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	Provedor de dados OAK (1) Autor Hashimoto, Makoto (1) Hatanaka, Yasumaru (1) Nabeta, Kensuke (1) Sadakane, Yutaka (1) Palavra-chave DIAZIRINE (1) DOMAIN (1) FLAVIN BINDING-SITES (1) IDENTIFICATION (1) PHOTOAFFINITY (1) PROTEINS (1) RECEPTOR (1) Mais... Ano 2002 (1) País Japan (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Synthesis of tag introducible (3-trifluoromethyl)phenyldiazirine based photoreactive phenylalanine OAK Hashimoto, Makoto; Hatanaka, Yasumaru; Sadakane, Yutaka; Nabeta, Kensuke. An efficient synthesis of tag introducible (3-trifluoromethyl)phenyldiazirine based phenylalanine derivatives is described. Alkylation of a chiral glycine equivalent with a spacer containing (3-trifluoromethyl)phenyldiazirinyl bromides enables us to create photoreactive L-phenylalanine derivatives. After introduction of biotin at the spacer, the biotinylated and photoreactive amino acid was applied for L-amino acid oxidase and incorporated into a substrate binding site. These compounds will be powerful tools not only for photoaffinity labeling to elucidate properties of bioactive peptides but also as trifunctional photophors to introduce a ligand skeleton. (C) 2002 Elsevier Science Ltd. All rights reserved. Palavras-chave: FLAVIN BINDING-SITES; PHOTOAFFINITY; DIAZIRINE; IDENTIFICATION; PROTEINS; RECEPTOR; DOMAIN. Ano: 2002 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/713 Registros recuperados: 1 Primeira ... 1 ... Última

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