SABIIA - Sistema Aberto e Integrado de Informação em Agricultura (Sabiia)

Almeida,A.P.; Frábregas,B.C.; Madureira,M.M.; Santos,R.J.S.; Campagnole-Santos,M.J.; Santos,R.A.S..

It has been shown that angiotensin-(1-7) (Ang-(1-7)) infusion potentiates the bradykinin (BK)-induced hypotensive response in conscious rats. The present study was conducted to identify Ang-(1-7)-BK interactions in the isolated rat heart perfused according to the Langendorff technique. Hearts were excised and perfused through the aortic stump under a constant flow with Krebs-Ringer solution and the changes in perfusion pressure and heart contractile force were recorded. Bolus injections of BK (2.5, 5, 10 and 20 ng) produced a dose-dependent hypotensive effect. Ang-(1-7) added to the perfusion solution (2 ng/ml) did not change the perfusion pressure or the contractile force but doubled the hypotensive effect of the lower doses of BK. The BK-potentiating...

Blastocyst-endometrium interaction: intertwining a cytokine network

Palavras-chave: Angiotensin-(1-7); Bradykinin; Coronary artery; Rat heart; L-NAME; Prostaglandins; Bradykinin potentiation.

Ano: 2000

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600012

Castro-Rendón,W.A.; Castro-Álvarez,J.F.; Guzmán-Martinez,C.; Bueno-Sanchez,J.C..

The successful implantation of the blastocyst depends on adequate interactions between the embryo and the uterus. The development of the embryo begins with the fertilized ovum, a single totipotent cell which undergoes mitosis and gives rise to a multicellular structure named blastocyst. At the same time, increasing concentrations of ovarian steroid hormones initiate a complex signaling cascade that stimulates the differentiation of endometrial stromal cells to decidual cells, preparing the uterus to lodge the embryo. Studies in humans and in other mammals have shown that cytokines and growth factors are produced by the pre-implantation embryo and cells of the reproductive tract; however, the interactions between these factors that converge for successful...

Chagas disease: Present status of pathogenic mechanisms and chemotherapy

Palavras-chave: Embryo implantation; Trophoblast; Cytokines; Prostaglandins; Aspirin.

Ano: 2006

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100001

Biol. Res.

Maya,Juan Diego; Orellana,Myriam; Ferreira,Jorge; Kemmerling,Ulrike; López-Muñoz,Rodrigo; Morello,Antonio.

There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease, where 20%-30% of infected individuals develop severe cardiopathy, with heart failure and potentially fatal arrhythmias. Currently, Chagas disease treatment is more effective in the acute phase, but does not always produce complete parasite eradication during indeterminate and chronic phases. At present, only nifurtimox or benznidazole have been proven to be superior to new drugs being tested. Therefore, it is necessary to find alternative approaches to treatment of chronic Chagas. The current treatment...

Tipo: Journal article

Palavras-chave: Chagas disease; Chemotherapy; Nifurtimox; Trypanosoma cruzi; Prostaglandins.

Ano: 2010

URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300009

Effects of two d-cloprostenol administrations given at different intervals on estrus and ovulation in cyclic dairy goats.

Eicosanoids in Insect Biology

BONATO, G. C.; CÔRTES, L. R.; ARRAIS, A. M.; FIGUEIRA, L. M.; OLIVEIRA, T. de A.; MACHADO, V. de O.; MAIA, A. L. R. e S.; SOUZA-FABJAN, J. M. G.; FONSECA, J. F. da.

Abstract: Goats are seasonal breeders depending on breed and latitude. Among the hormonal methods used in controlled reproduction programs, there are those that mimic the activity of the corpus luteum and those that inhibit it. Prostaglandin (PGF2?) fits the latter, with the advantage of having a better cost-benefit, since it is cheaper and more natural method, as it has fewer side effects than progestin devices. In addition, the literature is incipient regarding follicular and ovulatory data in goats subjected to PGF2? or its analogues. This study aimed to check in dairy goats the efficiency of estrus synchronization treatment using two doses of d-cloprostenol administered in different intervals, during the natural breeding season. The results quoted...

Tipo: Anais e Proceedings de eventos

Palavras-chave: Caprino; Cabra Leiteira; Reprodução Animal; Ovulação; Prostaglandina; Sincronização do Cio; Ciclo Estral; Dairy goats; Ovulation; Prostaglandins; Estrus synchronization; Animal reproduction.

Ano: 2019

URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1112241

Neotropical Entomology

STANLEY,DAVID W.; NOR ALIZA,A.R.; TUNAZ,HASAN; PUTNAM,SEAN M.; PARK,YOUNGJIN; BEDICK,JON C..

