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Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels BJMBR
Chinen,R.; Câmara,N.O.S.; Nishida,S.; Silva,M.S.; Rodrigues,D.A.; Pereira,A.B.; Pacheco-Silva,A..
Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were re-analyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54% according to criteria used to define it...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Renal function; Urinary retinol-binding protein; Heart transplant; Graft survival; Chronic renal failure.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000006
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Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats BJMBR
Abreu,N.P.; Bergamaschi,C.T.; di Marco,G.S.; Razvickas,C.V.; Schor,N..
The objective of the present study was to evaluate the role of physical exercise as well as the influence of hydration with an isotonic sports drink on renal function in male Wistar rats. Four groups were studied over a period of 42 days: 1) control (N = 9); 2) physical exercise (Exe, N = 7); 3) isotonic drink (Drink, N = 8); 4) physical exercise + isotonic drink (Exe + Drink, N = 8). Physical exercise consisted of running on a motor-driven treadmill for 1 h/day, at 20 m/min, 5 days a week. The isotonic sports drink was a commercial solution used by athletes for rehydration after physical activity, 2 ml administered by gavage twice a day. Urine cultures were performed in all animals. Twenty-four-hour urine samples were collected in metabolic cages at the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Renal function; Isotonic rehydration sports drink; Physical activity; Renal stone; Nephrolithiasis; Tamm-Horsfall protein.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400011
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Effect of chronic fish oil supplementation on renal function of normal and cachectic rats BJMBR
Fernandez,R.; Piechnik,J.; Fabris,R.; Malnic,G.; Fernandes,L.C..
In the present study we determined the effect of chronic diet supplementation with n-3 PUFA on renal function of healthy and cachectic subjects by providing fish oil (1 g/kg body weight) to female rats throughout pregnancy and lactation and then to their offspring post-weaning and examined its effect on renal function parameters during their adulthood. The animals were divided into four groups of 5-10 rats in each group: control, control supplemented with fish oil (P), cachectic Walker 256 tumor-bearing (W), and W supplemented with fish oil (WP). Food intake was significantly lower in the W group compared to control (12.66 ± 4.24 vs 25.30 ± 1.07 g/day). Treatment with fish oil significantly reversed this reduction (22.70 ± 2.94 g/day). Tumor growth rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fish oil supplementation; Renal function; Cachexia; Walker 256 tumor; Sodium excretion; Glomerular filtration rate.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000006
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Effect of D-alpha-tocopherol on tubular nephron acidification by rats with induced diabetes mellitus BJMBR
Nascimento Gomes,G.; Barbosa,F.T.; Radaeli,R.F.; Cavanal,M.F.; Mello Aires,M.; Zaladek Gil,F..
The objective of the present study was to determine if treatment of diabetic rats with D-alpha-tocopherol could prevent the changes in glomerular and tubular function commonly observed in this disease. Sixty male Wistar rats divided into four groups were studied: control (C), control treated with D-alpha-tocopherol (C + T), diabetic (D), and diabetic treated with D-alpha-tocopherol (D + T). Treatment with D-alpha-tocopherol (40 mg/kg every other day, ip) was started three days after diabetes induction with streptozotocin (60 mg/kg, ip). Renal function studies and microperfusion measurements were performed 30 days after diabetes induction and the kidneys were removed for morphometric analyses. Data are reported as means ± SEM. Glomerular filtration rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; D-alpha-tocopherol; Renal function; Nephropathy.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700007
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Effect of intraperitoneally administered hydrolyzed whey protein on blood pressure and renal sodium handling in awake spontaneously hypertensive rats BJMBR
Costa,E.L.; Almeida,A.R.; Netto,F.M.; Gontijo,J.A.R..
The present study evaluated the acute effect of the intraperitoneal (ip) administration of a whey protein hydrolysate (WPH) on systolic arterial blood pressure (SBP) and renal sodium handling by conscious spontaneously hypertensive rats (SHR). The ip administration of WPH in a volume of 1 ml dose-dependently lowered the SBP in SHR 2 h after administration at doses of 0.5 g/kg (0.15 M NaCl: 188.5 ± 9.3 mmHg vs WPH: 176.6 ± 4.9 mmHg, N = 8, P = 0.001) and 1.0 g/kg (0.15 M NaCl: 188.5 ± 9.3 mmHg vs WPH: 163.8 ± 5.9 mmHg, N = 8, P = 0.0018). Creatinine clearance decreased significantly (P = 0.0084) in the WPH-treated group (326 ± 67 µL min-1 100 g body weight-1) compared to 0.15 M NaCl-treated (890 ± 26 µL min-1 100 g body weight-1) and captopril-treated (903...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Arterial blood pressure; Hydrolysis; Renal function; Urinary sodium excretion; Whey protein isolate.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200010
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Effect of metabolic acidosis on renal tubular sodium handling in rats as determined by lithium clearance BJMBR
Menegon,L.F.; Figueiredo,J.F.; Gontijo,J.A.R..
Systemic metabolic acidosis is known to cause a decrease in salt and water reabsorption by the kidney. We have used renal lithium clearance to investigate the effect of chronic, NH4Cl-induced metabolic acidosis on the renal handling of Na+ in male Wistar-Hannover rats (200-250 g). Chronic acidosis (pH 7.16 ± 0.13) caused a sustained increase in renal fractional Na+ excretion (267.9 ± 36.4%), accompanied by an increase in fractional proximal (113.3 ± 3.6%) and post-proximal (179.7 ± 20.2%) Na+ and urinary K+ (163.4 ± 5.6%) excretion when compared to control and pair-fed rats. These differences occurred in spite of an unchanged creatinine clearance and Na+ filtered load. A lower final body weight was observed in the acidotic (232 ± 4.6 g) and pair-fed (225 ±...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Renal function; Renal sodium excretion; Lithium clearance; Metabolic acidosis.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000006
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Effect of strenuous maternal exercise before and during pregnancy on rat progeny renal function BJMBR
Oliveira,A.O.; Fileto,C.; Melis,M.S..
