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A meta-analysis of efficacy and safety of doripenem for treating bacterial infections BJID
Qu,Xiao-Yu; Hu,Ting-Ting; Zhou,Wei.
Objective: The aim of this article is to compare the efficacy and safety of doripenem for bacterial infections. Methods: We included six randomized clinical trials identified from PubMed and Embase up to July 31, 2014. The included trials compared efficacy and safety of doripenem for complicated intra-abdominal infections, complicated urinary tract infection, nosocomial pneumonia, and acute biliary tract infection. The meta-analysis was carried on by the statistical software of Review Manager, version 5.2. Results: Compared with empirical antimicrobial agents on overall treatment efficacy, doripenem was associated with similar clinical and microbiological treatment success rates (for the clinical evaluable population, odds ratio [OR] = 1.26, 95% confidence...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Doripenem Meta-analysis Efficacy; Safety; Infection.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200156
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Accidents involving specialized aircraft in agriculture aerial spraying Ciência Rural
Ravelli,Marcelo Boamorte; Zerbato,Cristiano; Oliveira,Mailson Freire de; Corrêa,Rafael de Graff.
ABSTRACT: The great challenge for the practice of agricultural aviation has been to avoid accidents. Although, there are technological progress and high resources for safety, accidents continue to occur. The objective of this research was to analyze the influence and occurrence of factors in agricultural aviation accidents in Brazil recently. Based on research and technical - scientific papers written by researchers and aviation authorities, recommendations directed towards reducing the risks associated with this aircraft modality are assessed. The main factors responsible for accidents are normally operational errors and maneuvers that cause flight collisions, engine failures and altitude loss. Professional awareness and qualification converge towards the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Specialized aviation; Agricultural aviation; Danger; Safety; Training.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000700356
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Acute Toxicity and Cytotoxicity Effect of Ethanolic Extract of Spondias tuberosa Arruda Bark: Hematological, Biochemical and Histopathological Evaluation Anais da ABC (AABC)
BARBOSA,HUMBERTO M.; NASCIMENTO,JAILSON N. DO; ARAÚJO,THIAGO A.S.; DUARTE,FILIPE S.; ALBUQUERQUE,ULYSSES P.; VIEIRA,JEYMESSON R.C.; SANTANA,EDSON R.B. DE; YARA,RICARDO; LIMA,CLÁUDIA S.A.; GOMES,DAYANE A.; LIRA,EDUARDO C..
ABSTRACT Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501993
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ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia BJMBR
Noël,F.; Nascimento-Viana,J.B.; Romeiro,L.A.S.; Silva,R.O.; Lemes,L.F.N.; Oliveira,A.S.; Giorno,T.B.S.; Fernandes,P.D.; Silva,C.L.M..
This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME) properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound comprised the evaluation of its in vitro properties, including plasma, microsomal and hepatocytes stability, cytochrome P450 metabolism and inhibition, plasma protein binding, and permeability using MDCK-MDR1 cells. De-risking and preliminary safety pharmacology assays were performed through screening of 44 off-target receptors and in vivo tests in mice (rota-rod and single dose toxicity). LDT5 is stable in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Benign prostatic hyperplasia; ADME; Safety; Permeability; CYP; Preclinical development.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001200603
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Are Standards Always Protectionist? AgEcon
Marette, Stephan; Beghin, John C..
We analyze the effects of a domestic standard that reduces an externality associated with the consumption of the good targeted by the standard, using a model in which foreign and domestic producers compete in the domestic good market. Producers can reduce expected damage associated with the externality by incurring a cost that varies by source of origin. Despite potential protectionism, the standard is useful in correcting the consumption externality in the domestic country. Protectionism occurs when the welfare-maximizing domestic standard is higher than the international standard maximizing welfare inclusive of foreign profits. The standard is actually anti-protectionist when foreign producers are much more efficient at addressing the externality than...
Tipo: Working or Discussion Paper Palavras-chave: Externality; Nontariff barriers; Protectionism; Safety; Standard; Tariff equivalent; International Relations/Trade.
Ano: 2007 URL: http://purl.umn.edu/10007
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Biochemical characteristics of composite flours: influence of fermentation Ciênc. Tecnol. Aliment.
Digbeu,Dogore Yolande; Due,Ahipo Edmond; Dabonne,Soumaila.
