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Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review BJPS
Cruz,Júlia Niehues da; Magro,Débora Delwing Dal; Lima,Daniela Delwing de; Cruz,José Geraldo Pereira da.
ABSTRACT Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs and, in turn, decrease NMDA-mediated anxiety. This hypothesis will contribute to understanding the critical roles of simvastatin in treating anxiety via the NMDA receptor.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anxiolytic effects; Membrane/lipid rafts; N-methyl-D-aspartate; Simvastatin..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100401
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Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N 3 -oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4 )palladium(II)} BJPS
Rampelotto,Roberta Filipini; Lorenzoni,Vinicius Victor; Silva,Danielly da Costa; Moraes,Guilherme A. de; Serafin,Marissa Bolson; Tizotti,Maísa Kräulish; Coelho,Silvana; Zambiazi,Priscilla; Hörner,Manfredo; Hörner,Rosmari.
Abstract The treatment of infections caused by resistant microorganisms represents a big challenge in healthcare due to limited treatment options. For this reason, the discovery of new active substances which are able to perform innovative and selective actions is of great impact nowadays. Statins and triazenes (TZC) have consolidated as a promising class of compounds, characterized by the expressive biological activity, especially antimicrobial activities. The aim of this study was to assess the in vitro synergistic antibacterial effect of the association of statins and a new TZC complex {[1-(4-bromophenyl)-3-phenyltriazene N 3-oxide-κ 2 N 1,O 4](dimethylbenzylamine-κ 2 C 1,N 4)palladium(II)} (Pd(DMBA)LBr) against American Type Culture Collection (ATCC)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Statins/antimicrobial activity; Triazenide; Atorvastatin; Simvastatin..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200614
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