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Cytotoxicity of fumonisin B1 : implication of lipid peroxidation and inhibition of protein and DNA syntheses Inra
Abado-Becognée, K.; Mobio, T.A.; Ennamany, R.; Fleurat-Lessard, T.; Shier, W.T.; Badria, F.; Creppy, E.E..
The effects of fumonisin B1 (FB1) from Fusarium moniliforme on lipid peroxidation and protein and DNA syntheses were studied in monkey kidney cells (Vero cells). FB1 was found to be a potent inducer of malondialdehyde (MDA), one of the secondary products formed during lipid peroxidation. At 0.14 μM (0.1 μg/ml), FB1 induced 0.496 ± 0.1 nmoles of MDA/mg protein, compared to the control level 0.134 ± 0.01 nmoles of MDA/mg protein (P < 0.005). No inhibition of protein or DNA synthesis was observed at this concentration of FB1. Inhibition of protein and DNA syntheses was observed at FB1 concentrations >14 μM (10 μg/ml) with an IC50 of 33 μM for both protein synthesis and DNA synthesis. These results indicate that lipid peroxidation is a very sensitive...
Tipo: Journal Article Palavras-chave: FUSARIOSE; FUSARIUM MONILIFORME; FUMONISINE; PEROXYDATION DES LIPIDES; SYNTHESE PROTEIQUE.
Ano: 1998 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB9900011747074082&uri=/notices/prodinra1/2010/10/
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Effect of finishing mode (pasture- or mixed-diet) on lipid composition, colour stability and lipid oxidation in meat from Charolais cattle Inra
Gatellier, P.; Mercier, Y.; Juin, H.; Renerre, M..
Effects of pasture- or mixed-diet finishing mode on colour and lipid stability were measured in meat from Charolais steers, heifers and cows of different ages after refrigerated storage. Meats from pasture- and mixed-diet finished cattle have more or less significant differences in lipid composition which will influence the colour and lipid stability. The mixed-diet finished cattle have about the same proportions of saturated and monounsaturated lipids as pasture-diet finished animals; on the contrary, cattle fed on grass have higher proportions of n-3 PUFA, and to a less extent, of n-6. Finishing diet had an important effect on lipid stability, meat from pasture-finished animals showing significantly lower TBA-RS level than meat from mixed-diet finished...
Tipo: Journal Article Palavras-chave: VIANDE BOVINE; ALIMENTATION A L'HERBE; REGIME MIXTE; RACE BOVINE CHAROLAISE; TENEUR EN LIPIDES; PEROXYDATION DES LIPIDES; MYOGLOBINE; ACIDE GRAS POLYINSATURE PASTURE-DIET; MIXED-DIET; CATTLE; CHAROLAIS; VITAMIN E; LIPID CONTENT; LIPID OXIDATION; COLOUR; MYOGLOBIN; POLYUNSATURATED FATTY ACIDS.
Ano: 2005 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200687ca7e52&uri=/notices/prodinra1/2007/07/
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