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| Medeiros,Magda A.; Costa-e-Sousa,Ricardo H.; Olivares,Emerson L.; Côrtes,Wellington S.; Reis,Luís C.. |
| The role of serotonergic system in the feeding behaviorwas appraised by electrolytic lesions in the dorsal raphe nucleus (DRN) and administration of para-chlorophenylalanine (PCPA, 3 mg/5 mul, icv). Chronic evaluations were accomplished through 120 and 360 days in PCPA-injected and DRN-lesioned rats, respectively. Acute food intake was evaluated in fasted rats and submitted to injection of PCPA and hydroxytryptophan (LHTP, 30 mg/kg, ip). DRN-lesioned rats exhibited 22-80% increase in food intake up to sixth month, whereas the obesity was evident and sustained by whole period. In PCPA-injected rats was observed an initial increase in the food intake followed by hypophagy from 25th to 30th day and a transitory increase of body weight from 5th to 60th day. In... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Food ingestion; Serotonergic system; Dorsal raphe nucleus; Electrolytic lesion; Para-chlorophenylalanine; Obesity. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100008 |
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| Lima,Hawlinston R. C.; Cavalcante-Lima,Haerishton R.; Cedraz-Mercez,Pedro L.; Costa-E-Sousa,Ricardo H.; Olivares,Emerson L.; Badauê-Passos-Jr,Daniel; Medeiros,Magda A.; Côrtes,Wellington S.; Reis,Luís C.. |
| We investigate the influence of brain serotonin depletion on the sodium appetite. Rats depleted of serotonin through the systemic administration of p-chlorophenylalanine (300 mg/kg, ip, for 2 days) showed an intense natriorexigenic response induced by sodium depletion (furosemide, 20 mg/kg, sc, 24 h before water and 1.8% NaCl presentation). Intake of 1.8% NaCl was always higher than that observed for the control group (12.9 ± 1.4 and 21.4 ± 3.0 mL vs 5.7 ± 1.2 and 12.7 ± 1.6 mL, 30 and 300 min after water and saline presentation). After 24 h, the natriorexigenic response continued to be significantly higher compared to control (33.6±5.1 vs 21.9±3.6 mL,P <0.05). Fourteen days after p-chlorophenylalanine administration, 1.8% NaCl intake did not differ... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sodium appetite; Brain serotonin depletion; Sodium and water depletion; Isoproterenol; Serotonergic system. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100008 |
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| Cavalcante-Lima,H.R.; Badauê-Passos Jr.,D.; de-Lucca Jr.,W.; Lima,H.R.C.; Costa-e-Sousa,R.H.; Olivares,E.L.; Cedraz-Mercez,P.L.; Reis,R.O.; Medeiros,M.A.; Côrtes,W.S.; Reis,L.C.. |
| We determined if the dorsal raphe nucleus (DRN) exerts tonic control of basal and stimulated sodium and water intake. Male Wistar rats weighing 300-350 g were microinjected with phosphate buffer (PB-DRN, N = 11) or 1 µg/0.2 µl, in a single dose, ibotenic acid (IBO-DRN, N = 9 to 10) through a guide cannula into the DRN and were observed for 21 days in order to measure basal sodium appetite and water intake and in the following situations: furosemide-induced sodium depletion (20 mg/kg, sc, 24 h before the experiment) and a low dose of dietary captopril (1 mg/g chow). From the 6th day after ibotenic acid injection IBO-DRN rats showed an increase in sodium appetite (12.0 ± 2.3 to 22.3 ± 4.6 ml 0.3 M NaCl intake) whereas PB-DRN did not exceed 2 ml (P <... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sodium appetite; Water intake; Dorsal raphe nucleus; Serotonergic system; Ibotenic acid. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100015 |
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| Olivares,E.L.; Costa-e-Sousa,R.H.; Cavalcante-Lima,H.R.; Lima,H.R.C.; Cedraz-Mercez,P.L.; Reis,L.C.. |
| The present study determined the effect of an electrolytic lesion of the dorsal raphe nucleus (DRN) on water intake and sodium appetite. Male Wistar rats weighing 290-320 g with a lesion of the DRN (L-DRN), performed two days before experiments and confirmed by histology at the end of the experiments, presented increased sensitivity to the dehydration induced by fluid deprivation. The cumulative water intake of L-DRN rats reached 23.3 ± 1.9 ml (a 79% increase, N = 9) while sham-lesioned rats (SL-DRN) did not exceed 13.0 ± 1.0 ml (N = 11, P < 0.0001) after 5 h. The L-DRN rats treated with isoproterenol (300 µg kg-1 ml-1, sc) exhibited an increase in water intake that persisted throughout the experimental period (L-DRN, 15.7 ± 1.47 ml, N = 9 vs SL-DRN,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sodium appetite; Water intake; Dorsal raphe nucleus; Serotonergic system; Electrolytic lesion; Rats. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200013 |
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