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Registros recuperados: 15
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Analysis of radioprotection and antimutagenic effects of Ilex paraguariensis infusion and its component rutin BJMBR
Bracesco,N.; Sosa,V.; Blanc,L.; Contreras,V.; Candreva,E.C.; Salvo,V.A.; Hocart,S.; Mechoso,B.; Nunes,E..
DNA repair pathways, cell cycle checkpoints, and redox protection systems are essential factors for securing genomic stability. The aim of the present study was to analyze the effect of Ilex paraguariensis (Ip) infusion and one of its polyphenolic components rutin on cellular and molecular damage induced by ionizing radiation. Ip is a beverage drank by most inhabitants of Argentina, Paraguay, Southern Brazil, and Uruguay. The yeast Saccharomyces cerevisiae (SC7Klys 2-3) was used as the eukaryotic model. Exponentially growing cells were exposed to gamma rays (γ) in the presence or absence of Ip or rutin. The concentrations used simulated those found in the habitual infusion. Surviving fractions, mutation frequency, and DNA double-strand breaks (DSB) were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiation damage; Ilex paraguariensis infusion; Rutin; Radioprotection; Antimutagenic effects; Saccharomyces cerevisiae.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900606
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Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice BJPS
Ozbek,Hanefi; Acikara,Ozlem Bahadir; Oz,Burcin Ergene; Ozbilgin,Serkan; Kirmizi,Neriman Ipek; Ozrenk,Bade Cevriye; Tekin,Mehmet; Saltan,Gulcin.
In the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for their antidiabetic activities. Methanol water extracts of the aerial parts were used for experiments. An alloxan-induced diabetic mice test model was used. Phytochemical analysis of the tested extracts was investigated using the HPLC method. The highest activity was observed with treatment of O. albiflora aerial part extract. Significant decrements were detected in the blood glucose levels as follows: 180.83±47.48 and 252.83±50.47mg/dL at 100 mg/kg and 200 mg/kg doses of O. albiflora, respectively, when compared to the isotonic saline...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Onobrychis; Antidiabetic activity; Alloxan; Rutin; Isoquercetin; Phytochemical analysis..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100504
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Antifungal activity of five species of Polygala BJM
Johann,Susana; Mendes,Beatriz G; Missau,Fabiana C; Resende,Maria A. de; Pizzolatti,Moacir G.
Crude extracts and fractions of five species of Polygala - P. campestris, P. cyparissias, P. paniculata, P. pulchella and P. sabulosa - were investigated for their in vitro antifungal activity against opportunistic Candida species, Cryptococcus gattii and Sporothrix schenckii with bioautographic and microdilution assays. In the bioautographic assays, the major extracts were active against the fungi tested. In the minimal concentration inhibitory (MIC) assay, the hexane extract of P. paniculata and EtOAc fraction of P. sabulosa showed the best antifungal activity, with MIC values of 60 and 30 µg/mL, respectively, against C. tropicalis, C. gattii and S. schenckii. The compounds isolated from P. sabulosa prenyloxycoumarin and 1,2,3,4,5,6-hexanehexol displayed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Polygalaceae; Polygala species; Antifungal activity; Rutin; Α-spinasterol.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000300027
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Antihypoxic, nephroprotective and antioxidant properties of hydro-alcoholic extract of loquat flowers ArchiMer
Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad; Moghaddam, Akbar Hajizadeh; Hellio, Claire; Ebrahimzadeh, Mohammad Ali.
Objectives: Loquat is well known Chinese medicinal herb with numerous traditional usages. The fact of the promising effect of loquat on different diseases is approved by a plethora of recent studies. Methods: In the present study antihypoxic, antioxidant and nephroprotective activity of hydro-alcoholic extract of Eriobotrya japonica flower was an investigated employing different in vivo and in vitro assay system. The chemical analysis of Eriobotrya japonica flowers, using atomic absorption spectroscopy, highlighted the presence of eight elements. Gallic acid, rutin and quercetin were determined by HPLC/DAD. Results: Results indicated that the hydro-alcoholic extract has a protective effect against hypoxia induced lethality in mice. Extract at doses of 200...
Tipo: Text Palavras-chave: Free radical; Eriobotrya japonica; Gentamicin; Rutin.
Ano: 2015 URL: https://archimer.ifremer.fr/doc/00299/40980/73190.pdf
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Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom BJMBR
Alves,N.T.Q.; Ximenes,R.M.; Jorge,R.J.B.; Silveira,J.A.M.; Santos,J.V.A.; Rodrigues,F.A.P.; Costa,P.H.S.; Xavier Jr.,F.A.F.; Evangelista,J.S.A.M.; Havt,A.; Soares,V.C.G.; Toyama,M.H.; Oliveira,A.N.A.; Araújo,R.M.; Alves,R.S.; Monteiro,H.S.A..
Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic activities were investigated in mice. Phytochemical analysis revealed the presence of saponins, flavonoids, and sugars, with rutin and saccharose being the major constituents of BFRE. Acute toxicity was determined and BFRE was nontoxic to mice. Phospholipase A2 and proteolytic activities induced by BjuV were inhibited in vitro by BFRE at all...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bredemeyera floribunda; Snakeroot; Snake venom; Rutin; Antihemorrhagic; Anti-edematogenic.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100608
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Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying BJPS
Pedrozo,Regiellen Cristina; Antônio,Emilli; Khalil,Najeh Maissar; Mainardes,Rubiana Mara.
Rutin is a flavonoid compound obtained from different vegetables and fruits; specifically, it is found in the seeds of buckwheat and in fruit peels, particularly citrus. It is also an important constituent of red wine. Rutin exhibits various biological properties including antiviral, vasoprotective, anti-inflammatory, and anticarcinogenic activities. However, its antioxidant activity is the most well studied. Despite the potential for in vitro applications, rutin presents low oral bioavailability that affects its biological activities. Nanoparticles composed of polymers, protein, or lipids are of great importance in the pharmaceutical and nutraceutical areas due to their physicochemical properties, which improve the pharmacokinetics of the drug which is...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nano spray drying; Rutin; Nanoparticles; Bovine serum albumin; Antioxidant.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100512
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Efeito de rutina no desenvolvimento ninfal do predador Podisus nigrispinus (Dallas) (Heteroptera: Pentatomidae). Repositório Alice
PIUBELLI, G. C.; HOFFMANN-CAMPO, C. B.; MOSCARDI, F.; MIYAKUBO, S. H.; TOLEDO, A. M..
bitstream/item/190641/1/ID-22636.pdf
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Entomologia; Rutin; Entomology.
Ano: 2003 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/465916
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Effect of rutin on the biology and physiology of Anticarsia gemmatalis from strains of susceptible and resistant to the AgMNPV. Repositório Alice
PIUBELLI, G. C.; HOFFMANN-CAMPO, C. B.; MOSCARDI, F.; OLIVEIRA, M. C. N. de.
Flavonoids in general have been related with plant protection against different sources of stress. Rutin (quercetin 3-O-rutinoside) is a flavonol identified in soybean resistant genotypes and it is known to play an important role on plant defenses against defoliating insects. Nevertheless, some authors have reported that rutin can also interfere with the nuclear polyhedrosis virus (NPV) infections. Experiments were carried out to evaluate the effect of rutin on two strains of Anticarsia gemmatalis, susceptible (S) and resistant (R) to the A. gemmatalis Multiple NPV (AgMNPV). Since eclosion, larvae from both populations were fed on a diet without (control) or with rutin (0.65% and 1.30%) addition. At the end of second instar, larvae were weighed and...
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Soja; Entomologia; Soybeans; Rutin; Entomology.
Ano: 2004 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/466746
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Effect of sprayed cis-jasmone on the flavonoid content, lipoxigenase activity, defoliation of soybean and on anticarsia gemmatalis gain of weigh. Repositório Alice
HOFFMANN-CAMPO, C. B.; FERNANDEZ, L. A.; GRA, J. P. da; MORAES, M. C. B.; BIRKETT, M. A.; OLIVEIRA, M. C. N. de; CAMPO, R. J..
bitstream/item/190529/1/ID-30046.pdf
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Lipoxigenase; Malonyl genistin; Acetyl genistin; Soja; Praga de planta; Variedade; Anticarsia Gemmatalis; Soybeans; Plant pests; Cultivars; Genistin; Rutin.
Ano: 2009 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/577369
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Effects of In-Ovo Rutin Injection to Fertile Japanese Quail (Coturnix Coturnix Japonica) Egg on Hatchability, Embryonic Death, Hatchling Weight, and Hatchling Liver Oxidative and Nitrosative Stress Rev. Bras. Ciênc. Avic.
Genc,M; Kandemir,FM; Coban,O.
ABSTRACT This study was conducted with the aim of investigating the effects of the antioxidant rutin injected in fertilized quail eggs on incubation parameters and some hatchling liver biochemical parameters. The study was carried out with 6 groups including a control group and 5 different doses of rutin, and it involved 720 fresh Japanese quail (Coturnix coturnix japonica) eggs. It was observed that rutin dose did not affect the early embryo mortality, whereas intermediate and late embryo mortality rates were higher in all groups given rutin in comparison to the control group. The mean hatchability of fertile eggs and total eggs for the control, 0.25 mg, 0.50 mg, 0.75 mg, 1 mg and 1.5 mg groups were calculated as 82.06, 82.23, 64.43, 68.84, 44.08, 22.95 %...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hatchability; In-ovo injection; Oxidative stress; Nitrosative stress; Rutin.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2019000100329
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Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats Biol. Res.
