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| Registros recuperados: 12 | |
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| Nawab,A; Li,G; Liu,W; Lan,R; Wu,J; Zhao,Y; Kang,K; Kieser,B; Sun,C; Tang,S; Xiao,M; An,L. |
| ABSTRACT Heat stress induces oxidative stress, and reduces body antioxidant metabolite levels, which can affect poultry production performance. Dietary antioxidants protect birds against the adverse effects of heat stress. The effects of increasing concentrations of dietary curcumin on the antioxidant parameters of layers maintained under high-temperature conditions for nine weeks were evaluated. Roman laying hens (n = 336, 22 weeks old, 1420 g BW) were divided into three treatment groups. The first group served as a thermoneutral control (kept at 25 ± 1 °C). The second group was exposed to high temperatures (32 ± 1 °C, 6 h/d), given a basal diet. The third group was further divided into five treatment groups (100, 150, 200, 250, 300 mg/kg Curcumin) fed a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidant; Curcumin; Heat stress; Laying hen; Oxidative damage. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2019000200337 |
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| GIOVANELLA,FRANCIANNE; FERREIRA,GABRIELA K.; PRÁ,SAMIRA D.T. DE; CARVALHO-SILVA,MILENA; GOMES,LARA M.; SCAINI,GISELLI; GONÇALVES,RENATA C.; MICHELS,MONIQUE; GALANT,LETÍCIA S.; LONGARETTI,LUIZA M.; DAJORI,ANA LUIZA; ANDRADE,VANESSA M.; DAL-PIZZOL,FELIPE; STRECK,EMILIO L.; SOUZA,RENAN P. DE. |
| Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Primaquine; Chloroquine; Oxidative damage; DNA damage; Antimalarial drugs. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487 |
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| Frassetto,S.S.; Schetinger,M.R.C.; Webber,A.; Sarkis,J.J.F.; Netto,C.A.. |
| Brain ischemia followed by reperfusion causes neuronal death related to oxidative damage. Furthermore, it has been reported that subjects suffering from ischemic cerebrovascular disorders exhibit changes in circulating platelet aggregation, a characteristic that might be important for their clinical outcome. In the present investigation we studied tert-butyl hydroperoxide-initiated plasma chemiluminescence and thiol content as measures of peripheral oxidative damage in naive and preconditioned rats submitted to forebrain ischemia produced by the 4-vessel occlusion method. Rats were submitted to 2 or 10 min of global transient forebrain ischemia followed by 60 min or 1, 2, 5, 10 or 30 days of reperfusion. Preconditioned rats were submitted to a 10-min... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brain ischemia; Ischemic preconditioning; Oxidative damage; Hydroperoxide-initiated chemiluminescence; Plasma thiols. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000017 |
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| Batcioglu,K.; Gul,M.; Uyumlu,A.B.; Esrefoglu,M.. |
| The aim of this study was to evaluate the role of oxidative damage in pancreatitis-induced hepatic injury. Thirty-five rats were divided into five groups (each of 7 rats): control, cerulein (100 µg/kg body weight), cerulein and pentoxifylline (12 mg/kg body weight), cerulein plus L-NAME (10 mg/kg body weight) and cerulein plus L-arginine (160 mg/kg body weight). The degree of hepatic cell degeneration differed significantly between groups. Mean malondialdehyde levels were 7.00 ± 2.29, 20.89 ± 10.13, 11.52 ± 4.60, 18.69 ± 8.56, and 8.58 ± 3.68 nmol/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Mean catalase activity was 3.20 ± 0.83, 1.09 ± 0.35, 2.05 ± 0.91, 1.70 ± 0.60, and 2.85 ± 0.47 U/mg protein for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute pancreatitis; Liver injury; Oxidative damage; Pentoxifylline; L-NAME; L-arginine. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900001 |
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| Zembron-Lacny,A.; Dziubek,W.; Rynkiewicz,M.; Morawin,B.; Woźniewski,M.. |
| Regular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased oxidative stress. The purpose of this study was to identify the age-related changes in peripheral brain-derived neurotrophic factor (BDNF) and its relationship to oxidative damage and conventional cardiovascular disease (CVD) biomarkers, such as atherogenic index, C-reactive protein (hsCRP) and oxidized LDL (oxLDL), in active and inactive men. Seventeen elderly males (61-80 years) and 17 young males (20-24 years) participated in this study. According to the 6-min... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neurotrophins; Lipoproteins; Oxidative damage; Aging; Cardiorespiratory fitness. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000700603 |
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| Picco,Sebastián; Ponzzinibio,M. Virginia; Mattioli,Guillermo; Rosa,Diana; Minatel,Leonardo; Fazzio,Luis; Seoane,Analía. |
| Molybdenosis is a disease caused by the depressing effect of molybdenumn (Mo) on the physiological availability of Copper (Cu). The present study was carried out in order to analyze the ability of Mo to cause damage on the DNA integrity and changes in membrane fatty acids by oxidative damage. Holstein male calves were fed a Mo-supplemented diet for 9 months. Variables evaluated were plasma Cu concentration, erythrocyte Cu content and SOD activity, comet assay and analysis of the fatty acid composition of erythrocyte membranes. The statistical design was a completely randomized with one single factor and two replications. Copper plasma concentration, erythrocyte copper concentration and Cu/Zn SOD activity were analyzed using the t test. Chi-square test was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Molybdenum; Copper deficiency; Oxidative damage; DNA damage; Bos taurus; SOD activity. |
| Ano: 2012 |
URL: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-31952012000200002 |
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| Ávila,Renato Ivan de; Guerra,Meirielle Teixeira; Borges,Kamilla de Almeida Souza; Vieira,Marcelo de Sousa; Oliveira Júnior,Luiz Marcos de; Furtado,Humberto; Mota,Mariana Flavia da; Arruda,Andréa Fernandes; Valadares,Marize Campos. |
| This study investigated the chemoprotective effects of Punica granatum L. (Punicaceae) fruits alcoholic extract (PGE) on mice exposed to hexavalent chromium [Cr(VI)]. Animals were pretreated with PGE (25, 50 or 75 mg/kg/day) for 10 days and subsequently exposed to a sub-lethal dose of Cr(VI) (30 mg/kg). The frequency of micronucleated polychromatic erythrocytes in the bone marrow was investigated and the Cr(VI) levels were measured in the kidneys, liver and plasm. For the survival analysis, mice were previously treated with PGE for 10 days and exposed to a single lethal dose of Cr(VI) (50 mg/kg). Exposure to a sub-lethal dose of Cr(VI) induced a significant increase in the frequency of micronucleated cells. However, the prophylactic treatment with PGE led... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chemoprevention; Hexavalent chromium/induced genotoxicity; Oxidative damage; Pomegranate/chemoprotective effects; Punica granatum/chemoprotective effects; Punica granatum/pharmacognosy; Punicaceae/chemoprotective effects; Punicaceae/pharmacognosy. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400008 |
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| Registros recuperados: 12 | |
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