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| Wrutniak, C.; Cassar-Malek, I.; Marchal, S.; Rascle, A.; Heusser, S.; Keller, J.M.; Fléchon, J.; Dauça, M.; Samarut, J.; Ghysdael, J.; Cabello, G.. |
| Tipo: Journal Article |
Palavras-chave: RECEPTEUR NUCLEAIRE; ACTIVITE MITOCHONDRIALE; FOIE. |
| Ano: 1995 |
URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB9600002381054657&uri=/notices/prodinra1/2010/09/ |
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| Robinson-Rechavi, M.; Maina, C.V.; Gissendanner, C.R.; Laudet, V.; Sluder, A.. |
| The nuclear receptor superfamily expanded in at least two episodes: one early in metazoan evolution, the second within the vertebrate lineage. An exception to this pattern is the genome of the nematode Caenorhabditis elegans, which encodes more than 270 nuclear receptors, most of them highly divergent. We generated 128 cDNA sequences for 76 C. elegans nuclear receptors, confirming that these are active genes. Among these numerous receptors are 13 orthologues of nuclear receptors found in arthropods and/or vertebrates. We show that the supplementary nuclear receptors (supnrs) originated from an explosive burst of duplications of a unique orphan receptor, HNF4. This origin has specific implications for the role of ligand binding in the function and evolution... |
| Tipo: Journal Article |
Palavras-chave: NEMATODE; RECEPTEUR NUCLEAIRE; EVOLUTION; POLYGENIE DEVELOPMENT; DUPLICATION; ENDOCRINOLOGY; EVOLUTIONARY RATE; PHYLOGENY; TRANSCRIPTION FACTOR. |
| Ano: 2005 |
URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20089c9e48c5&uri=/notices/prodinra1/2010/11/ |
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