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Registros recuperados: 13 | |
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Mozafari,Roghayeh; Kyrylenko,Sergiy; Castro,Mateus Vidigal; Ferreira Jr,Rui Seabra; Barraviera,Benedito; Oliveira,Alexandre Leite Rodrigues. |
Abstract Background Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used. However, these surgical techniques result in nerve regeneration at highly variable degrees. It is thus very important to seek complementary techniques to improve motor and sensory recovery. One promising approach could be cell therapy. Transplantation therapy with human embryonic stem cells (hESCs) is appealing because these cells are pluripotent and can differentiate into specialized cell types and have self-renewal ability. Therefore, the main objective of this study was to find conditions under which functional... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neurorrhaphy; Sciatic nerve; Human embryonic stem cells; Fibrin sealant; FGF2. |
Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100305 |
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Sánchez Rodríguez,Nora; Bu Wong,Margarita; Pérez-Saad,Héctor Manuel; León Rodríquez,Niurka; García Salmán,Jorge Daniel. |
INTRODUCCIÓN: Spirulina platensis es una microalga verde-azul de alto valor nutricional, la cual ha sido empleada como suplemento dietético. Varios de sus constituyentes ayudan al mantenimiento de la estructura y función de los tejidos nerviosos. OBJETIVO: determinar el efecto de esta microalga en un modelo de neuropatía axonal inducida por acrilamida, en ratones. MÉTODOS: el modelo consistió en la administración diaria de 70 mg/kg de acrilamida, por vía subcutánea, durante 3 semanas consecutivas; con la estimación del efecto neurotóxico de este compuesto mediante el registro, en los músculos de la pierna, del potencial de acción muscular compuesto, durante la estimulación supramáxima del nervio ciático. Después de finalizar las inyecciones de acrilamida,... |
Tipo: Journal article |
Palavras-chave: Acrilamida; Nervio ciático; Neuropatía axonal; Neuroregeneración; Spirulina platensis; Acrylamide; Sciatic nerve; Axonal neuropathy; Neuroregeneration; Spirulina platensis. |
Ano: 2009 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962009000100006 |
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Leal-Cardoso,J.H.; Matos-Brito,B.G.; Lopes-Junior,J.E.G.; Viana-Cardoso,K.V.; Sampaio-Freitas,A.B.; Brasil,R.O.; Coelho-de-Souza,A.N.; Albuquerque,A.A.C.. |
Estragole, a relatively nontoxic terpenoid ether, is an important constituent of many essential oils with widespread applications in folk medicine and aromatherapy and known to have potent local anesthetic activity. We investigated the effects of estragole on the compound action potential (CAP) of the rat sciatic nerve. The experiments were carried out on sciatic nerves dissected from Wistar rats. Nerves, mounted in a moist chamber, were stimulated at a frequency of 0.2 Hz, with electric pulses of 50-100-µs duration at 10-20 V, and evoked CAP were monitored on an oscilloscope and recorded on a computer. CAP control parameters were: peak-to-peak amplitude (PPA), 9.9 ± 0.55 mV (N = 15), conduction velocity, 92.2 ± 4.36 m/s (N = 15), chronaxy, 45.6 ± 3.74 µs... |
Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Estragole; Essential oil; Sciatic nerve; Compound action potential; Nerve conduction velocity. |
Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800009 |
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Moreira,M.R.; Cruz,G.M.P.; Lopes,M.S.; Albuquerque,A.A.C.; Leal-Cardoso,J.H.. |
Terpineol, a volatile terpenoid alcohol of low toxicity, is widely used in the perfumery industry. It is an important chemical constituent of the essential oil of many plants with widespread applications in folk medicine and in aromatherapy. The effects of terpineol on the compound action potential (CAP) of rat sciatic nerve were studied. Terpineol induced a dose-dependent blockade of the CAP. At 100 µM, terpineol had no demonstrable effect. At 300 µM terpineol, peak-to-peak amplitude and conduction velocity of CAP were significantly reduced at the end of 180-min exposure of the nerve to the drug, from 3.28 ± 0.22 mV and 33.5 ± 7.05 m/s, respectively, to 1.91 ± 0.51 mV and 26.2 ± 4.55 m/s. At 600 µM, terpineol significantly reduced peak-to-peak amplitude... |
Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Essential oil; Alpinia speciosa; Zingiberaceae; Sciatic nerve; Compound action potential; Nerve conduction velocity. |
Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000015 |
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Sousa,D.G.; Sousa,S.D.G.; Silva,R.E.R.; Silva-Alves,K.S.; Ferreira-da-Silva,F.W.; Kerntopf,M.R.; Menezes,I.R.A.; Leal-Cardoso,J.H.; Barbosa,R.. |
