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Optimization of a spectrofluorimetric method based on a central composite design for the determination of potassium losartan in pharmaceutical products BJPS
Demirkaya-Miloglu,Fatma; Yaman,Mehmet Emrah; Kadioglu,Yucel.
Here, a spectrofluorimetric method for the determination of potassium losartan (PL) in pharmaceutical products is described. The effects of critical parameters, pH, acid molarity, and temperature, on the fluorescence intensity of PL were analyzed, and these parameters were optimized using a central composite design (CCD). The highest fluorescent intensity at excitation (λex) and emission (λem) wavelengths of 248 nm and 410 nm, respectively, was achieved using 0.01 M sulfurous acid (pH 2) at 21.6 °C. Under optimum conditions, the method was linear from 0.025-0.5 µg/mL, with a reasonably high correlation coefficient (0.9993). Furthermore, the method was very sensitive (LOQ, 0.006), accurate (RE, ≤7.06), and precise (%RSD, ≤6.51). After development and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Potassium losartan/central composite design; Spectrofluorimetry/quantitative analysis; Pharmaceutical formulations/quantitative analyis.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300611
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Simultaneous estimation of rosuvastatin and amlodipine in pharmaceutical formulations using stability indicating HPLC method BJPS
Ashfaq,Muhammad; Akhtar,Tazeem; Mustafa,Ghulam; Danish,Muhammad; Razzaq,Syed Naeem; Nazar,Muhammad Faizan.
A viable cost-effective and isocratic approach employing C-18 column (250 mm × 4.6 mm, 5 µm) based HPLC has been utilized to separate and estimate the drugs, rosuvastatin, amlodipine and their stress induced degradation products, simultaneously in pharmaceutical formulations. Focused on ICH guideline parameters, the efficient separation of both drugs and their degradation products was achieved by optimizing a 30:70 (v/v) solvent mixture of acetonitrile and 0.1 M ammonium acetate buffer (pH 5) as mobile phase. The flow rate of the mobile phase was 1.5 mL/min and all the detections were carried out at 240 nm using UV detector. The method was linear in the concentration range of 1-200 µg/mL for rosuvastatin with 0.996 coefficient of determination value. For...
Tipo: Info:eu-repo/semantics/article Palavras-chave: High Performance Liquid Chromatography/quantitative analysis; Rosuvastatin/quantitative determination; Amlodipine/quantitative determination; Pharmaceutical formulations/quantitative analyis; Acetonitrile; UV Detector.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300629
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