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Palavra-chave Paracoccidioides brasiliensis (17) Paracoccidioidomycosis (9) Apoptosis (1) Armadillos (1) BALB/c mice (1) Bioactive peptides (1) Biochemical profile (1) Canova (1) Cell-free antigens (1) Cerebrospinal fluid (1) Decorin (1) Delayed-type hypersensitivity reaction (1) Dendritic cells (1) Diagnóstico micológico (1) Dot-ELISA (1) Epidemiology (1) Fungal virulence (1) Gp43 (1) Granulomatous lesions (1) Immunodiagnostic tool (1) Mais... Tipo do documento Info:eu-repo/semantics/article (16) Info:eu-repo/semantics/report (1) Ano 2017 (1) 2015 (1) 2014 (1) 2013 (1) 2012 (1) 2011 (1) 2010 (1) 2009 (1) 2008 (1) 2007 (1) 2006 (2) 2005 (1) 2004 (1) 2003 (2) 2001 (1) Mais... País Brazil (16) Argentina (1) Idioma Inglês (16) Espanhol (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 17 Primeira ... 1 ... Última An unusual case of paracoccidioidomycosis in Brazil BJM Macêdo,Danielle Patrícia Cerqueira; Neves,Rejane Pereira; Magalhães,Oliane Maria Correia; Lacerda Filho,Armando Marsden. This paper reports an unusual case of paracoccidioidomycosis with ulcerations in the head and nose in a Brazilian man. For diagnosis, direct microscopic examination of ulcer secretion and skin samples treated with potassium hydroxide was performed. The isolation of Paracoccidioides brasiliensis occurred at 28ºC and 37ºC on Sabouraud agar with chloranphenicol. Diagnosis was established by the presence of isolated and multiple budding yeast-like cells and typical fungus growth of P. brasiliensis. Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioidomycosis; Paracoccidioides brasiliensis; Unusual head lesion. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000100017 Antifungal and antitumor models of bioactive protective peptides Anais da ABC (AABC) Rodrigues,Elaine G.; Dobroff,Andrey S.; Taborda,Carlos P.; Travassos,Luiz R.. Peptides are remarkably reactive molecules produced by a great variety of species and able to display a number of functions in uni-and multicellular organisms as mediators, agonists and regulating substances. Some of them exert cytotoxic effects on cells other than those that produced them, and may have a role in controlling subpopulations and protecting certain species or cell types. Presently, we focus on antifungal and antitumor peptides and discuss a few models in which specific sequences and structures exerted direct inhibitory effects or stimulated a protective immune response. The killer peptide, deduced from an antiidiotypic antibody, with several antimicrobial activities and other Ig-derived peptides with cytotoxic activities including antitumor... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bioactive peptides; Paracoccidioides brasiliensis; Tumor cells; Killer peptide; Melanoma; Apoptosis. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300015 Biochemical responses in mice experimentally infected with Paracoccidioides brasiliensis and treated with Canova BABT Takahachi,Gisele; Maluf,Márcia Luzia Ferrarezi; Svidzinski,Terezinha Inez Estivalet; Akimoto-Günther,Luciene Setsuko; Hübler,Márcia Rosangela Neves de Oliveira; Bersani-Amado,Ciomar Aparecida; Cuman,Roberto Kenji Nakamura. The objective of this work was to evaluate biochemical parameters in Paracoccidioides brasiliensis infected mice and the effect of Canova medicine on these parameters. Mice infected with the isolate Paracoccidioides brasiliensis Pb18 and treated with Canova for 17 weeks were used. The biochemical parameters analysed were the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and amylase, and the concentration of total proteins, albumin and globulins. The results suggested that the animals that were treated with Canova had less functional alterations in their internal organs. Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioidomycosis; Biochemical profile; Canova; Paracoccidioides brasiliensis. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000700006 Cell-free antigens from precocious Paracoccidioides brasiliensis culture induce a typical delayed-type hypersensitivity reaction J. Venom. Anim. Toxins incl. Trop. Dis. CJ,Fecchio; LA,Dias-Melicio; AMVC,Soares; S,Guimarães; MTS,Peraçoli; A,Sartori. Cell-free antigens (CFAg) derived from Paracoccidioides brasiliensis have typically been used in immunodiffusion reactions for serodiagnosis or therapeutic follow-up of paracoccidioidomycosis patients. Thus, we investigated the usefulness of CFAg obtained from cultures at different ages, to evaluate cellular immunity by the footpad test, in experimental murine paracoccidioidomycosis. Male mice infected with P. brasiliensis 265 strain were challenged in the footpad with CFAg obtained from four- (4d CFAg) or 11-day-old cultures (11d CFAg). The increase in footpad swelling provoked by 4d CFAg and 11d CFAg was similar and showed significant difference in relation to control groups. However, the infiltrate pattern was strikingly different: 4d CFAg induced a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioides brasiliensis; Cell-free antigens; Delayed-type hypersensitivity reaction; Gp43; Murine paracoccidioidomycosis. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300012 Central Nervous System Paracoccidioidomycosis: an overview BJID Almeida,Sérgio Monteiro de. Paracoccidioidomycosis (PCM) is an infectious disease, endemic to subtropical areas of Central and South America, caused by the dimorphic fungus Paracoccidioides brasiliensis. It is a chronic disease, mostly affecting adult males, with a mean patient age of 44 years. Central nervous system involvement (CNS PCM) has been found in 13% of the patients with systemic disease. We reviewed the clinical presentation, diagnosis techniques and treatments for CNS PCM. Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioidomycosis; Neuroparacoccidioidomycosis; Cerebrospinal fluid; Paracoccidioides brasiliensis. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200002 Experimental infections with Paracoccidioides brasiliensis obtained from armadillos: comparison to clinical isolates BJID Nishikaku,Angela Satie; Peraçoli,Maria Terezinha S.; Bagagli,Eduardo; Sugizaki,Maria Fátima; Sartori,Alexandrina. Paracoccidioides brasiliensis causes paracoccidioidomycosis (PCM) that is one of the most prevalent systemic human mycoses in Latin America. Armadillos show a high incidence of PCM infection and could, therefore, be a natural reservoir for this fungus. In this study were compared the virulence profiles of isolates obtained from nine-banded armadillos (Dasypus novemcinctus) (PbT1 and PbT4) and isolates from PCM patients (Pb265 and Bt83). Pathogenicity was evaluated by fungal load and analysis of colony morphology. Immunity against the fungus was tested by delayed type hypersensitivity test (DTH) and antibody quantification by ELISA. The higher virulence of PbT1 and PbT4 was suggested by higher fungal load in spleen and lungs. Armadillo isolates and Bt83... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioides brasiliensis; Armadillos; Infection; BALB/c mice. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100013 Immunohistochemical demonstration of TGF-ß and decorin in paracoccidioidal granulomas BJMBR Nishikaku,A.S.; Burger,E.. Different patterns of granulomas have been observed in 6- to 8-week-old mice after ip inoculation with 5 x 10(6) yeast cells of Paracoccidioides brasiliensis. Transforming growth factor-ß (TGF-ß) is a cytokine that has been shown to participate in fibrosis and granuloma formation; its activities seem to be modulated by the small proteoglycan decorin. In the present study, TGF-ß and decorin expression in epiploon granulomas was assessed by immunohistochemistry in susceptible (B10.A) and resistant (A/J) mice after 15, 30, 120 and 150 days of P. brasiliensis ip infection. The epiploon was collected, fixed in Methacarn solution and embedded in paraffin, and 5-µm thick sections were used for immunohistochemical analysis employing the... Tipo: Info:eu-repo/semantics/article Palavras-chave: TGF-ß; Decorin; Paracoccidioides brasiliensis; Granulomatous lesions; Susceptibility and resistance. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800014 Juvenile paracoccidioidomycosis in urban area: report of two cases BJID Carneiro,Rodrigo da Costa; Miranda,Bianca Grassi de; Camilo Neto,Carlos; Tsukumo,Marina K; Fonseca,Cibele LC; Mendonça,João Silva de. We present two cases of juvenile form of paracoccidioidomycosis (PCM), a systemic mycosis frequently found in rural areas, whose prognosis is poor in children and young adults. They are a 14-year-old boy and a 25-year-old woman, both residents in an urban area in São Paulo - Brazil, without any history of travelling to an endemic area. They have been admitted to the hospital due to fever, weight loss and lymphadenopathy. The diagnosis was confirmed by serologic and histopathologic study. Patients have recovered after therapy with oral itraconazole and were discharged from hospital, maintaining outpatient visits. In this article, the authors discuss the unusual presentation of PCM in an urban area. Tipo: Info:eu-repo/semantics/report Palavras-chave: Juvenile paracoccidioidomycosis; Lymphadenopathy; Paracoccidioides brasiliensis; Urban area. