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Alterações bioquímicas em larvas de Danio rerio por exposição à mistura de herbicidas. Repositório Alice
MOURA, M. A. M.; OLIVEIRA, R.; DOMINGUES, I.; JONSSON, C. M.; NOGUEIRA, A. J. A..
Resumo: A cana-de-açúcar é o carro-chefe da agricultura paulista e o Brasil é líder mundial na produção do etanol em larga escala, um combustível renovável que contribui para a redução da emissão de gases de efeito estufa, por evitar a queima de combustíveis fósseis. A alta produtividade desta cultura necessita, entretanto, do uso intensivo de defensivos agrícolas, que podem contaminar mananciais próximos às áreas de cultivo ou mesmo serem transportados afetando ecossistemas distantes. O uso simultâneo de diferentes herbicidas é comum nas lavouras, mas sua interação e o impacto sobre espécies não-alvo não são bem conhecidos. O objetivo deste trabalho foi avaliar o efeito da mistura de herbicidas ametrina e diuron, usada na lavoura canavieira, sobre o...
Tipo: Separatas Palavras-chave: Toxicidade aguda; Ametrina.; Herbicida; Agrotóxico; Cana de açúcar; Peixe de água doce; Toxidez; Sinergismo; Herbicides; Sugarcane; Danio rerio; Freshwater fish; Ecotoxicology; Synergism; Diuron; Endpoints..
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1007542
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ANTAGONISM IS THE PREDOMINANT EFFECT OF HERBICIDE MIXTURES USED FOR IMIDAZOLINONE-RESISTANT BARNYARDGRASS (Echinochloa crus-galli) CONTROL Planta Daninha
MATZENBACHER,F. O.; KALSING,A.; DALAZEN,G.; MARKUS,C.; MEROTTO JR,A..
ABSTRACTHerbicides mixtures are used in many situations without the adequate knowledge related with the effect on major target weeds. The objective of this study was to evaluate the effects of different herbicides mixtures used in irrigated rice in order to establish the adequate combinations for the prevention and management of herbicide resistance in barnyardgrass (Echinochloa crus-galli). Three experiments were performed at field conditions with all major post-emergent herbicides used in irrigated rice in Brazil. The first experiment was performed with barnyardgrass resistant to imidazolinone herbicides and herbicides applied at label rates. The second and third experiments were performed with barnyardgrass resistant and susceptible to imidazolinone...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ALS inhibitors; Irrigated rice; Interaction; Synergism.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582015000300587
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Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method J. Venom. Anim. Toxins incl. Trop. Dis.
Mantovani,R. P.; Rall,V. L. M.; Batalha,J. E. N.; Fernandes,A. A. H.; Fernandes Junior,A..
Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South of Brazil on coagulase-negative Staphylococcus (CNS) growth as well as the EEP in vitro synergism with antimicrobial drugs by using the diffusion method (E-test). The EEP chemical characteristics (dry weight, pH, flavonoid and phenolic compounds) were determined. Seven drugs were tested, and synergism was observed between three drugs and Southeast EEP, six drugs and South EEP, and one drug and ethanol control. Ethanolic extracts of propolis from the South of Brazil presented the greatest flavonoid content...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brazilian propolis; Coagulase-negative Staphylococcus; E-test; Antimicrobial drugs; Synergism.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200012
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Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates BJID
Kubiça,Thaís Felli; Denardi,Laura Bedin; Azevedo,Maria Isabel; Oliveira,Vanessa; Severo,Luiz Carlos; Santurio,Janio Morais; Alves,Sydney Hartz.
ABSTRACT The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of both fluconazole-susceptible and fluconazole-resistant Trichosporon asahii. For these analyses, we used the broth microdilution method based on the M27-A3 technique and checkerboard microdilution method. Tacrolimus showed no activity against T. asahii strains (minimal inhibitory concentrations, MICs > 64.0 µg mL−1). However, a larger synergistic interaction was observed by the combinations tacrolimus + amphotericin B (96.67%) and tacrolimus + caspofungin...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Susceptibility; FK506; Resistance; Synergism.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600539
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Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin BJM
Dutta,Noton K.; Dastidar,Sujata G.; Kumar,Asok; Mazumdar,Kaushiki; Ray,Raja; Chakrabarty,Atindra N..
