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Registros recuperados: 5
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Electrical field stimulation improves bone mineral density in ovariectomized rats BJMBR
Lirani-Galvão,A.P.R.; Bergamaschi,C.T.; Silva,O.L.; Lazaretti-Castro,M..
Osteoporosis and its consequent fractures are a great social and medical problem mainly occurring in post-menopausal women. Effective forms of prevention and treatment of osteoporosis associated with lower costs and the least side effects are needed. Electrical fields are able to stimulate osteogenesis in fractures, but little is known about their action on osteoporotic tissue. The aim of the present study was to determine by bone densitometry the effects of electrical stimulation on ovariectomized female Wistar rats. Thirty rats (220 ± 10 g) were divided into three groups: sham surgery (SHAM), bilateral ovariectomy (OVX) and bilateral ovariectomy + electrical stimulation (OVX + ES). The OVX + ES group was submitted to a 20-min session of a low-intensity...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Rats; Osteoporosis; Ovariectomy; Electrical stimulation; Bone mineral density; Osteogenesis.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100014
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Morphological Study of Bone Cranial in Athymic Mice International Journal of Morphology
Sesman,Ana; Ruvalcaba,Erika; Herrera,Arturo; Sánchez Guerrero,Sergio; Lecona,Hugo; Baena-Ocampo,Leticia; Solis,Lilia; Ávila,Hector; García de la Puente,Silvestre; Vargas,Betha; Guerrero,Xochitl; Velasquillo,Cristina.
The aim of our research was to create an osteogenic unit in the skulls of athymic mice; however, the first challenge we faced was to find sufficient and adequate data that would allow us to determine the morphological, immunohistochemical and microtopographical characteristics that could be used as normality standards in athymic mice skulls and, hence, a reference in the event of achieving the formation of de novo bone using the osteogenic unit we proposed. Knowing the normal bone morphology in the skull of athymic mice was a necessary precondition to develop subsequently an osteogenic unit possessing the Osteogenesis, Osteoinduction and Osteoconductivity that could be compared versus those in the normal bone during its formations and remodeling processes....
Tipo: Journal article Palavras-chave: Osteogenesis; Osteoinduction; Osteoconductivity.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100050
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Osteogenic molecules for clinical applications: improving the BMP-collagen system Biol. Res.
Arrabal,Pilar M; Visser,Rick; Santos-Ruiz,Leonor; Becerra,José; Cifuentes,Manuel.
Among the osteogenic growth factors used for bone tissue engineering, bone morphogenetic proteins (BMPs) are the most extensively studied for use in orthopaedic surgery. BMP-2 and BMP-7 have been widely investigated for developing therapeutic strategies and are the only two approved for use in several clinical applications. Due to the chemical and biological characteristics of these molecules, their authorised uses are always in combination with a carrier based on collagen type I. Although the use of these growth factors is considered safe in the short term, the very high doses needed to obtain significant osteoinduction make these treatments expensive and their long-term safety uncertain, since they are highly pleiotropic and have the capacity to induce...
Tipo: Journal article Palavras-chave: BMPs; Collagen; FGF-2; Growth factors; Osteogenesis; Recombinant proteins; RGD peptide.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000400013
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Proliferation and osteogenic activity of fibroblasts induced with fibronectin BJMBR
Zhang,W.-H.; Li,X.-L.; Guo,Y.; Zhang,Y..
The aim of this study was to determine the proliferation and osteogenic activity of fibroblasts induced with fibronectin and their possible dose-dependent relationship. The fibroblasts obtained by tissue explants adherent method were induced with fibronectin at different concentrations of 0, 10, 20, 40, 60, and 80 μg/mL for 14 days. The 3H-thymidine and 3H-proline incorporation test was used to evaluate the synthesis of DNA and collagen by fibroblasts, respectively. The mineralized nodules and osteocalcin secretion, as vital osteogenic indicators, were detected with tetracycline labeling and 125I-labeled competitive immunoassay, respectively. Fibronectin significantly increased the synthesis of DNA and collagen by fibroblasts, especially at the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fibroblast; Fibronectin; Proliferation; Osteogenesis.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000604
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The effects of 6-gingerol on proliferation, differentiation, and maturation of osteoblast-like MG-63 cells BJMBR
Fan,J.Z.; Yang,X.; Bi,Z.G..
We investigated whether 6-gingerol affects the maturation and proliferation of osteoblast-like MG63 cells in vitro. Osteoblast-like MG63 cells were treated with 6-gingerol under control conditions, and experimental inflammation was induced by tumor necrosis factor-α (TNF-α). Expression of different osteogenic markers and cytokines was analyzed by real-time PCR, Western blotting, and enzyme-linked immunosorbent assay. In addition, alkaline phosphatase (ALP) enzyme activity and biomineralization as markers for differentiation were measured. Treatment with 6-gingerol resulted in insignificant effects on the proliferation rate. 6-Gingerol induced the differentiation of osteoblast-like cells with increased transcription levels of osteogenic markers, upregulated...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 6-Gingerol; Interleukin-6; Nuclear factor-κB; Osteogenesis; Osteoblast.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700637
Registros recuperados: 5
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