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Registros recuperados: 13
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A Review of Scientific Papers About Head and Neck Cancers BABT
Paoli,Severo de; Fonseca,Adenilson de Souza da; Paoli,Flávia de; Geller,Mauro; Presta,Giuseppe Antonio; Santos-Filho,Sebastião David; Bernardo-Filho,Mário.
Head and neck cancer is one of the 10 most frequent cancers worldwide, with an estimated 500000 new cases diagnosed annually. Treatment of head and neck cancers require a multidisciplinary approach due their complexity and the functional and esthetic alterations that cancer can cause. The interest of the scientific community in a specific subject can be evaluated by analyzing of the number and the quality of published papers on the topic. The information obtained from PubMed (www.ncbi.nlm.nih.gov/sites/entrez) has been used as a tool in various publications to aid the evaluation of the scientific interest in specific research areas The aim of this work is to evaluate, using PubMed, the scientific interest in studies of head and neck cancer treatments such...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scientific interest; PubMed; Cancer; Surgery; Radiotherapy; Chemotherapy.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700011
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A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group BJMBR
Santini,G.; De Souza,C.; Aversa,S.; Patti,C.; Tedeschi,L.; Candela,M.; Olivieri,A.; Chisesi,T.; Rubagotti,A.; Centurioni,R.; Nardi,V.; Congiu,M.; Gennaro,M.; Truini,M..
The objective of this multicenter prospective study was to determine the clinical efficacy and toxicity of a polychemotherapeutic third generation regimen, VACOP-B, with or without radiotherapy as front-line therapy in aggressive localized non-Hodgkin's lymphoma. Ninety-three adult patients (47 males and 46 females, median age 45 years) with aggressive localized non-Hodgkin's lymphoma, 43 in stage I and 50 in stage II (non-bulky), were included in the study. Stage I patients received VACOP-B for 6 weeks plus involved field radiotherapy and stage II patients received 12 weeks VACOP-B plus involved field radiotherapy on residual masses. Eighty-six (92.5%) achieved complete remission and 4 (4.3%) partial remission. Three patients (3.2%) were primarily...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Localized aggressive non-Hodgkin's lymphoma; VACOP-B; Radiotherapy; Toxicity.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500014
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Aptamer-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of epithelial tumors BABT
Missailidis,Sotiris; Perkins,Alan; Santos-Filho,Sebastião David; Fonseca,Adenilson de Souza da; Bernardo-Filho,Mario.
In the continuous search for earlier diagnosis and improved therapeutic modalities against cancer, based on our constantly increasing knowledge of cancer biology, aptamers hold the promise to expand on current antibody success, but overcoming some of the problems faced with antibodies as therapeutic or delivery agents in cancer. However, as the first aptamer reached the market as an inhibitor against angiogenesis for the treatment of macular degeneration, aptamers have found only limited applications or interest in oncology, and even less as radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of tumours. Yet, the chemistry for the labelling of aptamers and the options to alter their pharmacokinetic properties, to make them suitable for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aptamer; Radiopharmaceutical; Diagnostic imaging; Radiotherapy; Epithelial tumor.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700013
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Biological X-ray irradiator characterization for use with small animals and cells BJMBR
Bruno,A. Colello; Mazaro,S.J.; Amaral,L.L.; Rego,E.M.; Oliveira,H.F.; Pavoni,J.F..
This study presents the characterization of an X-ray irradiator through dosimetric tests, which confirms the actual dose rate that small animals and cells will be exposed to during radiobiological experiments. We evaluated the linearity, consistency, repeatability, and dose distribution in the positions in which the animals or cells are placed during irradiation. In addition, we evaluated the performance of the X-ray tube (voltage and tube operating current), the radiometric survey (leakage radiation) and safety devices. The irradiator default setting was established as 160 kV and 25 mA. Tests showed that the dose rate was linear overtime (R2=1) and remained stable for long (constant) and short (repeatability) intervals between readings. The mean dose rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: X-ray irradiator; Dosimetric characterization; Radiotherapy; Dosimetry; Radiochromic film.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000300607
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Common Deletion (CD) in mitochondrial DNA of irradiated rat heart Anais da ABC (AABC)
SIQUEIRA,RAQUEL G.; SILVA,DAYSE A. DA; MELO,LUIZ D.B. DE; CARVALHO,ELIZEU F. DE; FERREIRA-MACHADO,SAMARA C.; ALMEIDA,CARLOS E.V. DE.
