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Registros recuperados: 8
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Angiotensin II type 1 receptor A1166C GENE polymorphism and essential hypertension in San Luis Biocell
Lapierre,Alicia Viviana; Arce,María Elena; Lopez,José Raúl; Ciuffo,Gladys María.
Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. The angiotensin II type 1 receptor mediates the vasoconstrictor and growthpromoting effects of Ang II. The A1166C polymorphism of the AT1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. We investigated the association between this A1166C polymorphism and hypertension in hypertense and normotense subjects from San Luis (Argentina) by mismatch PCR-RFLP analysis. Hypertense patients exhibited significant increases in lipid related values and body mass index. The frequency of occurrence of the C1166 allele was higher among...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; A1166C polymorphism; Risk factors; RAS system; Pharmacogenetics.
Ano: 2006 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000300005
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Future perspective for diagnosis in autoimmune diseases Anais da ABC (AABC)
Andrade,Luis E. C..
Human beings have taken successive approaches for the understanding and management of diseases. Initially brewed in supernatural concepts and mystical procedures, a vigorous scientific approach has emerged on the grounds of fundamental disciplines such as anatomy, microbiology, biochemistry, physiology, immunology, pathology, and pharmacology. The resulting integrated knowledge contributed to the current classification of diseases and the way Medicine is carried out today. Despite considerable progress, this approach is rather insufficient when it comes to systemic inflammatory conditions, such as systemic lupus erythematosus, that covers clinical conditions ranging from mild pauci-symptomatic diseases to rapidly fatal conditions. The treatment for such...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Autoimmunity; Pharmacogenetics; Gene polymorphism; Auto-inflammatory diseases; Systemic lupus erythematosus; Rheumatoid arthritis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300004
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High baseline serum total and LDL cholesterol levels are associated with MDR1 haplotypes in Brazilian hypercholesterolemic individuals of European descent BJMBR
Rodrigues,A.C.; Rebecchi,I.M.M.; Bertolami,M.C.; Faludi,A.A.; Hirata,M.H.; Hirata,R.D.C..
The MDR1 gene encodes the P-glycoprotein, an efflux transporter with broad substrate specificity. P-glycoprotein has raised great interest in pharmacogenetics because it transports a variety of structurally divergent drugs, including lipid-lowering drugs. The synonymous single-nucleotide polymorphism C3435T and the nonsynonymous single-nucleotide polymorphism G2677T/A in MDR1 have been indicated as potential determinants of variability in drug disposition and efficacy. In order to evaluate the effect of G2677T/A and C3435T MDR1 polymorphisms on serum levels of lipids before and after atorvastatin administration, 69 unrelated hypercholesterolemic individuals from São Paulo city, Brazil, were selected and treated with 10 mg atorvastatin orally once daily for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MDR1 gene; Hypercholesterolemia; Statins; Single nucleotide polymorphism; Pharmacogenetics.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900014
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High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations BJMBR
Teixeira,D.; Vargens,D.; Príncipe,A.; Oliveira,E.; Amorim,A.; Prata,M.J.; Suarez-Kurtz,G..
A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the São Tomé e Príncipe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups....
Tipo: Info:eu-repo/semantics/article Palavras-chave: African populations; GSTM3 polymorphisms; Multidimensional scaling analysis; Pharmacogenetics; Population diversity.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700010
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HLA-B*5701 frequency in Chilean HIV-infected patients and in general population BJID
Poggi,Helena; Vera,Alejandra; Lagos,Marcela; Solari,Sandra; Rodríguez P,Luis; Pérez,Carlos M.
It has been demonstrated that HLA-B*5701 screening reduces the risk for hypersensitivity reaction to abacavir in HIV-infected patients. Since B*5701 prevalence varies among different populations, it is important to determine the carrier frequency prior to its use for the screening of HIV-infected patients.The aim of this study was to determine HLA-B*5701 carrier frequency in Chilean general population and HIV-infected patients referred for B*5701 typing. For that purpose 300 blood bank donors and 492 abacavir-naïve HIV-infected patients from Chile were screened for B*5701 by a sequence specific primer PCR.We detected 14/300 (4.7%) B*57-positive individuals in the Chilean general population, 11 (3.7%) were B*5701 positive, and 3 (1%) had another subtype.All...
Tipo: Info:eu-repo/semantics/other Palavras-chave: HLA-B*5701; HIV; Abacavir; Chile; Pharmacogenetics.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500015
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Pharmacogenetic implications in the management of metabolic diseases in Brazilian populations BJPS
Hirata,Rosario Dominguez Crespo; Cerda,Alvaro; Genvigir,Fabiana Dalla Vecchia; Hirata,Mario Hiroyuki.
Dyslipidemia, diabetes, obesity and hypertension are common metabolic diseases. In the last decades, unhealthy lifestyle and aging have leads to an increased incidence of these diseases, increasing morbidity and mortality by cardiovascular causes. The treatment of metabolic diseases includes life-style interventions as healthy diet and physical exercise, as well as pharmacological interventions. Several drugs are available for the management of metabolic diseases including among others lipid-lowering antidiabetics and antihypertensive drugs. Variability in response to these drugs is influenced by both genetic and non-genetic factors. Polymorphisms in genes related to drug pharmacokinetics and pharmacodynamics have been shown to influence drug efficacy and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pharmacogenetics; Metabolic diseases; Gene polymorphism; Drug response.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700404
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Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups Genet. Mol. Biol.
Hiragi,Cássia de Oliveira; Miranda-Vilela,Ana Luisa; Rocha,Dulce Maria Sucena; ,Silviene Fabiana de; Hatagima,Ana; Klautau-Guimarães,Maria de Nazaré.
Antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX1) reduce the oxidation rates in the organism. Gluthatione S-transferases (GSTs) play a vital role in phase 2 of biotransformation of many substances. Variation in the expression of these enzymes suggests individual differences for the degree of antioxidant protection and geographical differences in the distribution of these variants. We described the distribution frequency of CAT (21A/T), SOD2 (Ala9Val), GPX1 (Pro198Leu), GSTM1 and GSTT1 polymorphisms in three Brazilian population groups: Kayabi Amerindians (n = 60), Kalunga Afro-descendants (n = 72), and an urban mixed population from Federal District (n = 162). Frequencies of the variants observed in Kalunga...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioxidants; PCR-RFLP; Gene polymorphisms; Brazilian ethnicities; Population genetics; Pharmacogenetics.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100003
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The Brazilian contribution to Attention-Deficit/Hyperactivity Disorder molecular genetics in children and adolescents Genet. Mol. Biol.
Genro,Júlia Pasqualini; Roman,Tatiana; Rohde,Luis Augusto; Hutz,Mara Helena.
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common psychiatric condition of children worldwide. This disorder is defined by a combination of symptoms of inattention and hyperactivity/impulsivity. Diagnosis is based on a sufficient number of symptoms causing impairment in these two domains determining several problems in personal and academic life. Although genetic and environmental factors are important in ADHD etiology, how these factors influence the brain and consequently behavior is still under debate. It seems to be consensus that a fronto-subcortical dysfunction is responsible, at least in part, for the ADHD phenotype spectrum. The main results from association and pharmacogenetic studies performed in Brazil are discussed. The investigations...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ADHD; Candidate genes; Pharmacogenetics.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000600007
Registros recuperados: 8
Primeira ... 1 ... Última
 

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