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| Moreira,R.M.; Borges,P.P.; Lisboa,P.C.; Curty,F.H.; Moura,E.G.; Pazos-Moura,C.C.. |
| Steroid hormones have been implicated in the modulation of TSH secretion; however, there are few and controversial data regarding the effect of progesterone (Pg) on TSH secretion. Medroxyprogesterone acetate (MPA) is a synthetic alpha-hydroxyprogesterone analog that has been extensively employed in therapeutics for its Pg-like actions, but that also has some glucocorticoid and androgen activity. Both hormones have been shown to interfere with TSH secretion. The objective of the present study was to investigate the effects of MPA or Pg administration to ovariectomized (OVX) rats on in vivo and in vitro TSH release and pituitary TSH content. The treatment of adult OVX rats with MPA (0.25 mg/100 g body weight, sc, daily for 9 days) induced a significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Medroxyprogesterone acetate; Progesterone; Thyrotropin; Aging; Ovariectomy; Thyrotropin-releasing hormone. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900020 |
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| Lisbôa,P.C.; Curty,F.H.; Moreira,R.M.; Pazos-Moura,C.C.. |
| There is little information on the possible effects of estrogen on the activity of 5'-deiodinase (5'-ID), an enzyme responsible for the generation of T3, the biologically active thyroid hormone. In the present study, anterior pituitary sonicates or hepatic and thyroid microsomes from ovariectomized (OVX) rats treated or not with estradiol benzoate (EB, 0.7 or 14 µg/100 g body weight, sc, for 10 days) were assayed for type I 5'-ID (5'-ID-I) and type II 5'-ID (5'-ID-II, only in pituitary) activities. The 5'-ID activity was evaluated by the release of 125I from deiodinated 125I rT3, using specific assay conditions for type I or type II. Serum TSH and free T3 and free T4 were measured by radioimmunoassay. OVX alone induced a reduction in pituitary 5'-ID-I... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 5'-iodothyronine deiodinase; Ovariectomy; Estradiol; Triiodothyronine; Thyroxine; Thyrotropin. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200016 |
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| Claudio,E.R.G.; Almeida,S.A.; Mengal,V.; Brasil,G.A.; Santuzzi,C.H.; Tiradentes,R.V.; Gouvea,S.A.; Bissoli,N.S.; Santos,R.L.; Abreu,G.R.. |
| Estrogen deficiency and hypertension are considered major risk factors for the development of coronary heart disease. On the other hand, exercise training is considered an effective form to prevent and treat cardiovascular diseases. However, the effects of swimming training (SW) on coronary vascular reactivity in female ovariectomized hypertensive rats are not known. We aimed to evaluate the effects of SW on endothelium-dependent coronary vasodilation in ovariectomized hypertensive rats. Three-month old spontaneously hypertensive rats (SHR, n=50) were divided into four groups: sham (SH), sham plus swimming training (SSW), ovariectomized (OVX), and ovariectomized plus swimming training (OSW). The SW protocol (5 times/week, 60 min/day) was conducted for 8... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Swimming training; Ovariectomy; Coronary reactivity; Oxidative stress; Antioxidant enzymes. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100607 |
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| Turkozan,N. Y; Ulusoy,A. T; Balcioglu,H. A; Bal,F; Ozel,S. |
| The goal of the present study was to investigate the effects of ovariectomy and naproxen treatment on both femoral and mandibular bone mass and biomechanical competence. Sprague-Dawley rats were used and divided into five groups: baseline, sham ovariectomized, ovariectomized, sham ovariectomized + naproxen treatment, ovariectomized + naproxen treatment. Mandibles and femurs of the rats were extracted and bone mineral density of the extracted specimens were determined. The volumes and ash weights of the femurs and mandibles were estimated. Maximum loads of the femurs and mandibles were determined by using a three point bending test. Ovariectomy decreased bone mineral density of the femoral midshaft, however naproxen prevented this decrease. Neither... |
| Tipo: Journal article |
Palavras-chave: Ovariectomy; Naproxen; Bone mineral density; Maximum load. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300007 |
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