The purpose of this study was to map the common deletion (CD) area in mtDNA and investigate the levels of this deletion in irradiated heart. The assays were developed in male Wistar rats that were irradiated with three different single doses (5, 10 or 15 Gy) delivered directly to the heart and the analyses were performed at various times post-irradiation (3, 15 or 120 days). The CDs area were sequenced and the CD quantified by real-time PCR. Our study demonstrated that the CD levels progressively decreased from the 3rduntil the 15th day after irradiation, and then increased thereafter. Additionally, it was observed that the levels of CD are modulated differently according to the different categories of doses (moderate and high). This study demonstrated an...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiovascular complications; Common mitochondrial DNA deletion; Mediastinal tumours; Radiotherapy.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000200685
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Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients Biol. Res.
Ozden,Sevgi; Tiber,Pinar Mega; Ozgen,Zerrin; Ozyurt,Hazan; Serakinci,Nedime; Orun,Oya.
BACKGROUND: Telomeres are protective caps consisted of specific tandem repeats (5′-TTAGGG-3′). Shortening of telomeres at each cell division is known as "mitotic clock" of the cells, which renders telomeres as important regulators of lifespan. TRF2 is one of the critical members of shelterin complex, which is a protein complex responsible from the preservation of cap structure, and loss or mutation of TRF2 results in DNA damage, senescence or apoptosis. Since cancer is frequently associated with aberrant cell cycle progression, defective DNA repair or apoptosis pathways, TRF2 could be one likely candidate for cancer therapy. Here we investigated the prognostic role of TRF2 levels in cervical cancer patients. Fold-induction rates were...
Tipo: Journal article Palavras-chave: Cervical cancer; Radiotherapy; Telomere repeat-binding factors 2; B-cell lymphoma-extra large; Apoptosis.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100055
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Neuropathic pain and prognosis of a dog submitted to limb amputation after diagnosis of soft tissue sarcoma - case report Arq. Bras. Med. Vet. Zootec.
Ferreira,M.G.P.A.; Antunes,A.V.; Pascoli,A.L.; Nazaret,T.L.; Gering,A.P.; Reis Filho,N.P.; Costa,M.T.; Nardi,A.B..
ABSTRACT Neuropathic pain occurs when there is a lesion or a dysfunction of the nervous system. Humans and veterinary patients may develop neuropathic pain, but in veterinary it is not often reported probably because of its mistaken diagnosis. A canine patient was admitted to the Veterinary Hospital of UNESP-Jaboticabal-SP, Brazil with a nodule on the left thoracic limb. The nodule was surgically removed, and histopathological analysis demonstrated the tumor was a soft tissue sarcoma (STS) and the margins were not clean. Based on the patient’s health condition and the lack of suitable equipment, the next procedure was limb amputation. The patient received analgesic medication in the post-surgery period; nevertheless, clinical signs of neuropathic pain were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Analgesia; Oncology; Phantom limb; Radiotherapy; Tumor.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000401116
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Occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing head and neck radiotherapy BJM
Gaetti-Jardim Júnior,Elerson; Ciesielski,Francisco Isaak Nicolas; Sousa,Fátima Regina Nunes de; Nwaokorie,Francisca; Schweitzer,Christiane Marie; Avila-Campos,Mario Júlio.
The aim of this study was to evaluate the occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing radiotherapy (RT) for treatment of head and neck cancer. Fifty patients receiving RT were examined before, during and 30 days after RT. Saliva, mucosa, and biofilm samples were collected and microorganisms were detected by culture and polymerase chain reaction (PCR). The most prevalent yeasts in patients submitted to RT were Candida albicans, C. tropicalis, C. krusei, C. glabrata and C. parapsilosis. Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, and Pseudomonas were the most frequently cultivated bacteria. Before RT, targeted bacteria were cultivated from 22.2% of edentulous patients and 16.6% of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiotherapy; Cancer; Enterobacteriaceae; Prevalence.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000300024
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Prostate cancer, treatment modalities and complications: an evaluation of the scientific literature BABT
Santos-Filho,Sebastião David; Missailids,Sotiris; Fonseca,Adenilson de Souza da; Bernardo-Filho,Mario.
