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| oic-Vranic,T.; Bobinac,D.; Bajek,S.; Jerkovic,R.; Malnar-Dragojevic,D.; Nikolic,M.. |
| The objective of the present investigation was to perform a 14-day time-course study of treatment with salbutamol, a ß2 adrenoceptor agonist, on rat soleus muscle in order to assess fiber type selectivity in the hypertrophic response and fiber type composition. Male Wistar rats were divided into four groups: control (N = 10), treated with salbutamol (N = 30), denervated (N = 30), and treated with salbutamol after denervation (N = 30). Salbutamol was injected intraperitoneally in the rats of the 2nd and 4th groups at a concentration of 0.3 mg/kg twice a day for 2 weeks. The muscles were denervated using the crush method with pean. The animals were sacrificed 3, 6, 9, 12, and 14 days after treatment. Frozen cross-sections of soleus muscle were stained for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Salbutamol; Rat skeletal muscle; Soleus muscle; Denervation; Histochemistry; Muscle fibers. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200008 |
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| Kasahara,D.I.; Perini,A.; Lopes,F.D.T.Q.S.; Arantes-Costa,F.M.; Martins,M.A.; Nunes,M.P.T.. |
| Beta-2-agonists have been widely used by asthmatic subjects to relieve their obstructive symptoms. However, there are reports that continuous use could lead to loss of bronchial protection and exacerbation of asthma symptoms. We evaluated the effect of two regimens of salbutamol administration (twice and five times a week) in a model of chronic airway inflammation in male Hartley guinea pigs (protocol starting weight: 286 ± 30 g) induced by repeated exposures to aerosols of ovalbumin (OVA). After sensitization, guinea pigs were exposed to aerosols of 0.1 mg/ml salbutamol solution twice a week (OVA + S2x, N = 7) or five times a week (OVA + S5x, N = 8). We studied allergen-specific (OVA inhalation time) and -nonspecific (response to methacholine) respiratory... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Salbutamol; Methacholine; Experimental asthma; Beta-agonist; Pulmonary responsiveness. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500009 |
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| Viel,R.M.; Nogueira,R.M.B.; Kaneko,V.M.; Melchert,A.; Laposy,C.B.; Clemente,D.S.; Franz,E.. |
| Avaliaram-se, por meio de exame clínico, hemogasométrico e eletrocardiográfico, os efeitos do salbutamol e do fenoterol, administrados por via inalatória em cães. Doze cães foram distribuídos em dois grupos: os do grupo FE receberam fenoterol na dose de 2 gotas/5kg de peso vivo, diluídas em solução de cloreto de sódio 0,9% por aparelho de inalação, e os do grupo SA receberam salbutamol pelo dosador de aerossol, na dose de 100mg. Foram avaliados: frequência cardíaca (FC), frequência respiratória (FR), temperatura retal (TR), pressão arterial sistólica (PAS), hemogasometria e eletrocardiograma antes e após 30min, duas horas e seis horas do uso dos fármacos. Discreta estimulação cardíaca ocorreu nos animais do grupo SA duas horas após sua administração em... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cão; Fenoterol; Salbutamol; Inalação. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000100008 |
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