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Effect of paclitaxel (Taxol®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in female Wistar rats BABT
Holanda,Cecília Maria de Carvalho Xavier; Oliveira,Elias Herculano de; Rocha,Louisianny Guerra da; Barbosa,Vanessa Santos de Arruda; Spyrides,Maria Helena Constantino; Aragão,Cícero Flávio Soares; Medeiros,Aldo da Cunha.
The evidence that natural or synthetic drugs can affect the biodistribution of radiopharmaceuticals (radiobiocomplexes) in setting of nuclear medicine clinic is already known. We studied the effect of Paclitaxel, an anti-neoplastic agent for the treatment of solid tumors, on the biodistribution of Na99mTcO4 in female rats. Paclitaxel (1mg/mL/week) was administered into animals in single dose during 3 weeks, with interval of 1 week among them. The control group received NaCl 0.9% solutions by the same via. One hour after the last dose, it was injected Na99mTcO4 in the animals. The percentage of activity per gram (%ATI/g) and biochemical and hematological determinations were performed. A significant increase were found in alanine aminotransferase, aspartate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paclitaxel; Drug interaction; Radiopharmaceuticals; Na99mTcO4; Antitumoral drug; Cancer.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700031
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Lipid core nanoparticles resembling low-density lipoprotein and regression of atherosclerotic lesions: effects of particle size BJMBR
Freitas,S.C.M.P.; Tavares,E.R.; Silva,B.M.O.; Meneghini,B.C.; Kalil-Filho,R.; Maranhão,R.C..
Particles are usually polydispersed and size is an important feature for lipid-based drug delivery systems in order to optimize cell-particle interactions as to pharmacologic action and toxicity. Lipid nanoparticles (LDE) with composition similar to that of low-density lipoprotein carrying paclitaxel were shown to markedly reduce atherosclerosis lesions induced in rabbits by cholesterol feeding. The aim of this study was to test whether two LDE fractions, one with small (20–60 nm) and the other with large (60–100 nm) particles, had different actions on the atherosclerotic lesions. The two LDE-paclitaxel fractions, prepared by microfluidization, were separated by density gradient ultracentrifugation and injected (4 mg/body weight, intravenously once a week)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Solid lipid nanoparticles; Drug targeting; Paclitaxel; Atherosclerosis; Particle size.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300612
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Screening of endophytic fungi stored in a culture collection for taxol production BJM
Andrade,Hortência Farias de; Araújo,Lívia Caroline Alexandre de; Santos,Bruno Souza dos; Paiva,Patrícia Maria Guedes; Napoleão,Thiago Henrique; Correia,Maria Tereza dos Santos; Oliveira,Maria Betânia Melo de; Lima,Gláucia Manoella de Souza; Ximenes,Rafael Matos; Silva,Túlio Diego da; Silva,Girliane Regina da; Silva,Márcia Vanusa da.
Abstract In this work, four isolates of endophytic fungi (Alternaria alternata, Colletotrichum gloesporioides, Glomerella cingulata and Nigrospora sphaerica), deposited in the culture collection ‘University Recife Mycologia’ (URM) at the Universidade Federal de Pernambuco, were characterized for the genes ITS 1 and 4 (region 5.8 S) and evaluated for taxol production.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Paclitaxel; Taxol route genes; ITS; Colletotrichum gloesporioides.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000500059
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Synergistic effect of microRNA and albumin-bound nanoparticles for inhibition of glioblastoma cancer cell proliferation BJPS
Shariatnasery,Maria; Irani,Shiva; Soleimani,Masoud; Goodarzi,Navid; Dinarvand,Rassoul.
The functional significance of upregulation miR-34a in combination with albumin-bound paclitaxel nanoparticles in U251 glioblastoma cell line has been evaluated. The MTT assay determined that miR-34a and albumin-bound paclitaxel nanoparticles can reduce cell viability, but the combination of both factors has a stronger effect on cell viability. The application of qRT-PCR has demonstrated that the transduction of miR-34a could lead to exogenous upregulation of miR-34a level and downregulation of SURVIVIN. Moreover, treatment of U251 cells with miR-34a and nanoparticles together considerably inhibit SURVIVIN expression compared to miR-34a and nanoparticles alone. Flow cytometry showed that upon miR-34a overexpression cell cycle arrested in G1 phase, while...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MiR-34a; Glioblastoma; Albumin; Paclitaxel; Nanoparticles; Combination therapy.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100535
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