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	Provedor de dados BJMBR (6) BABT (1) Autor Abreu,G.R. (1) Atala,M.M. (1) Baldo,M.P. (1) Bissoli,N.S. (1) Borges,A.C.R. (1) Cabral,A.M. (1) Cardoso,L. (1) Cestari,I.A. (1) Consolim-Colombo,F.M. (1) Costa,Virginia Alice Vieira da (1) Dalle Lucca,J.J. (1) Dalle Lucca,S.L.D. (1) Dantas,E.M. (1) Dias,D.P.M. (1) Drager,L.F. (1) Fazan Jr.,R. (1) Gao,Feng (1) Hou,Zuoxu (1) Ihara,S.S.M. (1) Krieger,E.M. (1) Mais... Palavra-chave SHR (7) Cardiac hypertrophy (2) Hypertension (2) ACE inhibition (1) Aorta remodeling (1) Autoregressive model (1) Blood pressure (1) Captopril (1) Chemosensitive reflex (1) Diabetes (1) Enalapril (1) Estrogen (1) Exercise training (1) Fast Fourier transform (1) Heart rate variability (1) Insulin (1) Membrane potential (1) Mitochondria function (1) Oxidative stress (1) Pharmacological blockade (1) Mais... Tipo do documento Info:eu-repo/semantics/article (6) Info:eu-repo/semantics/other (1) Ano 2019 (1) 2010 (2) 2009 (1) 2008 (1) 2000 (2) País Brazil (7) Idioma Inglês (7)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 7 Primeira ... 1 ... Última Abnormal proliferative response of the carotid artery of spontaneously hypertensive rats after angioplasty may be related to the depolarized state of its smooth muscle cells BJMBR Dalle Lucca,S.L.D.; Dalle Lucca,J.J.; Borges,A.C.R.; Ihara,S.S.M.; Paiva,T.B.. Hypertension is one of the major precursors of atherosclerotic vascular disease, and vascular smooth muscle abnormal cell replication is a key feature of plaque formation. The present study was conducted to examine the relationship between hypertension and smooth muscle cell proliferation after balloon injury and to correlate neointima formation with resting membrane potential of uninjured smooth muscle cells, since it has been suggested that altered vascular function in hypertension may be related to the resetting of the resting membrane potential in spontaneously hypertensive rats (SHR). Neointima formation was induced by balloon injury to the carotid arteries of SHR and renovascular hypertensive rats (1K-1C), as well as in their normotensive controls,... Tipo: Info:eu-repo/semantics/article Palavras-chave: SHR; Renovascular hypertension; Restenosis; Smooth muscle cell; Membrane potential. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000800008 Biological response of spontaneously hypertensive rats to the streptozotocin administration BABT Costa,Virginia Alice Vieira da; Vianna,Lucia Marques. The sensitivity of adult spontaneously hypertensive rats (SHR) to the diabetogenic effect of streptozotocin (STZ) was studied. The animals were subdivided into three groups: control (citrate buffer), streptozotocin 40 mg/kg or 50 mg/kg, and general biologic parameters were analyzed, in addition to systolic blood pressure, blood glucose and insulin levels determinations. Both doses were able to induce hyperglycemia above 300 mg/dl; however, 50 mg/kg provoked a more pronounced physiological alterations in body weight, diuresis, water and food intake. There was no change on systolic blood pressure with either dose. Results suggested that SHRs did not need doses of streptozotocin above 40mg/kg in order to produce diabetes probably because this strain was much... Tipo: Info:eu-repo/semantics/article Palavras-chave: Streptozotocin; SHR; Diabetes; Blood pressure; Insulin. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000100006 Critical analysis of autoregressive and fast Fourier transform markers of cardiovascular variability in rats and humans BJMBR Silva,G.J.J.; Ushizima,M.R.; Lessa,P.S.; Cardoso,L.; Drager,L.F.; Atala,M.M.; Consolim-Colombo,F.M.; Lopes,H.F.; Cestari,I.A.; Krieger,J.E.; Krieger,E.M.. The autonomic nervous system plays an important role in physiological and pathological conditions, and has been extensively evaluated by parametric and non-parametric spectral analysis. To compare the results obtained with fast Fourier transform (FFT) and the autoregressive (AR) method, we performed a comprehensive comparative study using data from humans and rats during pharmacological blockade (in rats), a postural test (in humans), and in the hypertensive state (in both humans and rats). Although postural hypotension in humans induced an increase in normalized low-frequency (LFnu) of systolic blood pressure, the increase in the ratio was detected only by AR. In rats, AR and FFT analysis did not agree for LFnu and high frequency (HFnu) under basal... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fast Fourier transform; Autoregressive model; Hypertension; SHR; Pharmacological blockade; Tilt test. