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| Registros recuperados: 56 | |
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| Silva-Sena,Geralda Gillian; Camporez,Daniela; Santos,Lígia Ramos dos; Silva,Aline Sesana da; Sagrillo Pimassoni,Lúcia Helena; Tieppo,Alessandra; Pimentel Batitucci,Maria do Carmo; Morelato,Renato Lírio; Paula,Flavia de. |
| Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lifespan; SNPs; Environmental factors; Oxidative stress; Genomic damage. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300386 |
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| Marrube,G; Soria,LA; Rozen,FMB; Corva,PM; Schor,A; Melucci,LM; Villarreal,EL; Mezzadra,CA; Miquel,MC. |
| La enzima Acido Graso Sintasa (FASN) cataliza la síntesis de los ácidos grasos en la célula y presenta un rol fundamental en el metabolismo de los lípidos. Con el propósito de analizar el efecto de dos polimorfismos de un solo nucleótido (SNPs) en el gen FASN (G>C en el exón 1 y A>G en el exón 34) se analizaron los siguientes caracteres productivos: Peso Vivo Final, Ganancia Diaria de Peso Vivo, Tasa Mensual de Engrasamiento, Grasa Riñonada, Porcentaje de Grasa Riñonada, Rendimiento de la Canal, Porcentaje de Grasa Intramuscular, en novillos de razas Angus (n = 20) y Brangus (n = 60). Se desarrollaron técnicas de mismatch PCR para determinar los genotipos de ambos SNPs. El análisis estadístico se realizó mediante un modelo de efectos fijos... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bovinos para carne; Calidad de la carne; Gen FASN; SNPs. |
| Ano: 2010 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332010000100005 |
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| LIMA, A. O. de; OLIVEIRA, P. S. N. de; TIZIOTO, P. C.; AFONSO, J.; SOMAVILLA, A. L.; DINIZ, W. J. da S.; SILVA, J. V. da; ROCHA, M. I. P.; MUDADU, M. de A.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
| 2016 |
| Tipo: Resumo em anais de congresso (ALICE) |
Palavras-chave: Haplótipo; SNPs; Gado de corte; Gado nelore; Haplotypes; Nellore. |
| Ano: 2016 |
URL: http://www.alice.cnptia.embrapa.br/handle/doc/1056239 |
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| Almeida,Sabrina Esteves Matos; Almeida,Erik Amazonas de; Terra,Gustavo; Neves,Jairo Pereira; Gonçalves,Paulo Bayard Dias; Weimer,Tania de Azevedo. |
| Three short tandem repeats (STRs), BMS1074, BM1500, IDVGA-51, and three single nucleotide polymorphisms (SNPs), LEPSau3AI (A/B), LEPSau3AI (+/-) and LEPKpn2I linked to the LEP gene were investigated to verify associations with productive performance in postpartum cows of two beef cattle breeds, Aberdeen Angus (AA, n=98) and Charolais (C, n=83). After polymerase chain reaction, STRs were analyzed by vertical electrophoresis and SNPs in agarose gel after endonucleases cleavage. In AA herd 79% of BMS1074*151 carriers had a lower average daily weight gain (ADG) when compared with the population mean daily weight gain (103g), while 62% of BMS1074*151 non-carriers presented a higher ADG (P<0.01); AA animals with at least one BMS1074*151 allele showed a ADG... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leptin; STRs; SNPs; Beef cattle; Weight gain; Post-partum. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000100033 |
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| Wang,Jinjin; Zhang,Jianfeng; Li,Linlin; Wang,Yan; Wang,Qian; Zhai,Yujia; You,Haifei; Hu,Dongsheng. |
| Our objective was to evaluate the association of rs12255372 in theTCF7L2 gene with type 2 diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature about the effect of rs12255372 on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, and then performed a meta-analysis of all the studies in order to evaluate the association between rs12255372 and T2DM. A total of 33 articles including 42 studies (with 34,076 cases and 36,192 controls) were confirmed to be eligible and were included in the final meta-analysis: 6 studies conducted on Europeans, 14 on Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans. Overall, the effect size was as follows: for the variant allele... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Type 2 diabetes mellitus; Rs12255372; SNPs; Meta-analysis. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400382 |
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| Shaheen,Tayyaba; Zafar,Yusuf; Mehboob-ur-Rahman,. |
| Exploring genetic variation in Gossypium arboreum L. germplasm is useful as it contains many important genes conferring resistance to different stresses. In limited earlier studies, low level of genetic diversity was found by using conventional DNA marker systems which may impede future genome mapping studies. In the present investigation, we explored the extent of Single Nucleotide Polymorphisms (SNP) among 30 conserved regions of Expressed Sequence Tags (EST) of low copy genes between two genotypes of G. arboreum. A total of 27 SNPs including 21 substitutions and 6 Insertions and deletions (Indels) in 7804 bp were found between these genotypes with a frequency of one SNP per 371 bp and one Indel after every 1300 bp. Out of these SNPs, 52% were... |
| Tipo: Journal article |
Palavras-chave: Conserved regions; Gossypium arboretum; SNPs. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582010000500003 |
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| Sauvage, Christopher; Lapegue, Sylvie; Bierne, Nicolas; Boudry, Pierre. |
| Summer mortalities of the Pacific cupped oyster Crassostrea gigas have been described in the literature for decades. One solution to overcome this problem would be to select animals more tolerant to summer mortalities, as this trait was shown to be highly heritable (Degrémont, 2003). The identification of markers associated to the resistance would allow to better understand this complex phenomenon and, eventually to establish markers assisted selection. Recently, two moderately dense genetic linkage maps have been established in the Pacific oyster based on microsatellites and AFLP markers (Hubert and Hedgecock, 2004; Li and Guo, 2004). In this context, the development and mapping of SNPs will increase the density of the linkage map and consequently the... |
| Tipo: Text |
Palavras-chave: QTLs analyses; Summer mortaliy; Genetic; SNPs; Crassostrea gigas; Oyster. |
| Ano: 2006 |
URL: http://archimer.ifremer.fr/doc/2006/acte-3351.pdf |
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| IVAMOTO, S. T.; POT, D.; LANNES, S. D.; DOMINGUES, D. S.; VIEIRA, L. G. E.; PEREIRA, L. F. P.. |
| Os ácidos clorogênicos (CGAs) são compostos químicos importantes de Coffea spp. para a qualidade da bebida, pois eles interferem na adstringência e podem alterar o aroma e sabor da bebida. Aproximadamente 310.000 ESTs de Coffea estão disponíveis e possibilitam o acesso à variabilidade nucleotídica da planta e o desenvolvimento de marcadores moleculares ligados à qualidade da bebida para as principais enzimas da via de biossíntese dos CGAs: PAL, C4H, 4CL, CQT e C3?H. Neste trabalho foram detectados polimorfismos dos tipos SNP, INDEL ou SSR dentro das sequências nucleotídidicas disponíveis no Projeto Genoma Café e no NCBI. As sequências de ESTs de CGAs foram clusterizadas pelo programa Codon Code Aligner, assim como a detecção de polimorfismos e validação... |
| Tipo: Artigo em periódico indexado (ALICE) |
Palavras-chave: SNPs; SSRs; ESTs; CGAs; Polimorfismo; Marcador molecular. |
| Ano: 2013 |
URL: http://www.alice.cnptia.embrapa.br/handle/doc/986384 |
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| Registros recuperados: 56 | |
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