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Simultaneous RP-HPLC determination of sparfloxacin and dexamethasone in pharmaceutical formulations BJPS
Razzaq,Syed Naeem; Ashfaq,Muhammad; Mariam,Irfana; Khan,Islam Ullah; Razzaq,Syed Saleem.
The present study describes the development and subsequent validation of simple and accurate stability indicating RP-HPLC method for the determination of sparfloxacin and dexamethasone in pharmaceutical formulations in the presence of their stress-induced degradation products. Both the drugs and their stress-induced degradation products were separated within 10 minutes using C8 column and mixture of methanol and 0.02 M phosphate buffer pH 3.0 (60:40 v/v, respectively) as mobile phase at 270 nm using diode array detector. Regression analysis showed linearity in the range of 15-105 µg/mL for sparfloxacin and 5-35 µg/mL for dexamethasone. All the analytes were adequately resolved with acceptable tailing. Peak purity of the two drugs was also greater than...
Tipo: Info:eu-repo/semantics/article Palavras-chave: RP-HPLC; Sparfloxacin; Dexamethasone; Degradation products; Stability studies.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200012
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