Prostaglandins and related eicosanoids are oxygenated metabolites of certain C20 polyunsaturated fatty acids. Eicosanoids are best understood in the context of their clinical significance in human medicine. We suggest a new and broader view of eicosanoids, which we have been calling a 'biological paradigm'. Under this view, we note that eicosanoids were taken into roles as cellular signal moieties long before the origins of the Metazoa. During the evolutionary diversification of animals, eicosanoids have been recruited into an array of biological roles, some of which occur only in insects and other invertebrates. These multiple actions endow eicosanoids with unusual explanatory power in understanding biological phenomena. We review the roles of eicosanoids...

Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis

Palavras-chave: Insect immunity; Parasitology; Prostaglandins.

Ano: 2002

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2002000300001

Paiotti,A.P.R.; Artigiani Neto,R.; Forones,N.M.; Oshima,C.T.F.; Miszputen,S.J.; Franco,M..

Ulcerative colitis (UC) is a disease of the colon and rectum characterized by a nonspecific chronic inflammation mediated by the concerted response of cellular and humoral events. Prostaglandins are synthesized by cyclooxygenase (COX)-1 and -2 and exhibit both pro- and anti-inflammatory activity. To evaluate COX-1 and COX-2 immunoexpression in 42 cases of UC and to correlate it with clinicopathological parameters, COX-1 and COX-2 expression was investigated by the immunohistochemistry method. Only patients with all pertinent clinical and evolutive data as well as with adequate biopsy material were included in the study. Fifteen samples of colorectal adenocarcinoma and 14 of large bowel with no histological changes were used for positive and negative...

Inhibition of Mayaro virus replication by prostaglandin A1 and B2 in Vero cells

Palavras-chave: Ulcerative colitis; Cyclooxygenases; Prostaglandins; Immunohistochemistry.

Ano: 2007

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700004

Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus

Ishimaru,D.; Marcicano,F.G.P.; Rebello,M.A..

The effect of prostaglandins (PGA1 and PGB2) on the replication of Mayaro virus was studied in Vero cells. PGA1 and PGB2 antiviral activity was found to be dose-dependent. However, while 10 µg/ml PGB2 inhibited virus yield by 60%, at the same dose PGA1 suppressed virus replication by more than 90%. SDS-PAGE analysis of [35S]-methionine-labelled proteins showed that PGA1 did not alter cellular protein synthesis. In infected cells, PGA1 slightly inhibited the synthesis of protein C, while drastically inhibiting the synthesis of glycoproteins E1 and E2.

Tipo: Info:eu-repo/semantics/other

Palavras-chave: Prostaglandins; Mayaro virus; Vero cells; Protein synthesis.

Ano: 1998

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900003

BJM

Caldas,Lúcio Ayres; Freitas,Tânia Rosária Pereira; Azevedo,Renata Campos; de Souza,Wanderley.

ABSTRACT Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 µg/mL).

Prostanoids modulate inflammation and alloimmune responses during graft rejection

Palavras-chave: Bovine viral diarrhea virus; BVDV; Prostaglandins; Prostaglandin A1; Virus-induced vacuolization.

Ano: 2018

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000400785

Rocha,P.N.; Carvalho,E.M..

Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief...

Reproductive parameters of dairy goats submitted to estrus synchronization with prostaglandin F2alfa associated or not to hCG at estrous onset.

Palavras-chave: Thromboxane; Prostaglandins; Transplantation; Inflammation; Rejection; Corticosteroids.

Ano: 2005

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200004

Sincronização do estro de novilhas caprinas mestiças com PGF2a: dose e sub-dose em duas vias de aplicação.

ESTEVES, L. V.; BRANDÃO, F. Z.; CRUZ, R. C.; SOUZA, J. M. G.; OBA, E.; FACO, O.; FONSECA, J. F. da.

Abstract: The objective of this study was to evaluate the efficiency of two doses of PGF associated or not to hCG on the associated reproductive parameters in dairy goats. A total of 29 goats received two doses of 30 ug d-cloprostenol latero-vulvar at a 10 day intervals (Day 1 and Day 10). The does were allocated according to body weight and body condition score into two treatments, to receive hCG (250IU) or saline at estrus onset. After the second dose of PGF, estrus was monitored and ultrasound exams were performed twice daily. All does were inseminated 16h after estrus onset. Blood collection was performed every day for progesterone assay. The use of hCG at estrus onset did not affect any studied parameter and therefore the data were pooled. Estrous...

Tipo: Artigo de periódico

Palavras-chave: D-cloprostenol; Sexual behaviour; HCG; PGF; Animal behaviour; Oestrous cycle; Oestrus synchronization.; Caprino; Cabra leiteira; Inseminação artificial; Sincronização do cio; Ciclo estral; Comportamento sexual; Prostaglandina; Progesterona; Hormônio; Goats; Artificial insemination; Progesterone; Prostaglandins; Hormones..

Ano: 2013

URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/972787

The influence of dietary supplementation of arachidonic acid on prostaglandin production and oxidative stress in the Pacific oyster Crassostrea gigas

REGO, J. P. A.; SANTOS, D. O.; FARIAS, L. S.; OLIVEIRA, L. S..