Lippia alba is empirically used for infusions, teas, macerates, and hydroalcoholic extracts because of its antispasmodic, analgesic, sedative, and anxiolytic effects. Citral is a mixture of trans-geranial and cis-neral and is the main constituent of L. alba essential oil and possesses analgesic, anxiolytic, anticonvulsant, and sedative effects. The present study evaluated the effects of the essential oil of L. alba (EOLa) and citral on compound action potentials (CAPs) in Wistar rat sciatic nerves. Both drugs inhibited CAP in a concentration-dependent manner. The calculated half-maximal inhibitory concentrations (IC50) of peak-to-peak amplitude were 53.2 µg/mL and 35.00 µg/mL (or 230 µM) for EOLa and citral, respectively. Peak-to-peak amplitude of the CAP... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Citral; Nerve excitability; Lippia alba; Sciatic nerve; Essential oil; Compound action potential. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800697 |
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Alves,J.S.M.; Leal-Cardoso,J.H.; Santos-Júnior,F.F.U.; Carlos,P.S.; Silva,R.C.; Lucci,C.M.; Báo,S.N.; Ceccatto,V.M.; Barbosa,R.. |
Immobilization, used in clinical practice to treat traumatologic problems, causes changes in muscle, but it is not known whether changes also occur in nerves. We investigated the effects of immobilization on excitability and compound action potential (CAP) and the ultrastructure of the rat sciatic nerve. Fourteen days after immobilization of the right leg of adult male Wistar rats (n=34), animals were killed and the right sciatic nerve was dissected and mounted in a moist chamber. Nerves were stimulated at a baseline frequency of 0.2 Hz and tested for 2 min at 20, 50, and 100 Hz. Immobilization altered nerve excitability. Rheobase and chronaxy changed from 3.13±0.05 V and 52.31±1.95 µs (control group, n=13) to 2.84±0.06 V and 59.71±2.79 µs (immobilized... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Immobilization; Sciatic nerve; Compound action potential; Conduction velocity; Rheobase; Chronaxy. |
Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800715 |
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Horst,A.; de Souza,J.A.; Santos,M.C.Q.; Riffel,A.P.K.; Kolberg,C.; Ribeiro,M.F.M.; de Fraga,L.S.; Partata,W.A.. |
We determined the effect of N-acetylcysteine (NAC) on the expression of the phosphorylated p38 (p-p38) protein and superoxide anion generation (SAG), two important players in the processing of neuropathic pain, in the lumbosacral spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain. The sciatic functional index (SFI) was also measured to assess the functional recovery post-nerve lesion. Thirty-six male Wistar rats were divided equally into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve), which received 2, 4, or 8... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sciatic functional index; Chronic constriction; Sciatic nerve; Mitogen-activated protein kinase; Antinociception; Mechanical threshold. |
Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200605 |
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da Cunha,Marcelo Rodrigues; Laraia,Isabela Ortiz; Franco,Guacira R; Miguel,Natalia N; Maciel,Ana A; dos Santos,Geovane Ribeiro; Isayama,Ricardo Noboro. |
Bone metabolism is influenced by different factors and muscle activity acts as a stimulator of bone plasticity. Conditions such as nerve injuries can compromise bone physiology due to muscle inactivity. Preview studies have shown that nerve damage reduces P substance and calcitonin gene-related peptides, also known as neuropeptides that may have a key role on bone healing. Therefore, this study evaluated the osseointegration of hydroxyapatite implants in tibial defects of rats submitted to unilateral sciatic nerve section. Twelve Wistar rats were divided into two groups (G1 and G2). In G1, the sciatic nerve was left intact and in G2 the left sciatic nerve was completely sectioned. An experimental tibial bone defect was then created in both groups and... |
Tipo: Journal article |
Palavras-chave: Hydroxyapatite; Sciatic nerve; Bone healing. |
Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200033 |
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Aluclu,Mehmet Ufuk; Tuncer,Mehmet Cudi; Guzel,Aslan; Aluclu,Mustafa Arif; Akkus,Murat. |
We aimed to investigate the potential harmful effects of maternal valproic acid (VPA) on fetal sciatic nerve, and the protective effects of vitamin E (Vit E) and folic acid (FA) on fetal rats. Valproic acid (400mg/kg), folic acid (400mg/kg) and vitamin E (250 mg/kg) were administered to rats on each of gestation days 8-10. All fetuses were collected on gestation day 20. With thin sections of biopsies, sciatic nerve of fetuses were stained with uranyl acetat and were examined under transmission electron microscope. The fetuses (n:36) were divided into five groups: control, vpa, vpa+fa, vpa+vit e and vpa+fa+vit e groups. In each group; drug procedure, surgical procedure and histological methods were performed. Later, weights and lengths of fetuses in each... |
Tipo: Journal article |
Palavras-chave: Valproic acid; Sciatic nerve; Folic acid; Vitamin E; Rat. |
Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000200001 |
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Registros recuperados: 13 | |
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