.X.; Ferreira,J.Z.; Wagatsuma,J.T.; Laranjeira,G.M.; Santos,P.S.P..
ABSTRACT The study aimed to determine the continuous rate infusion of tramadol associated with peri- and postoperative analgesia for orthopedic surgeries in dogs, as well as cardiorespiratory and adverse effects. Thirty dogs aged 4.2±1.2 years and weighing 15.1±0.9kg were enrolled in the study, premedicated intramuscularly with acepromazine (0.04mg kg-1) and tramadol (2mg kg-1); anesthesia was induced with propofol and maintained with isoflurane in oxygen. Three infusion rates were compared, comprising three experimental groups: G2: 2.0mg kg-1 h-1; G2.5: 2.5mg kg-1 h-1; and G3: 3.0mg kg-1 h-1. Surgery was initiated 15 minutes following the start of tramadol infusion. During anesthesia, animals were monitored in predefined time points: immediately after...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dogs; Orthopedics; Analgesia; Opioid.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000100127
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Echocardiographic parameters in dogs treated with acepromazine and fentanyl Arq. Bras. Med. Vet. Zootec.
Santos,E.A.; Aptekmann,K.P.; Santos,P.O.P.R.; Reis,A.C.; Kuster,M.C.C.; Andrade Junior,P.S.C..
ABSTRACT Considering that the use of tranquillizers could optimize the performance of the echocardiogram, this study aimed to evaluate the effect of protocols with acepromazine and fentanyl on the echocardiographic parameters of healthy dogs, besides their effect in systolic blood pressure (SBP), respiratory rate (RR), heart rate (HR), time spent for examination and sedation scale. Ten adult dogs were submitted to different tranquilizing protocols 20 minutes before the echocardiographic examination, totalling five treatments for each pair, performed at seven-day intervals between evaluations. The treatments were CT (control treatment), IAT (intramuscular acepromazine), OAT (oral acepromazine), FT (fentanyl) and AFT (acepromazine associated with fentanyl)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Echocardiography; Phenothiazine; Opioid.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000601767
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Effects of tramadol and acepromazine on intraocular pressure and pupil diameter in young healthy cats Ciência Rural
Schroder,Deise Cristine; Monteiro,Bianca Garay; Pytlak,Deborah Braga; Souza,Mayara Carvalho de; Mendonça,Adriane Jorge; Ribeiro,Alexandre Pinto.
ABSTRACT: This study aimed to investigate the effects of the systemic administration of acepromazine, tramadol and the association of both on intraocular pressure (IOP) and pupil diameter (PD) in young healthy cats. Cats were randomly allocated into three groups (n=10/each) and intramuscular acepromazine (AG), tramadol (TG) or acepromazine combined with tramadol (ATG) were injected. PD (electronic caliper) and IOP (applanation tonometry) were assessed before (baseline) and following 15, 30, 60, and 120 minutes of treatments. It was verified that in AG, PD decreased significantly from time point 30 to 120 (P=0.002), but such reduction did not differ significantly from baseline (P=0.89). In TG, PD increased significantly from the first 15 minutes, until the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Opioid; Phenothiazinic; Mydriasis; Intraocular surgeries; Cats.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000300601
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Effects of tramadol on tear production, intraocular pressure, and pupil size in dogs: clinical study Ciência Rural
Ruiz,Thaís; Peres,Thalita Priscila da Silva; Campos,Wilma Neres da Silva; Sorte,Eveline da Cruz Boa; Ribeiro,Alexandre Pinto.
This study aimed to evaluate the effects of tramadol on tear production, intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs. Dogs were randomly assigned to receive 4mg kg-1 (n=11) and 6mg kg-1 (n=11) of tramadol hydrochloride intramuscularly. Tear production (Schirmer tear test, STT-1), IOP (applanation tonometry) and the PD (electronic pachymetry) were assessed before, 30 and 60 minutes after administration of tramadol. Data were compared by analysis of variance for repeated measures (P<0.05). Parameters evaluated before, at 30 and 60min, in dogs treated with 4 and 6mg kg-1, were respectively: (STT-1) 22.50±3.38, 21.14±3.94 and 21.09±2.99mm min-1; and 23.05±3.73,22.64±3.76 and 22.82±3.25mm min-1. (IOP) 18.14±2.68, 17.68±2.59 and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Opioid; Analgesic; Miosis; Keratoconjunctivitis sicca.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000400724
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Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion Arq. Bras. Med. Vet. Zootec.
Albuquerque,V.B.; Araújo,M.A.; Ferreira,G.T.N.M.; Fonseca,M.W.; Abimussi,C.J.X.; Ferreira,J.Z.; Oliva,V.N.L.S..