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100015 Natural antibodies in paracoccidioidomycosis BJM Unterkircher,Carmelinda S.; Leão,Mariella V.P.; Blotta,Maria Heloisa S.L.; Camargo,Zoilo Pires de. Recent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied. This work was undertaken to investigate the presence of natural antibodies in paracoccidioidomycosis (PCM). In addition, we analyzed anti-P. brasiliensis antibodies and their distribution in IgG subclasses in order to acquire better knowledge about the humoral immune response in this mycosis. Our findings show that the natural antibody response is not very much increased in PCM when compared with other parasite infections and this response is restricted to a few specificities, suggesting that P. brasiliensis moderately triggers CD5+ B... Tipo: Info:eu-repo/semantics/article Palavras-chave: Natural antibodies; Paracoccidioides brasiliensis; Paracoccidioidomycosis. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100009 Paracoccidioides brasiliensis en material fecal ABCL Bava,Amadeo Javier; Álvarez Guidi,Gabriela. Se comunica la presencia de Paracoccidioides brasiliensis en una muestra de materia fecal de un paciente que padecía la forma juvenil de paracoccidioidomicosis, la que fue enviada al laboratorio para su estudio parasitológico. Preparaciones microscópicas de los concentrados de la muestra revelaron, tanto en preparaciones en fresco como previa coloración con PAS, la presencia de elementos fúngicos redondeados, de pared gruesa y tamaño variable, entre 7 y 50 µ, carentes o con escasos brotes y en algunos casos, agrupados en cadenas o racimos. P. brasiliensis fue además observado en una muestra de esputo del mismo paciente y su presencia en las heces podría deberse a la deglución de las secreciones pulmonares cargadas de levaduras y su posterior pasaje a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioidomicosis; Paracoccidioides brasiliensis; Diagnóstico micológico. Ano: 2006 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572006000300012 Paracoccidioidomycosis in southern Rio Grande do Sul: a retrospective study of histopathologically diagnosed cases BJM Souza,Silvana Pereira de; Jorge,Valéria Magalhães; Orzechowski Xavier,Melissa. Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the fungus Paracoccidioides brasiliensis and is endemic to Brazil. The aim of this study was to perform a retrospective analysis of the PCM cases in the countryside south of Rio Grande do Sul, Brazil. The files from four histopathology laboratories located in the city of Pelotas were obtained, and all of the epidemiological and clinical data from the PCM diagnosed cases were collected for analysis. A total of 123 PCM cases diagnosed between 1966 and 2009 were selected. Of these patients, 104 (84.5%) were male, and 17 were female. The patients ranged from 02 to 92 years of age. Fifty-two cases (41.9%) were obtained from the oral pathology laboratory, and the remaining 71 cases (58.1%) were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioides brasiliensis; Epidemiology; Systemic mycosis. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000100035 Retrospective seroepidemiological analysis of patients with suspicion of paracoccidioidomycosis in São Paulo State, Brazil J. Venom. Anim. Toxins incl. Trop. Dis. Kamikawa,CM; Kohara,VS; Passos,AN; Vicentini,AP. The geographic distribution of paracoccidioidomycosis (PCM) in the Brazilian state of São Paulo was evaluated in a retrospective study using secondary data from serological analyses, carried out by double immunodiffusion assay of patients with PCM suspicion, from January 1999 to May 2010. Sixty percent of 10,176 patients, from 239 cities, were serologically reactive to P. brasiliensis. The cities that showed the most serological reactivity among patients were São João da Boa Vista (85%), Piracicaba (75%), Sorocaba (73%), Campinas (72%) and São Paulo (62%). São Paulo state has an area of 248,209.4 km²; the climate is tropical and sub-tropical with annual temperatures between 18 and 24ºC, high rainfall (900 to 1800 mm/year), rainy summers and mild winters.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioides brasiliensis; Paracoccidioidomycosis; Immunological tests; Seroepidemiological studies. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000300003 Standardization and validation of Dot-ELISA assay for Paracoccidioides brasiliensis antibody detection J. Venom. Anim. Toxins incl. Trop. Dis. Kamikawa,Camila Mika; Mendes,Rinaldo Poncio; Vicentini,Adriana Pardini. Abstract Background Paracoccidioidomycosis (PCM) is a neglected systemic mycosis caused by a dimorphic fungus of the Paracoccidioides genus. The standard diagnosis is based on isolation of the fungi in culture, and by microscopic visualization of characteristic multiple budding yeast cells in biological samples. However, in some situations, access to the site of injury prevents the collection of biological material. A variety of immuno-serological techniques has proven useful for allowing inferring diagnosis with a certain degree of certainty, thus optimizing time. The aim of this study was to standardize and validate the Dot-ELISA (DE) assay, comparing it with the serological standard, double immunodiffusion (DI). Methods In order to standardize the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioidomycosis; Paracoccidioides brasiliensis; Immunodiagnostic tool; Dot-ELISA; Validation. