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	Provedor de dados BJPS (1) Autor Araújo,Magali Benjamim (1) Figueiredo,Eduardo Costa (1) Lima,Ana Carolina Zogbi (1) Pereira,Gislaine Ribeiro (1) Perissinato,Aline Gravinez (1) Ruela,André Luís Morais (1) Mais... Palavra-chave Nicotine/release and skin permeation (1) Skin permeation (1) Transdermal delivery patches/evaluation (1) Transdermal formulations/nicotine delivery systems (1) Vertical diffusion cell (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil BJPS Ruela,André Luís Morais; Figueiredo,Eduardo Costa; Perissinato,Aline Gravinez; Lima,Ana Carolina Zogbi; Araújo,Magali Benjamim; Pereira,Gislaine Ribeiro. The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical diffusion cell (VDC). The VDC is an experimental apparatus employed in research, development, and the pharmaceutical field because it can simulate conditions closest to those established in clinical trials. Two transdermal nicotine delivery systems marketed in Brazil to release 14 mg over 24 hours were evaluated. Release studies were carried out using a regenerated cellulose dialysis membrane and permeation studies were carried out using excised porcine ear skin. The results indicated that nicotine release from both evaluated patches follows Higuchi's release kinetics, while skin permeation studies... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nicotine/release and skin permeation; Transdermal delivery patches/evaluation; Vertical diffusion cell; Skin permeation; Transdermal formulations/nicotine delivery systems. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300020 Registros recuperados: 1 Primeira ... 1 ... Última

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