The aim of this study was to assess the cardiopulmonary, analgesic, adverse effects, serum concentration of cortisol and plasma levels of levobupivacaine and morphine in bitches undergoing propofol anesthesia and epidural analgesia with levobupivacaine alone or combined with morphine. This was a randomized 'blinded' prospective clinical study using 32 adult bitches weighing 9.8±4.1kg that were admitted for elective ovariohysterectomy. Twenty minutes after administration of acepromazine and midazolam, anesthesia was induced with propofol (4mg kg-1) and maintained by a continuous rate infusion (CRI). Each animal was randomly assigned to one of four epidural groups: GL = levobupivacaine alone (0.33mg kg-1); GLM0.1 = levobupivacaine and morphine (0.1mg kg-1);...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dog; Opioid; Ovariohysterectomy; Blood gas; Regional anaesthesia.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000400951
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Hematologic changes in propofol-anesthetized dogs with or without tramadol administration Arq. Bras. Med. Vet. Zootec.
Costa,P.F.; Nunes,N.; Belmonte,E.A.; Moro,J.V.; Lopes,P.C.F..
Drugs commonly used in anesthesia practice may significantly alter the oxidative state of blood cells. This mechanism could contribute to the immune suppression that occurs transiently in the early postoperative period. Thus, we assessed the effects of continuous rate infusion (CRI) of propofol associated or not with tramadol on hematologic parameters in dogs. Eight adult mongrel dogs were anesthetized on 2 occasions, 15 d apart. Two groups were formed: control group (CG) and tramadol group (GT). Propofol was used for induction (10mg kg-1) followed by a CRI (0.7mg kg-1minute-1). The animals were positioned in lateral recumbency and mechanically ventilated with inspired oxygen fraction of 0.6. In TG, tramadol (2mg kg-1) followed by a CRI (0.5mg...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Blood cells; Hematology; Opioid; Total intravenous anesthesia.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000500007
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Opioidergic orofacial antinociception induced by electroacupuncture at acupoint St36 BJMBR
Almeida,R.T.; Perez,A.C.; Francischi,J.N.; Castro,M.S.; Duarte,I.D.G..
The participation of opioids in the antinociceptive effect of electroacupuncture was evaluated in terms of nociception produced by thermal stimuli applied to the face of male Wistar rats, weighing 180-230 g. Electrical stimulation (bipolar and asymmetric square wave with 0.5 mA intensity for 20 min) of acupoint St36, located in the anterior tibial muscle 10 mm distal to the knee joint, induced antinociception in the present model, which was maintained for 150 min. Acupoint LI4, located in the junction of the first and second metacarpal bones, did not achieve antinociception at any frequency studied (5 Hz: 1.7 ± 0.1; 30 Hz: 1.8 ± 0.1; 100 Hz: 1.7 ± 0.1 vs 1.4 ± 0.2). The antinociception obtained by stimulation of acupoint St36 was only achieved when high...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acupuncture; St36 acupoint; Opioid; Orofacial antinociception.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000700012
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The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats BJMBR
Maegawa,F.A.B.; Tonussi,C.R..
There are only a few studies on the molecular mechanisms underlying the peripheral antihyperalgesic effect of opioids. The aim of this study was to investigate the molecular bases of the peripheral antihyperalgesic effect of fentanyl in a model of prostaglandin-induced chemical hyperalgesia. Prostaglandin E2 (1.4 nmol) injected into one hind paw of male Wistar rats (200-250 g, N = 6 in each experimental or control group) pretreated with indomethacin (2.5 mg/kg) potentiated the nocifensive response to formalin (1%) injection made 60 min later. Drugs applied locally 30 min after prostaglandin E2 induced the following effects: fentanyl (0.1-1.0 nmol) caused a dose-dependent reversal of the hyperalgesic state, naloxone (2 nmol) co-injected with fentanyl (1...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Opioid; Guanylate cyclase; Prostaglandin; PDE5; UK-114; 542-27.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200012
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Tramadol effects on clinical variables and the mechanical nociceptive threshold in horses Ciência Rural
Franco,Leandro Guimarães; Moreno,Juan Carlos Duque; Teixeira Neto,Antônio Raphael; Souza,Moisés Caetano e; Silva,Luiz Antônio Franco da.
This study assessed the clinical effects and the mechanical antinociceptive potential of intravenous (IV) tramadol in horses.A blinded and randomized study was designed with 7 horses treated with 1 (Tr1), 2 (Tr2) or 3 (Tr3) mg kg-1 of tramadol IV. The heart rate, respiratory rate (fR), arterial pressure, degree of sedation, gastrointestinal motility (GI), behavior changes and the mechanical nociceptive threshold (MNT) were evaluated. The MNT was determined with von Frey device method.Tr3 had a significant increase in their fR and more pronounced behavioral changes than other treatments.The Tr1 showed a significant increase in arterial pressure. The GI reduced significantly, mainly in Tr2. The tramadol did not change the MNT of the horses.The clinical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Analgesia; Horse; Opioid; Von Frey device.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000300021
Registros recuperados: 10
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