Hafez,Mohamed M; Al-Harbi,Naif O; Al-Hoshani,Ali Rashed; Al-hosaini,Khaled A; Al Shrari,Shakir D; Al Rejaie,Salim S; Sayed-Ahmed,Mohamed M; Al-Shabanah,Othman A.
BACKGROUND: Carbon tetrachloride (CCl4) induces hepatotoxicity in animal models, including the increased blood flow and cytokine accumulation that are characteristic of tissue inflammation. The present study investigates the hepato-protective effect of rutin on CCl4-induced hepatotoxicity in rats. RESULTS: Forty male Wistar rats were divided into four groups. Group I (control group) received 1 mL/kg of dimethyl sulfoxide intragastrically and 3 mL/kg olive oil intraperitoneally twice a week for 4 weeks. Group II received 70 mg/ kg rutin intragastrically. Groups III and IV received CCl4 (3 mL/kg, 30 % in olive oil) intraperitoneally twice a week for 4 weeks. Group IV received 70 mg/kg rutin intragastrically after 48 h of CCl4 treatment. Liver enzyme levels...
Tipo: Journal article Palavras-chave: Hepatotoxicity; Rutin; Inflammatory cytokine; MEK5; FADD; STAT3; JAK genes expression.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100030
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In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides L. BJM
Jesus,Roberta S.; Piana,Mariana; Freitas,Robson B.; Brum,Thiele F.; Alves,Camilla F.S.; Belke,Bianca V.; Mossmann,Natália Jank; Cruz,Ritiel C.; Santos,Roberto C.V.; Dalmolin,Tanise V.; Bianchini,Bianca V.; Campos,Marli M.A.; Bauermann,Liliane de Freitas.
Abstract The main objective of this study was to demonstrate the antimicrobial potential of the crude extract and fractions of Chenopodium ambrosioides L., popularly known as Santa-Maria herb, against microorganisms of clinical interest by the microdilution technique, and also to show the chromatographic profile of the phenolic compounds in the species. The Phytochemical screening revealed the presence of cardiotonic, anthraquinone, alkaloids, tannins and flavonoids. The analysis by HPLC-DAD revealed the presence of rutin in the crude extract (12.5 ± 0.20 mg/g), ethyl acetate (16.5 ± 0.37 mg/g) and n-butanol (8.85 ± 0.11 mg/g), whereas quercetin and chrysin were quantified in chloroform fraction (1.95 ± 0.04 and 1.04 ± 0.01 mg/g), respectively. The most...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amaranthaceae; Antimicrobial potential; Rutin; Quercetin; Chrysin.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200296
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Inibição de crescimento da lagarta-da-soja e efeitos pós-ingestivos de sua dieta enriquecida com diferentes concentrações de rutina e genistina. Repositório Alice
SALVADOR, M. C.; MIYAKUBO, S. H.; SILVA, S. H.; NEVES, M. C.; HOFFMANN-CAMPO, C. B..
Os flavonóides são as substâncias de defesa mais prováveis da soja e, dentre eles, o flavonol rutina (quercitina 3-0-rutinosidio) é reconhecido por desempenhar papel importante na proteção de plantas contra lepidópteros. Na fração mais ativa de extratos foliares da PI 227687 e PI 274454 identificou-se também a isoflavona genistina (genisteína 7-0-ß-D-glicosidio). Para avaliar a atividade biológica dessas substâncias sobre populações de A. gemmatalis, rutina O,25g (R1) e 0,50 g (R2), genistina 0,017g (G1) e O,034g (G2 e a mistura das duas [O,25g de R + O,O17g de G (R+G)) foram adicionadas à dieta artificial; dietas sem adição das substâncias foram consideradas testemunha. As lagartas foram criadas desde a eclosão em suas respectivas dietas e, na pré-muda,...
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Lagarta; Soja; Soybeans; Rutin; Genistin.
Ano: 2005 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/468725
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Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters Anais da ABC (AABC)
Kanashiro,Alexandre; Andrade,Daiani C.O.; Kabeya,Luciana M.; Turato,Walter M.; Faccioli,Lucia H.; Uyemura,Sérgio A.; Lucisano-Valim,Yara M..
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rutin; Golden Syrian hamster; Hypercholesterolemia; Atherosclerosis; Apoptosis; Dimorphandra mollis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009
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Post-ingestive effects of flavonoids in the midgut epithelium of Anticarsia gemmatalis (Hübner 1818) (Lepidoptera: Erebidae) larvae. Repositório Alice
CRUZ, N. A.; HOFFMANN-CAMPO, C. B.; LEVY, S. M.; FALLEIROS, A. M. F..
bitstream/item/189864/1/Cruz-p-185.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Lagarta; Soja; Praga de Planta; Morfologia Animal; Soybeans; Animal morphology; Rutin; Genistin.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1103179
Registros recuperados: 15
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