Prostate (PR) cancer (CA) is one of the most common malignant neoplasms in men all over the world. In general, if prostate cancer (PC) is detected early, treatment usually involves either surgical removal of the prostate or radiotherapy (RT). Hormone Therapy (HT) or chemotherapy (CH) is the preferred treatment for more advanced cases of PC or if CA spreads beyond the PT. A number of complications, such as urinary incontinence (IU) or erectile dysfunction (ED), can be associated with some modalities of treatment of the PC. The aim of this work is to evaluate, in PubMed, the number of publications related with prostate cancer and the main modalities of treatment, as well as some clinical complications. The searches were performed in PubMed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Prostate cancer; Radiotherapy; PubMed; Scientific interest.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700009
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Radiotherapy, cancer and some anatomical structures related with the pelvic floor: an evaluation of the scientific literature BABT
Santos-Filho,Sebastião David; Presta,Giuseppe Antonio; Paoli,Severo de; Missailids,Sotiris; Fonseca,Adenilson de Souza da; Bernardo-Filho,Mario.
Radiotherapy is a cancer treatment that uses high-energy X-rays or other types of ionizing radiation to try to kill the cancer cells in various organs/tissues. PubMed is a database used as a tool in various publications. The aim of this work was to evaluate, in the PubMed, the number of publications (NP) in radiotherapy and cancer in various organs related to the pelvic floor as well as brachytherapy. The searches were performed (August 2008) in the PubMed (http://www.pubmed.com) using the words: (i) radiotherapy (RT) or cancer (CA), (ii) RT and CA, (iii) RT and CA and prostate, RT and CA and testis, RT and CA and breast, RT and CA and kidneys, RT and CA and vulva, RT and CA and vagina, RT and CA and penis, RT and CA and uterus, RT and CA and ovary, RT and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiotherapy; Cancer; Pelvic floor; PubMed; Scientific interest.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700008
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Radiotherapy modulates expression of EGFR, ERCC1 and p53 in cervical cancer BJMBR
de Almeida,V.H.; de Melo,A.C.; Meira,D.D.; Pires,A.C.; Nogueira-Rodrigues,A.; Pimenta-Inada,H.K.; Alves,F.G.; Moralez,G.; Thiago,L.S.; Ferreira,C.G.; Sternberg,C..
Cervical cancer is a public health problem and the molecular mechanisms underlying radioresistance are still poorly understood. Here, we evaluated the modulation of key molecules involved in cell proliferation, cell cycle and DNA repair in cervical cancer cell lines (CASKI and C33A) and in malignant tissues biopsied from 10 patients before and after radiotherapy. The expression patterns of epidermal growth factor receptor (EGFR), excision repair cross-complementation group 1 (ERCC1) and p53 were evaluated in cancer cell lines by quantitative PCR and western blotting, and in human malignant tissues by immunohistochemistry. The mutation status of TP53 gene was evaluated by direct sequencing. Among cell lines, absent or weak modulations of EGFR, ERCC1 and p53...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cervical cancer; Radiotherapy; Epidermal growth factor receptor (EGFR); P53; Excision repair cross-complementation group 1 (ERCC1).
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100608
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Three-dimensional conformal breast irradiation in the prone position BJMBR
Kurtman,C.; Andrieu,M. Nalça; Hiçsönmez,A.; Çelebioglu,B..
The prone position can be used for the planning of adjuvant radiotherapy after conservative breast surgery in order to deliver less irradiation to lung and cardiac tissue. In the present study, we compared the results of three-dimensional conformal radiotherapy planning for five patients irradiated in the supine and prone position. Tumor stage was T1N0M0 in four patients and T1N1M0 in one. All patients had been previously submitted to conservative breast surgery. Breast size was large in three patients and moderate in the other two. Irradiation in the prone position was performed using an immobilization foam pad with a hole cut into it to accommodate the breast so that it would hang down away from the chest wall. Dose-volume histograms showed that mean...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Prone position; Breast cancer; Radiotherapy.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000023
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Treatment delay and radiological errors in patients with bone metastases BJMBR
Ichinohe,K.; Takahashi,M.; Tooyama,N..
During routine investigations, we are surprised to find that therapy for bone metastases is sometimes delayed for a considerable period of time. To determine the extent of this delay and its causes, we reviewed the medical records of symptomatic patients seen at our hospital who had been recently diagnosed as having bone metastases for the last four years. The treatment delay was defined as the interval between presentation with symptoms and definitive treatment for bone metastases. The diagnostic delay was defined as the interval between presentation with symptoms and diagnosis of bone metastases. The results of diagnostic radiological examinations were also reviewed for errors. The study population included 76 males and 34 females with a median age of 66...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone metastases; Delay; Radiology; Error; Radiotherapy.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000020
Registros recuperados: 13
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