The purpose of this study was to introduce yam in the development of two new composite flours containing soy and cassava. Two composite flours were obtained after fermentation of yam, soybean, and cassava in respectively 60, 30, and 10% proportions. Two varieties of yam were used: Dioscorea alata (variety "Bete bete") and Dioscorea cayenensis (variety "Lokpa"). Proximate composition, mineral content, some anti-nutritional factors (oxalates, phenols), microbiological quality, and α-amylase digestibility were determined for the fermented and unfermented composite flours. The results indicated that for the composite flours made of D. alata and D. cayenensis, fermentation increased ash and titrable acidity. Carbohydrates, pH, and energy decreased. Crude fat...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Infant food; Tropical tuber; Nutritional analysis; Safety.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612013000400001
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Calidad del chile poblano, oportunidad de comercio para productores de San Matías Tlalancaleca y San Rafael Tlanalapa, Puebla. Colegio de Postgraduados
Cruz Vargas, Alejandro.
En la Sierra Nevada del estado de Puebla, el cultivo de chile poblano (capsicum annuum) presenta un descenso en superficie sembrada, debido a precios bajos que resultan de la competencia con el chile proveniente de otros estados del país, y bajos rendimientos. El objetivo de este trabajo consistió en determinar si en la producción del picante la adopción de criterios de calidad alimentaria representa una oportunidad de mercado, y de aumento de ganancias, considerando a la industría restaurantera como nicho de mercado durante la temporada de chiles en nogada. Para ello, se realizó un estudio de caso con aplicación de entrevistas estructuradas a productores de San Matías Tlalancaleca, San Rafael Tlanalapa y a restauranteros del centro histórico de la capital...
Palavras-chave: Autenticidad; Chile poblano; Comercialización; Inocuidad; Rentabilidad; Authenticity; Marketing; Profitability; Safety; Estrategias para el Desarrollo Agrícola Regional; EDAR; Maestría.
Ano: 2013 URL: http://hdl.handle.net/10521/1981
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Comparison between the efficiency of two bioindicators for determining surface water quality in an urban environment - doi: 10.4025/actascibiolsci.v33i3.7725 Biological Sciences
Oliveira-Filho, Eduardo Cyrino; Embrapa Cerrados; Ramos, Marianni Gonçalves; Centro Universitário de Brasília - UniCEUB; Freire, Ingrid Souza; Centro Universitário de Brasília - UniCEUB; Muniz, Daphne Heloisa de Freitas; Embrapa Cerrados.
This study evaluated the efficiency of two bioindicators, fecal coliforms and ecotoxicity tests, set out in CONAMA Resolution 274/00 and CONAMA Resolution 357/05, in assessment of water quality. For this study, Lake Paranoá, Federal District of Brazil, was chosen, since it is a water body directly contaminated by effluents from a sewage treatment plant. Four sampling points were chosen in accordance with the map of recreational water quality published weekly by CAESB/DF, after analysis of fecal coliforms. Samples from these points were collected for 6 months and tested on Danio rerio fish (acute toxicity) and on the microcrustacean Ceriodaphnia dubia (acute and chronic toxicity), besides measuring chemical and physico-chemical parameters. The data obtained...
Palavras-chave: 2.00.00.00-6 water quality; Ecotoxicity tests; Fecal coliforms; Paranoá lake; Recreational water; Safety 2.00.00.00-6 water quality; Ecotoxicity tests; Fecal coliforms; Paranoá lake; Recreational water; Safety.
Ano: 2011 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/7725
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Consumer preferences and demand for livestock products in urban Bangladesh AgEcon
Islam, S.M. Fakhrul; Jabbar, Mohammad A..
Also available in the ILRI Repository on Livestock Research at http://hdl.handle.net/10568/3009
Tipo: Report Palavras-chave: Demand; Quality; Safety; Livestock products; Bangladesh; Consumer/Household Economics; Livestock Production/Industries.
Ano: 2010 URL: http://purl.umn.edu/97972
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Demand for livestock products in developing countries with a focus on quality and safety attributes: Evidence from case studies AgEcon
The case studies and the synthesis papers were presented at a mini-symposium at the International Association of Agricultural Economists conference held in Beijing, Peoples Republic of China, on 18–24 August 2009.
Tipo: Report Palavras-chave: Demand; Livestock products; Quality; Safety; Developing countries; Consumer/Household Economics; Livestock Production/Industries.
Ano: 2010 URL: http://purl.umn.edu/97973
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Disease Outbreaks and Agricultural Trade: The Case of Potatoes AgEcon
Clark, J. Stephen; Thibodeau, David R.; Grant, K. Gary; Prochazkova, Katerina.
This study analyzed the impact of PVYn and potato wart disease outbreaks in PEI on the potato industry. These disease outbreaks resulted in the loss of the US seed export market to PEI producers. The effects of the disease outbreaks were mitigated through value-added processing. Price premiums for processed potatoes allowed PEI potato producers to abandon seed exports without incurring losses. Evidence is presented to suggest that other countries have also used this approach when export restrictions were placed on domestic agricultural industries. Policy response to the two disease outbreaks include: i) development of a zones policy that helped to reopen markets into the US; and ii) financial compensation to producers above the minimum levels required...
