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Formulation and characterization of gastroretentive discs containing famotidine 52
Raval,Jignyasha Amitkumar; Patel,Madhabhai M.
In this work a different type of formulation, as disc, containing a selected mucoadhesive polymer, fillers, and binders were investigated for their potential as a mucoadhesive gastroretentive delivery system to deliver famotidine in the stomach. Various types of hydrophilic diluents were evaluated for their swelling and mucoadhesive property and one (polyvinylpyrrolidone, PVP) was selected to combine with the selected mucoadhesive polymer (polyethylene oxide, PEO). Discs with different ratios of PEO and PVP were prepared and evaluated for swelling, dissolution, and mucoadhesion. The swelling property of the discs increased as the concentration of PEO was increased and also did the mucoadhesion. These discs retained their integrity and adherence onto...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesion; Discs; Gastroretentive; Polyethylene oxide; Polyvinylpyrrolidone.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200010
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Formulation of gastroretentive floating drug delivery system using hydrophilic polymers and its in vitro characterization 60
Meka,Venkata Srikanth; Dharmanlingam,Senthil Rajan; Kolapalli,Venkata Ramana Murthy.
The aim of the present research is to formulate and evaluate the gastroretentive floating drug delivery system of antihypertensive drug, propranolol HCl. Gastroretentive floating tablets (GRFT) were prepared by using a synthetic hydrophilic polymer polyethylene oxide of different grades such as PEO WSR N-12 K and PEO 18 NF as release retarding polymers and calcium carbonate as gas generating agent. The GRFT were compressed by direct compression strategy and the tablets were evaluated for physico-chemical properties, in vitro buoyancy, swelling studies, in vitro dissolution studies and release mechanism studies. From the dissolution and buoyancy studies, F 9 was selected as an optimized formulation. The optimized formulation followed zero order rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gastroretentive floating/ drug delivery system; Gastroretentive floating tablets/in vitro dissolution; Hydrophilic polymers/use in drug delivery system; Polyethylene oxide; Propranolol HCl/delivery system.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200431
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