The effects of strenuous exercise before and during pregnancy on the renal function and morphological alterations of the progeny were determined in a study on female Wistar rats. This research was done based on a previous study carried out in our laboratory, which showed morphological alterations in rats submitted to this kind of exercise. As the form is related to the function, the physiological relevance of submitting a pregnant female to a high-intensity exercise training regimen could be explained by the fact that morphological alterations can influence kidney function. The animals were assigned to one of two groups: control animals that did not exercise during pregnancy and trained animals that swam for 120 min 5 days a week for 8 weeks before...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Renal function; Exercise during pregnancy; Fetus; Gestation.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600017
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Effect of thyroparathyroidectomy on urinary acidification in diabetic rats BJMBR
Zaladek-Gil,F.; Cavanal,M.F.; Nascimento-Gomes,G.; Silva-Rocha,M.C.; Nutti-de-Almeida,M..
In previous studies we have shown stimulation of renal acid excretion in the proximal tubules of rats with diabetes of short duration, with no important alterations in glomerular hemodynamics; on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. Since important changes in the parathyroid hormone-vitamin D-Ca axis are observed in the diabetic state, the present study was undertaken to investigate the renal repercussions of thyroparathyroidectomy in rats previously made diabetic by streptozotocin (45 mg/kg). Four to 6 days after the induction of diabetes (DM), a group of rats were thyroparathyroidectomized (DM + TPTX)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Thyroparathyroidectomy; Renal function; Acid excretion.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100016
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Effects of dietary lipids on renal function of aged rats BJMBR
Valente Gamba,C.; Zeraib Caraviello,A.; Matsushita,A.; Alves,G.M.; Nunes da Silva,L.; Nascimento Gomes,G.; Zaladek Gil,F..
Normal aging is accompanied by renal functional and morphological deterioration and dietetic manipulation has been used to delay this age-related decline. We examined the effects of chronic administration of diets containing 5% lipid-enriched diet (LD, w/w) on renal function of rats at different ages. Three types of LD were tested: canola oil, fish oil and butter. Mean systemic tail-cuff blood pressure and glycemia remained within the normal range whatever the age and the diet of the animals. Proteinuria began to rise from the 8th month in the groups ingesting LD, while in the control group it increased significantly (above 10 mg/24 h) only after the 10th month. With age, a significant and progressive decline in glomerular filtration rate (GFR) and renal...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Aging; Lipids; Proteinuria; Renal function; Acid excretion; Canola oil; Fish oil.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200016
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Gender-dependent effects of aging on the kidney BJMBR
Gava,A.L.; Freitas,F.P.S.; Meyrelles,S.S.; Silva,I.V.; Graceli,J.B..
It is well known that the kidney plays an important role in the development of cardiovascular diseases such as hypertension. The normal aging process leads to changes in kidney morphology, hemodynamics and function, which increase the incidence of cardiovascular events in the elderly population. These disturbances are influenced by several factors, including gender. In general, females are protected by the effects of estrogens on the cardiorenal system. Several studies have demonstrated the beneficial effects of estrogens on renal function in the elderly; however, the relationships between androgens and kidney health during one’s lifetime are not well understood. Sex steroids have many complex actions, and the decline in their levels during aging clearly...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sexual dimorphism; Renal function; Aging; Cardiovascular disorders; Sex hormones.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900012
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Renal dysfunction in patients with sickle cell anemia or sickle cell trait BJMBR
Sesso,R.; Almeida,M.A.; Figueiredo,M.S.; Bordin,J.O..
Patients with sickle cell anemia (Hb SS) or sickle cell trait (Hb AS) may present several types of renal dysfunction; however, comparison of the prevalence of these abnormalities between these two groups and correlation with the duration of disease in a large number of patients have not been thoroughly investigated. In a cross-sectional study using immunoenzymometric assays to measure tubular proteinuria, microalbuminuria, measurement of creatinine clearance, urinary osmolality and analysis of urine sediment, we evaluated glomerular and tubular renal function in 106 adults and children with Hb SS (N = 66) or Hb AS (N = 40) with no renal failure (glomerular filtration rate (GFR) >85 ml/min). The percentage of individuals with microalbuminuria was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Microalbuminuria; Renal failure; Renal function; Sickle cell disease.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000004
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Seasonal changes in the use of marine food resources by Cinclodes nigrofumosus (furnariidae, aves): carbon isotopes and osmoregulatory physiology RChHN
SABAT,PABLO; MARTÍNEZ DEL RÍO,CARLOS.
Passerines lack functional salt glands and to a large extent avoid feeding on marine invertebrates. An exception is Cinclodes nigrofumosus. Previous studies reported that the contents of its gastrointestinal tract had a lower osmolality than seawater suggesting that birds were supplementing their marine invertebrate diet with terrestrial invertebrates and fresh water at certain periods of the year. We report seasonal changes in the diet of C. nigrofumosus at two contrasting coastal localities in Central Chile and document the potential correlation between weather and feeding habits with osmoregulatory features in this species. We expected that C. nigrofumosus would increase its use of osmotically challenging marine dietary sources when fresh water is...
Tipo: Journal article Palavras-chave: Cinclodes; Isotopes; Renal function; Osmoregulation; Seasonal changes.
Ano: 2005 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2005000200009
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