Tipo: Working or Discussion Paper Palavras-chave: Disease; Trade; Potatoes; Canada; Food; Safety; Agricultural and Food Policy; International Development; International Relations/Trade.
Ano: 2008 URL: http://purl.umn.edu/43464
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Does Social Capital Create Trust? Evidence from a Community of Entrepreneurs AgEcon
Sabatini, Fabio.
Which kind of social capital fosters the diffusion of development-oriented trust? This paper carries out an empirical investigation into the causal relationships connecting four types of social capital (i.e. bonding, bridging, linking, and corporate), and different forms of trust (knowledge-based trust, social trust, trust towards public services and political institutions), in a community of entrepreneurs located in the Italian industrial district of the Tuscia. Our results suggest that the main factors fostering the diffusion of social trust among entrepreneurs are the perception that the local community is a safe place, and the establishment of corporate ties through professional associations. Trust in people is positively and significantly correlated...
Tipo: Working or Discussion Paper Palavras-chave: Trust; Social capital; Safety; Professional associations; Entrepreneurship; Corporate ties; Group and Interpersonal Processes; Social Perception and Cognition; Institutional and Behavioral Economics; J24; O15; Z13.
Ano: 2009 URL: http://purl.umn.edu/52340
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Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents) BJMBR
Calixto,J.B..
This review highlights the current advances in knowledge about the safety, efficacy, quality control, marketing and regulatory aspects of botanical medicines. Phytotherapeutic agents are standardized herbal preparations consisting of complex mixtures of one or more plants which contain as active ingredients plant parts or plant material in the crude or processed state. A marked growth in the worldwide phytotherapeutic market has occurred over the last 15 years. For the European and USA markets alone, this will reach about $7 billion and $5 billion per annum, respectively, in 1999, and has thus attracted the interest of most large pharmaceutical companies. Insufficient data exist for most plants to guarantee their quality, efficacy and safety. The idea that...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Herbal medicine; Efficacy; Safety; Quality control; Market; Regulatory guidelines.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200004
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Eugenol como anestésico para a tilápia-do-nilo. Repositório Alice
VIDAL, L.V.O.; ALBINATI, R.C.B.; ALBINATI, A.C.L.; LIRA, A.D. de; ALMEIDA, T.R. de; SANTOS, G.B..
O objetivo deste trabalho foi avaliar o eugenol como anestésico para a tilápia-do-nilo. Para a concentração ideal, foram avaliados seis tratamentos (50, 75, 100, 150, 200 e 250 mg L-1), com dez peixes por tratamento, anestesiados individualmente, acompanhados durante a indução e recuperação. A toxicidade foi estimada pela submissão de 210 peixes a 7 concentrações de eugenol (50, 75, 100, 150, 200, 250, 300 mg L-1), durante 600 s e, para a margem de segurança, 120 peixes foram submetidos a 75 mg L-1 durante cinco intervalos de tempo (600, 1.200, 1.800 e 2.400 s). As concentrações eficientes foram 50 e 75 mg L-1. Os valores de toxicidade letal (CL), aos 600 s, foram: CL01, 81,97 mg L-1; CL50, 184,26 mg L-1; e CL99, 286,55 mg L-1; e os tempos de concentrações...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Oreochromis niloticus; Anestesia; Custo; Segurança; Anesthesia; Cost; Safety.
Ano: 2008 URL: http://www.alice.cnptia.embrapa.br/handle/doc/122153
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Food safety challenges associated with traditional foods of Turkey Ciênc. Tecnol. Aliment.
CAGRI-MEHMETOGLU,Arzu.
Abstract Consumer food safety concerns are continually increasing in Turkey, with consumer demand for safer foods becoming an important challenge for the industry. Most traditional foods in Turkey are produced under different requirements, and food safety risk management and risk assessment are conducted primarily by the government. Based on risk assessment, safety regulations and standards for traditional foods (e.g. Turkish white cheese, doner, helva) have been established. In this paper, safety concerns surrounding the commercialization of traditional Turkish foods and related studies to identify and minimize potential hazards are discussed along with pathogen contamination in raw meat balls and aflatoxin in helva and white cheese. Based on this...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Traditional foods; Safety; Risk assessment; Turkey.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612018000100001
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Immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine: a Phase III, open-label study of adults in Brazil BJID
Zerbini,Cristiano A.F.; Ribeiro dos Santos,Rodrigo; Jose Nunes,Maria; Soni,Jyoti; Li,Ping; Jain,Varsha K.; Ofori-Anyinam,Opokua.
Abstract The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines.In this Phase III, open-label study, we assessed the immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine (Fluarix™ Tetra) in Brazilian adults (NCT02369341). The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Quadrivalent; Influenza; Vaccine; Immunogenicity; Safety; Brazil; Adults.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100063
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In vivo assessment of possible probiotic properties of Zymomonas mobilis in a Wistar rat model Electron. J. Biotechnol.
