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Registros recuperados: 42 | |
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Qu,Xiao-Yu; Hu,Ting-Ting; Zhou,Wei. |
Objective: The aim of this article is to compare the efficacy and safety of doripenem for bacterial infections. Methods: We included six randomized clinical trials identified from PubMed and Embase up to July 31, 2014. The included trials compared efficacy and safety of doripenem for complicated intra-abdominal infections, complicated urinary tract infection, nosocomial pneumonia, and acute biliary tract infection. The meta-analysis was carried on by the statistical software of Review Manager, version 5.2. Results: Compared with empirical antimicrobial agents on overall treatment efficacy, doripenem was associated with similar clinical and microbiological treatment success rates (for the clinical evaluable population, odds ratio [OR] = 1.26, 95% confidence... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Doripenem Meta-analysis Efficacy; Safety; Infection. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200156 |
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BARBOSA,HUMBERTO M.; NASCIMENTO,JAILSON N. DO; ARAÚJO,THIAGO A.S.; DUARTE,FILIPE S.; ALBUQUERQUE,ULYSSES P.; VIEIRA,JEYMESSON R.C.; SANTANA,EDSON R.B. DE; YARA,RICARDO; LIMA,CLÁUDIA S.A.; GOMES,DAYANE A.; LIRA,EDUARDO C.. |
ABSTRACT Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology. |
Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501993 |
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Noël,F.; Nascimento-Viana,J.B.; Romeiro,L.A.S.; Silva,R.O.; Lemes,L.F.N.; Oliveira,A.S.; Giorno,T.B.S.; Fernandes,P.D.; Silva,C.L.M.. |
This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME) properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound comprised the evaluation of its in vitro properties, including plasma, microsomal and hepatocytes stability, cytochrome P450 metabolism and inhibition, plasma protein binding, and permeability using MDCK-MDR1 cells. De-risking and preliminary safety pharmacology assays were performed through screening of 44 off-target receptors and in vivo tests in mice (rota-rod and single dose toxicity). LDT5 is stable in... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Benign prostatic hyperplasia; ADME; Safety; Permeability; CYP; Preclinical development. |
Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001200603 |
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Marette, Stephan; Beghin, John C.. |
We analyze the effects of a domestic standard that reduces an externality associated with the consumption of the good targeted by the standard, using a model in which foreign and domestic producers compete in the domestic good market. Producers can reduce expected damage associated with the externality by incurring a cost that varies by source of origin. Despite potential protectionism, the standard is useful in correcting the consumption externality in the domestic country. Protectionism occurs when the welfare-maximizing domestic standard is higher than the international standard maximizing welfare inclusive of foreign profits. The standard is actually anti-protectionist when foreign producers are much more efficient at addressing the externality than... |
Tipo: Working or Discussion Paper |
Palavras-chave: Externality; Nontariff barriers; Protectionism; Safety; Standard; Tariff equivalent; International Relations/Trade. |
Ano: 2007 |
URL: http://purl.umn.edu/10007 |
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Digbeu,Dogore Yolande; Due,Ahipo Edmond; Dabonne,Soumaila. |
The purpose of this study was to introduce yam in the development of two new composite flours containing soy and cassava. Two composite flours were obtained after fermentation of yam, soybean, and cassava in respectively 60, 30, and 10% proportions. Two varieties of yam were used: Dioscorea alata (variety "Bete bete") and Dioscorea cayenensis (variety "Lokpa"). Proximate composition, mineral content, some anti-nutritional factors (oxalates, phenols), microbiological quality, and α-amylase digestibility were determined for the fermented and unfermented composite flours. The results indicated that for the composite flours made of D. alata and D. cayenensis, fermentation increased ash and titrable acidity. Carbohydrates, pH, and energy decreased. Crude fat... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Infant food; Tropical tuber; Nutritional analysis; Safety. |
Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612013000400001 |
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Oliveira-Filho, Eduardo Cyrino; Embrapa Cerrados; Ramos, Marianni Gonçalves; Centro Universitário de Brasília - UniCEUB; Freire, Ingrid Souza; Centro Universitário de Brasília - UniCEUB; Muniz, Daphne Heloisa de Freitas; Embrapa Cerrados. |
This study evaluated the efficiency of two bioindicators, fecal coliforms and ecotoxicity tests, set out in CONAMA Resolution 274/00 and CONAMA Resolution 357/05, in assessment of water quality. For this study, Lake Paranoá, Federal District of Brazil, was chosen, since it is a water body directly contaminated by effluents from a sewage treatment plant. Four sampling points were chosen in accordance with the map of recreational water quality published weekly by CAESB/DF, after analysis of fecal coliforms. Samples from these points were collected for 6 months and tested on Danio rerio fish (acute toxicity) and on the microcrustacean Ceriodaphnia dubia (acute and chronic toxicity), besides measuring chemical and physico-chemical parameters. The data obtained... |
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Palavras-chave: 2.00.00.00-6 water quality; Ecotoxicity tests; Fecal coliforms; Paranoá lake; Recreational water; Safety 2.00.00.00-6 water quality; Ecotoxicity tests; Fecal coliforms; Paranoá lake; Recreational water; Safety. |
Ano: 2011 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/7725 |
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Calixto,J.B.. |
