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	Provedor de dados Biocell (1) BJMBR (1) Autor Hong,S. (1) Hong,Samin (1) Iizuka,Y. (1) Kim,C.Y. (1) Kim,Chan Yun (1) Lee,J.E. (1) Park,Kyoungsoo (1) Seong,G.J. (1) Seong,Gong Je (1) Yang,W.I. (1) Mais... Palavra-chave Agmatine (2) Retinal ganglion cell (2) Hypoxia (1) Neuroprotection (1) Oxidative stress (1) Tumor necrosis factor-alpha (1) Mais... Tipo do documento Info:eu-repo/semantics/other (2) Ano 2010 (1) 2008 (1) País Argentina (1) Brazil (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells Biocell Hong,Samin; Park,Kyoungsoo; Kim,Chan Yun; Seong,Gong Je. The effect of hypoxia on the release of tumor necrosis factor-alpha (TNF-alpha) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-alpha in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100μM agmatine. The expression levels of TNF-alpha and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-alpha production in RGCs. Agmatine significantly reduced TNF-alpha level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-alpha production of RGCs in hypoxic... Tipo: Info:eu-repo/semantics/other Palavras-chave: Retinal ganglion cell; Tumor necrosis factor-alpha; Hypoxia; Agmatine. Ano: 2008 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200006 Protective mechanism of agmatine pretreatment on RGC-5 cells injured by oxidative stress BJMBR Iizuka,Y.; Hong,S.; Kim,C.Y.; Yang,W.I.; Lee,J.E.; Seong,G.J.. Agmatine has neuroprotective effects on retinal ganglion cells (RGCs) as well as cortical and spinal neurons. It protects RGCs from oxidative stress even when it is not present at the time of injury. As agmatine has high affinity for various cellular receptors, we assessed protective mechanisms of agmatine using transformed RGCs (RGC-5 cell line). Differentiated RGC-5 cells were pretreated with 100 μM agmatine and consecutively exposed to 1.0 mM hydrogen peroxide (H2O2). Cell viability was determined by measuring lactate dehydrogenase (LDH), and the effects of selective alpha 2-adrenergic receptor antagonist yohimbine (0-500 nM) and N-methyl-D-aspartic acid (NMDA) receptor agonist NMDA (0-100 µM) were evaluated. Agmatine’s protective effect was compared to... Tipo: Info:eu-repo/semantics/other Palavras-chave: Agmatine; Neuroprotection; Oxidative stress; Retinal ganglion cell. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400006 Registros recuperados: 2 Primeira ... 1 ... Última

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