Azerêdo,Geíza Alves de; Stamford,Tânia Lúcia Montenegro; Souza,Evandro Leite de; Veras,Flávio Fonseca; Almeida,Edvaldo Rodrigues de; Araújo,Janete Magali de.
In recent years the incorporation of probiotic bacteria into foods has received increasing scientific interest for health promotion and disease prevention. The safety and probiotic properties of Zymomonas mobilis CP4 (UFPEDA-202) was studied in a Wistar rat model fed the 10(9) colony forming units (cfu)/mL-1 of the assayed strain for 30 days. No abnormal clinical signs were noted in the group receiving viable cells of Z. mobilis and water (control) during the period of the experiment. There were no significant difference (p > 0.05) in feed intake and weight gain among mice fed the Z. mobilis in comparison to the control group. No bacteria were found in blood, liver and spleen of any animals. Mice receiving Z. mobilis showed significantly differences (p...
Tipo: Journal article Palavras-chave: Health benefit; Safety; Zymomonas mobilis.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582010000200003
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La certificación de la calidad del producto, una alternativa de competitividad y negociación para el sector agroalimentario. Colegio de Postgraduados
Palacios Bautista, Elías.
La eliminación paulatina de los aranceles en la comercialización de los productos agroalimentarios, dio origen a nuevas disposiciones y a la utilización de las medidas no arancelarias (MNA), conocidas como obstáculos técnicos al comercio (OTC), es decir, las medidas sanitarias y fitosanitarias que restringen la importación y exportación de los productos que no cumplen con dichas regulaciones. Los OTC, responden a objetivos de política pública tales como: asegurar la salud, la seguridad y el bienestar de los consumidores, pero también pueden ser aplicados de manera tal que obstaculicen el comercio. El utilizar los OTC, involucra conceptos como calidad, inocuidad y certificación de productos, cuyo objetivo es evitar el brote de las Enfermedades Transmitidas...
Palavras-chave: Obstáculos técnicos al comercio; Medidas no arancelarias; Enfermedades transmitidas por los alimentos; Calidad; Inocuidad; Certificación; Estándares de certificación; Technical barriers to trade; Non-tariff measures; Foodborne diseases; Quality; Safety; Certification; Standard Certification; Economía; Maestría.
Ano: 2014 URL: http://hdl.handle.net/10521/2245
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La Mer : hommes - richesses - enjeux ArchiMer
Ifremer - Ena, -.
Chapters in Volume 1: - Law of the sea and international straits - Trends in the French merchant fleet - International shipping - Safety and rescue at sea, the case of yachting - Marine research and economic development - The respective roles played at sea by the state and local authorities - Social trends in populations linked to the sea: commercial seafarers - Future perspectives for marine leisure activities - French ports, outlook for the year 2000 Chapters in Volume 2: - European organisation in terms of seafood - The role of the sea in the development of the DOM/TOM (French overseas départements and territories) - France's international policy and naval and maritime resources - Naval strategies of the major powers -...
Tipo: Text Palavras-chave: Geopolitics; Seafood; Technologies; Scientific research; Marine leisure activities; Ports; Merchant fleet; Safety; Shipping; International policy; Europe; Economics; Politics; France; Sea; Ocean Mondial; Essai In Situ; Technologie; Recherche Scientifique; Port; Sauvetage; Plaisance; Securite; Transport Maritime; Commerce Maritime; Flotte; Droit De La Mer; Politique; Economie; Milieu Marin.
Ano: 1988 URL: http://archimer.ifremer.fr/doc/1988/rapport-1027.pdf
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Low- and No- Calorie Sweeteners (LNCS): critical evaluation of their safety and health risks Ciênc. Tecnol. Aliment.
MALULY,Hellen Dea Barros; JOHNSTON,Craig; GIGLIO,Norberto Damián; SCHREINER,Ligia Lindner; ROBERTS,Ashley; ABEGAZ,Eyassu Getachew.
Abstract The increase of the prevalence of type-2 diabetes as a consequence of overweight and obesity has stimulated public health authorities worldwide to develop strategies for its risk management and prevention. Among them, a reduction on the content of sugar in sugar-sweetened foods and beverages has been suggested, which led the food industry to replace partially sucrose with food additives, such as low- and no-calorie sweeteners (LNCS). As a consequence, there has been an increase of their consumption, which has made regulatory agencies to evaluate their exposure and possible consequences. At the same time, speculations about adverse effects, such as carcinogenicity, preterm delivery and metabolic changes involving appetite, weight increase and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sweeteners; Safety; Regulation; Metabolism; Cancer.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000100001
Registros recuperados: 44
Primeira ... 123 ... Última
 

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