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	Provedor de dados 60 (2) Autor Al-Hariri,Sahar (1) Sankari,Thaeer (1) Savardekar,Ravi Yashwant (1) Sherikar,Amol Shantinath (1) Palavra-chave Poloxamer 188 (2) Accelerated stability (1) Cefuroxime axetil/dissolution (1) Eudragit S 100 (1) Ketoprofen (1) Solid Dispersion (1) Solid dispersion (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Preparation and characterization of cefuroxime axetil solid dispersions using poloxamer 188 60 Sankari,Thaeer; Al-Hariri,Sahar. The main objective of the present work was to enhance the solubility and dissolution rate of poorly water-soluble drug cefuroxime axetil (CA) by formulating it into solid dispersions (SDs) with water soluble carrier poloxamer 188. Different methods were employed to prepare the dispersion, such as: Solvent method (SM), Kneading method (KM), Melt evaporation method (MEM) and Physical mixture (PM) in different drug: carrier ratios 1:1, 1:2 and 1:3 (cefuroxime axetil: poloxamer 188). The physical mixture(s) and solid dispersion(s) were characterized for drug carrier interaction, drug content, solubility, dissolution rate, differential scanning calorimetry (DSC) and FT-IR study. The dissolution rate of the prepared solid dispersion systems was determined in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cefuroxime axetil/dissolution; Poloxamer 188; Solid dispersion. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400622 Screening of Ketoprofen-Poloxamer and Ketoprofen-Eudragit solid dispersions for improved physicochemical characteristics and dissolution profile 60 Savardekar,Ravi Yashwant; Sherikar,Amol Shantinath. The aim of the present study was to enhance the dissolution rate of an NSAID drug Ketoprofen by formulating it into solid dispersions with water soluble carrier Poloxamer 188 and Eudragit S 100. The solid dispersions of Ketoprofen with Poloxamer 188 were prepared at 1:1, 1:1.5 and 1:2 (Ketoprofen: Poloxamer 188) ratio by Solvent evaporation methods. The same concentration ratio was used for the preparation of solid dispersion with Eudragit S 100 by melting/fusion technique. Further, solid dispersions were investigated by solubility, ATR-FTIR, XRD, DSC, surface morphology, in-vitro dissolution and accelerated stability study. Results demonstrated that both Poloxamer 188 and Eudragit S 100 improve solubility of drugs by 8–10 folds. The result of ATR-FTIR... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ketoprofen; Solid Dispersion; Poloxamer 188; Eudragit S 100; Accelerated stability. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100579 Registros recuperados: 2 Primeira ... 1 ... Última

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