Atualmente avalia-se a viabilidade de diferentes protocolos de sincronização do estro com PGF2a isolada, na redução de custos; buscando dose e via de aplicação eficazes, ampliando sua utilização na reprodução animal (FRAZÃO et al,2006). O emprego de sub-doses de PGF2a aplicadas intravulvarmente tem sido uma alternativa para reduzir custos. MGONGO (1988) verificou que, a redução nos níveis de progesterona sangüíneos, em cabras após aplicação de 125 mg de cloprostenol, via intramuscular, era semelhante àquela verificadas em fêmeas que receberam sub-dose (62,5 mg) por via submucosa vulvar. HEAP et al. (1985) demonstraram que a rapidez de difusão da PGF2a produzida no útero em direção aos ovários era devido, principalmente, aos sistemas linfático e sangüíneo...

Tipo: Anais e Proceedings de eventos

Palavras-chave: Brasil; Ceará; Sobral; Oestrus synchronization; PGF 2 alpha.; Caprino; Ciclo Estral; Diagnostico; Inseminação Artificial; Prenhez; Reprodução Animal; Fertilidade.; Sincronização do Cio; Crossbreds; Brazil; Animal fertility; Animal reproduction.; Prostaglandins; Goats.

Ano: 2007

URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/530591

ArchiMer

Seguineau, Catherine; Racotta, Ilie; Palacios, Elena; Delaporte, Maryse; Moal, Jeanne; Soudant, Philippe.

In a previous study, dietary supplementation with arachidonic acid (ARA) to oysters Crassostrea gigas increased haemocyte numbers, phagocytosis, and production of reactive oxygen species level (ROS) by haemocytes (Delaporte et al., 2006). To assess if the observed stimulation of these cellular responses resulted from changes of ARA-related prostaglandin (PG) production, we analysed prostaglandin E2 metabolite (PGEM) content on the same oysters fed three levels of ARA. Dietary supply of polyunsaturated fatty acids (PUFA) could also induce an oxidative stress that could similarly increase cellular responses; therefore, two indicators of oxidative stress were analysed: peroxidation level and antioxidant defence status. Together the observed positive...

Tipo: Text

Palavras-chave: Prostaglandins; N-6 unsaturated fatty acids; Lipid peroxidation; Antioxidants; ROS production.

Ano: 2011

URL: http://archimer.ifremer.fr/doc/00040/15103/12785.pdf

The role of prostaglandin F2a on ovulation and LH release in cows.

Use of D-Cloprostenol at different intervals of administration for estrous synchronization in cyclic Saanen goats.

CASTRO, N. A. de; LEONARDI, C. E. P.; SINGH, J.; SCHNEIDER, A.; GONÇALVES, P. B.; OLIVEIRA, F. C.; D'ÁVILA, C. A.; FERREIRA, R.; GASPERIN, B. G.; MOREIRA, E. M.; ANDRADE, J. de S.; PFEIFER, L. F. M..

This study aimed to evaluate the role of prostaglandin F2a (PGF) on ovulation. In Experiment 1, cows were randomly allocated to two treatments to receive 150 ug of d-Cloprostenol (PGF Group, n = 12) or 2 mL of NaCl 0.9% (Control Group, n = 11) and CIDRs, were removed 4 days later. No cow ovulated in Control and PGF groups. In Experiment 2, cows were randomly separated into two experimental groups to receive 4 injections of 150 ug of d-Cloprostenol (n = 9) or 2 mL of NaCL 0.9% (n = 9). In this experiment, ovulation was not observed in any cows. In Experiment 3, ovariectomized cows receive three injections of 300ug of PGF analog (PGF Group, n = 5), 100ug of Lecirelin (GnRH Group, n = 5) or 2 mL of PBS (Control Group, n = 4). The LH concentration was higher...

Tipo: Artigo de periódico

Palavras-chave: F2a; Reprodução Animal; Vaca; Ovulação; Prostaglandina; Animal reproduction; Cows; Ovulation; Prostaglandins.

Ano: 2021

URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1131796

Uso do c-cloprostenol em diferentes intervalos de aplicação para sincronização do estro em cabras Saanen.

MAIA, A. L. R. S.; BRANDÃO, F. Z.; SANTOS, G. B.; BALARO, M. F. A.; RODRIGUES, A. L. R.; FONSECA, J. F. da; FACO, O..

Proceedings of the 28th Annual Meeting of The Brazilian Embryo Technology Society - SBTE, Natal, RN, Brasil, ago. 2014.

Tipo: Parte de livro

Palavras-chave: Raça Saanen; Oestrous cycle; Reproduction control.; Oestrus synchronization; Caprino; Reprodução animal; Inseminação artificial; Prostaglandina; Sincronização do cio; Ciclo estral; Goats; Reproduction; Artificial insemination; Prostaglandins; Hormones..

Ano: 2014

URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/993422