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000400012 Kinetics of cardiac and vascular remodeling by spontaneously hypertensive rats after discontinuation of long-term captopril treatment BJMBR Rocha,W.A.; Lunz,W.; Baldo,M.P.; Pimentel,E.B.; Dantas,E.M.; Rodrigues,S.L.; Mill,J.G.. Angiotensin-converting enzyme inhibitors reduce blood pressure and attenuate cardiac and vascular remodeling in hypertension. However, the kinetics of remodeling after discontinuation of the long-term use of these drugs are unknown. Our objective was to investigate the temporal changes occurring in blood pressure and vascular structure of spontaneously hypertensive rats (SHR). Captopril treatment was started in the pre-hypertensive state. Rats (4 weeks) were assigned to three groups: SHR-Cap (N = 51) treated with captopril (1 g/L) in drinking water from the 4th to the 14th week; SHR-C (N = 48) untreated SHR; Wistar (N = 47) control rats. Subgroups of animals were studied at 2, 4, and 8 weeks after discontinuation of captopril. Direct blood pressure was... Tipo: Info:eu-repo/semantics/article Palavras-chave: SHR; Cardiac hypertrophy; Aorta remodeling; ACE inhibition; Captopril. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400010 Moderate-intensity exercise allows enhanced protection against oxidative stress-induced cardiac dysfunction in spontaneously hypertensive rats BJMBR Mi,Chunjuan; Qin,Xinghua; Hou,Zuoxu; Gao,Feng. The progression of myocardial injury secondary to hypertension is a complex process related to a series of physiological and molecular factors including oxidative stress. This study aimed to investigate whether moderate-intensity exercise (MIE) could improve cardiac function and oxidative stress in spontaneously hypertensive rats (SHRs). Eight-week-old male SHRs and age-matched male Wistar-Kyoto rats were randomly assigned to exercise training (treadmill running at a speed of 20 m/min for 1 h continuously) or kept sedentary for 16 weeks. Cardiac function was monitored by polygraph; cardiac mitochondrial structure was observed by scanning electron microscope; tissue free radical production was measured using dihydroethidium staining. Expression levels of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; SHR; Oxidative stress; SIRT3/SOD2; Mitochondria function. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600603 Ovariectomy does not affect the cardiac sympathovagal balance of female SHR but estradiol does BJMBR Dias,D.P.M.; Oliveira,M.; Salgado,H.C.; Fazan Jr.,R.. The low incidence of cardiovascular diseases, including hypertension, in premenopausal women has led to the conclusion that ovarian hormones may have a protective effect on the cardiovascular system. We evaluated the effects of ovariectomy and/or estradiol on sympathovagal balance and heart rate variability (HRV) in female spontaneously hypertensive rats (SHR) with tachycardia and compared them to Wistar rats (12 weeks old; N = 8-12). Ovariectomy (OVX) and/or estradiol (10 µg/kg) did not affect basal arterial pressure in either rat strain, but estradiol increased basal heart rate (HR) in OVX SHR (454 ± 18 vs 377 ± 9 bpm). HR changes elicited by methylatropine and propranolol were used to evaluate the sympathovagal balance. Ovariectomy did not affect the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Estrogen; SHR; Heart rate variability; Hypertension; Sympathovagal balance. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000008 The cardiopulmonary reflexes of spontaneously hypertensive rats are normalized after regression of left ventricular hypertrophy and hypertension BJMBR Uggere,T.A.; Abreu,G.R.; Sampaio,K.N.; Cabral,A.M.; Bissoli,N.S.. Cardiopulmonary reflexes are activated via changes in cardiac filling pressure (volume-sensitive reflex) and chemical stimulation (chemosensitive reflex). The sensitivity of the cardiopulmonary reflexes to these stimuli is impaired in the spontaneously hypertensive rat (SHR) and other models of hypertension and is thought to be associated with cardiac hypertrophy. The present study investigated whether the sensitivity of the cardiopulmonary reflexes in SHR is restored when cardiac hypertrophy and hypertension are reduced by enalapril treatment. Untreated SHR and WKY rats were fed a normal diet. Another groups of rats were treated with enalapril (10 mg kg-1 day-1, mixed in the diet; SHRE or WKYE) for one month. After treatment, the volume-sensitive reflex... Tipo: Info:eu-repo/semantics/other Palavras-chave: Volume-sensitive reflex; Cardiac hypertrophy; Chemosensitive reflex; SHR; Enalapril. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500014 Registros recuperados: 7 Primeira ... 1 ... Última

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