This review highlights the current advances in knowledge about the safety, efficacy, quality control, marketing and regulatory aspects of botanical medicines. Phytotherapeutic agents are standardized herbal preparations consisting of complex mixtures of one or more plants which contain as active ingredients plant parts or plant material in the crude or processed state. A marked growth in the worldwide phytotherapeutic market has occurred over the last 15 years. For the European and USA markets alone, this will reach about $7 billion and $5 billion per annum, respectively, in 1999, and has thus attracted the interest of most large pharmaceutical companies. Insufficient data exist for most plants to guarantee their quality, efficacy and safety. The idea that... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Herbal medicine; Efficacy; Safety; Quality control; Market; Regulatory guidelines. |
Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200004 |
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CAGRI-MEHMETOGLU,Arzu. |
Abstract Consumer food safety concerns are continually increasing in Turkey, with consumer demand for safer foods becoming an important challenge for the industry. Most traditional foods in Turkey are produced under different requirements, and food safety risk management and risk assessment are conducted primarily by the government. Based on risk assessment, safety regulations and standards for traditional foods (e.g. Turkish white cheese, doner, helva) have been established. In this paper, safety concerns surrounding the commercialization of traditional Turkish foods and related studies to identify and minimize potential hazards are discussed along with pathogen contamination in raw meat balls and aflatoxin in helva and white cheese. Based on this... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Traditional foods; Safety; Risk assessment; Turkey. |
Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612018000100001 |
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Zerbini,Cristiano A.F.; Ribeiro dos Santos,Rodrigo; Jose Nunes,Maria; Soni,Jyoti; Li,Ping; Jain,Varsha K.; Ofori-Anyinam,Opokua. |
Abstract The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines.In this Phase III, open-label study, we assessed the immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine (Fluarix™ Tetra) in Brazilian adults (NCT02369341). The... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quadrivalent; Influenza; Vaccine; Immunogenicity; Safety; Brazil; Adults. |
Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100063 |
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MACHADO, T. F.; GARRUTI, D. dos S.; SILVEIRA, M. R. S. da; VARELA, M. de S.; JESUS FILHO, C. A. de. |
O risco de subprodutos indesejáveis ​​da desinfecção com cloro em indústrias de produtos minimamente processados, juntamente com sua eficácia limitada, levou à busca de agentes alternativos. O objetivo deste estudo foi avaliar a eficácia dos óleos essenciais de capim-limão e alecrim-pimenta no controle da microflora natural de cenoura minimamente processada e, ao mesmo tempo, considerar seu impacto nas propriedades organolépticas do produto. Contudo, o uso de óleos essenciais de capim-limão e alecrim-pimenta resultou em cenouras minimamente processadas de baixa aceitabilidade, não sendo um tratamento recomendado nas concentrações testadas. |
Tipo: Folhetos |
Palavras-chave: Quality; Safety; Disinfection in fresh-cut industries; Daucus Carota; Cenoura; Qualidade; Segurança Alimentar; Daucus carota subsp. sativus. |
Ano: 2020 |
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1125690 |
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Palacios Bautista, Elías. |
La eliminación paulatina de los aranceles en la comercialización de los productos agroalimentarios, dio origen a nuevas disposiciones y a la utilización de las medidas no arancelarias (MNA), conocidas como obstáculos técnicos al comercio (OTC), es decir, las medidas sanitarias y fitosanitarias que restringen la importación y exportación de los productos que no cumplen con dichas regulaciones. Los OTC, responden a objetivos de política pública tales como: asegurar la salud, la seguridad y el bienestar de los consumidores, pero también pueden ser aplicados de manera tal que obstaculicen el comercio. El utilizar los OTC, involucra conceptos como calidad, inocuidad y certificación de productos, cuyo objetivo es evitar el brote de las Enfermedades Transmitidas... |
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Palavras-chave: Obstáculos técnicos al comercio; Medidas no arancelarias; Enfermedades transmitidas por los alimentos; Calidad; Inocuidad; Certificación; Estándares de certificación; Technical barriers to trade; Non-tariff measures; Foodborne diseases; Quality; Safety; Certification; Standard Certification; Economía; Maestría. |
Ano: 2014 |
URL: http://hdl.handle.net/10521/2245 |
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MALULY,Hellen Dea Barros; JOHNSTON,Craig; GIGLIO,Norberto Damián; SCHREINER,Ligia Lindner; ROBERTS,Ashley; ABEGAZ,Eyassu Getachew. |
Abstract The increase of the prevalence of type-2 diabetes as a consequence of overweight and obesity has stimulated public health authorities worldwide to develop strategies for its risk management and prevention. Among them, a reduction on the content of sugar in sugar-sweetened foods and beverages has been suggested, which led the food industry to replace partially sucrose with food additives, such as low- and no-calorie sweeteners (LNCS). As a consequence, there has been an increase of their consumption, which has made regulatory agencies to evaluate their exposure and possible consequences. At the same time, speculations about adverse effects, such as carcinogenicity, preterm delivery and metabolic changes involving appetite, weight increase and... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sweeteners; Safety; Regulation; Metabolism; Cancer. |
Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000100001 |
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Registros recuperados: 42 | |
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