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100305 The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice BJMBR Tristão,F.S.M.; Rocha,F.A.; Dias,F.C.; Rossi,M.A.; Silva,J.S.. Paracoccidioidomycosis (PCM) is a chronic systemic mycosis caused by the inhalation of the thermally dimorphic fungus Paracoccidioides brasiliensis as well as the recently described P. lutzii. Because the primary infection occurs in the lungs, we investigated the differential involvement of the right and left lungs in experimental P. brasiliensis infection. Lungs were collected from C57BL/6 mice at 70 days after intravenous infection with 1×106 yeast cells of a virulent strain of P. brasiliensis (Pb18). The left lung, which in mice is smaller and has fewer lobes than the right lung, yielded increased fungal recovery associated with a predominant interleukin-4 response and diminished synthesis of interferon-γ and nitric oxide compared with the right lung.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lung; Paracoccidioidomycosis; Paracoccidioides brasiliensis. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000839 The low efficiency of dendritic cells and macrophages from mice susceptible to Paracoccidioides brasiliensis in inducing a Th1 response BJMBR Almeida,S.R.; Lopes,J.D.. In the present study we evaluated T cell proliferation and Th lymphokine patterns in response to gp43 from Paracoccidioides brasiliensis presented by isolated dendritic cells from susceptible and resistant mice. T cell proliferation assays showed that dendritic cells from susceptible mice were less efficient than those from resistant mice. The pattern of T cell lymphokines stimulated by dendritic cells was always Th1, although the levels of IL-2 and IFN-gamma were lower in T cell cultures from susceptible mice. To determie whether different antigen-presenting cells such as macrophages and dendritic cells stimulated different concentrations of Th1 lymphokines, the production of IFN-gamma and IL-2 was measured. It was observed that dendritic cells were more... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dendritic cells; Paracoccidioidomycosis; Paracoccidioides brasiliensis; Th1/Th2. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400014 Thymic atrophy and fungal virulence during experimental paracoccidioidomycosis BJM Brito,Vânia Nieto; Souto,Paula Cristina de Souza; Gameiro,Jacy; Cruz-Höfling,Maria Alice; Verinaud,Liana. The immunosuppression observed in systemic mycosis can be related to primary lymphoid organs damage. Thus, our laboratory has studied the effects of the Paracoccidioides brasiliensis infection on the thymus of mice. Here, thymuses of susceptible and resistant mice were evaluated after inoculation with highly and slightly virulent isolates of the fungus. All groups presented thymic atrophy, loss of corticomedullary delimitation and increase of apoptotic index. However, mice inoculated with high virulent strain showed earlier and stronger alterations suggesting that thymic atrophy can be directly related to the fungal virulence and to the immunosuppression. Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioides brasiliensis; Thymus; Fungal virulence. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000500005 Validation and clinical application of a nested PCR for paracoccidioidomycosis diagnosis in clinical samples from Colombian patients BJID Gaviria,Marcela; Rivera,Vanessa; Muñoz-Cadavid,Cesar; Cano,Luz Elena; Naranjo,Tonny Williams. Paracoccidioidomycosis is a systemic and endemic mycosis, restricted to tropical and subtropical areas of Latin America. The infection is caused by the thermal dimorphic fungus Paracoccidioides brasiliensisand Paracoccidioides lutzii. The diagnosis of paracoccidioidomycosis is usually performed by microscopic examination, culture and immunodiagnostic tests to respiratory specimens, body fluids and/or biopsies; however these methods require laboratory personnel with experience and several days to produce a result. In the present study, we have validated and evaluated a nested PCR assay targeting the gene encoding the Paracoccidioides gp43membrane protein in 191 clinical samples: 115 samples from patients with proven infections other than... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioides brasiliensis; Nested PCR; Paracoccidioidomycosis; Molecular diagnosis. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400376 Registros recuperados: 17 Primeira ... 1 ... Última

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