Diclofenac sodium, an antiinflammatory agent, exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This drug was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 µg/ml concentration. When tested in vivo, diclofenac, injected at 10 µg/g body weight of a Swiss strain of white mice, could significantly protect them when challenged with 50 median lethal dose of M. tuberculosis H37 Rv 102. According to chi2 test, the in vivo data were highly significant (p<0.01). Diclofenac was further tested for synergism with the conventional antimycobacterial drug streptomycin against M. smegmatis...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antiinflammatory drug; Diclofenac sodium; Antimycobacterial activity; Streptomycin; Synergism; Non-antibiotic.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000300009
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Avaliação de frações do óleo de Piper aduncum L. como sinérgicas de inseticidas carbamatos e espinosinas. Repositório Alice
LIMA, M. E. C. de; FAZOLIN, M.; MONTEIRO, A. F. M..
O objetivo deste trabalho foi avaliar a eficácia sinérgica das combinações das frações do óleo essencial de P. aduncum ricas em monoterpenos e sesquiterpenos, com inseticidas químicos (carbamato e espinosinas), por contato tópico e residual de larvas de terceiro instar da lagarta-docartucho-do-milho Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae).
Tipo: Parte de livro Palavras-chave: Terpenóides; Espinosina; Spinosyn; Metomil; Inseticida de Origem Vegetal; Óleo Essencial; Pimenta de Macaco; Sinergismo; Carbamato; Botanical insecticides; Essential oils; Piper aduncum; Synergism; Terpenoids; Carbamates; Spinosad.
Ano: 2022 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1145942
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Avaliação inseticida de composições químicas por adição de monoterpenos, sesquiterpenos e fenilpropanoides ao dilapiol. Repositório Alice
LIMA, M. E. C. de; OLIVEIRA, H. K. G.; MONTEIRO, A. F. M.; FAZOLIN, M..
As classes de compostos mais comuns que ocorrem nos óleos essenciais são de terpenos (monoterpenos, sesquiterpenos, etc.) e fenilpropanoides. Embora a bioatividade de óleos essenciais seja geralmente atribuída a alguns compostos majoritários como dilapiol, um fenômeno sinérgico entre metabólitos pode resultar em uma maior bioatividade em comparação com os componentes isolados. Informações sobre as relações mútuas de substâncias aromáticas contidas nos óleos essenciais podem ser importantes, particularmente no desenvolvimento de formulações de inseticidas botânicos ou na normalização do conteúdo de substâncias ativas que asseguram a eficácia biológica. Combinações específicas de compostos de ocorrência minoritária com o dilapiol, obtidas de forma...
Tipo: Parte de livro Palavras-chave: Oruga; Aceites essenciales; Insecticidas botánicos; Dilapiol; Fall armyworm; Cartucho-do-milho; Caterpillar; Monoterpeno; Monoterpenoides; Fenilpropanoides; Fitotoxicidad; Larvas de insectos; Embrapa Acre; Rio Branco (AC); Acre; Amazônia Ocidental; Western Amazon; Amazonia Occidental.; Pimenta de Macaco; Fitotoxicidade; Lagarta; Spodoptera Frugiperda; Larva.; Inseticida de Origem Vegetal; Óleo Essencial; Sinergismo; Essential oils; Piper aduncum; Botanical insecticides; Synergism; Monoterpenoids; Sesquiterpenoids; Phenylpropanoids; Phytotoxicity; Insect larvae..
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1110979
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Bactericidal antibiotic-phytochemical combinations against methicillin resistant Staphylococcus aureus BJM
Kyaw,Bhone Myint; arora,Shuchi; Lim,Chu Sing.
Methicillin resistant Staphylococcus aureus (MRSA) infection is a global concern nowadays. Due to its multi-drug resistant nature, treatment with conventional antibiotics does not assure desired clinical outcomes. Therefore, there is a need to find new compounds and/or alternative methods to get arsenal against the pathogen. Combination therapies using conventional antibiotics and phytochemicals fulfill both requirements. In this study, the efficacy of different phytochemicals in combination with selected antibiotics was tested against 12 strains of S. aureus (ATCC MRSA 43300, ATCC methicillin sensitive S. aureus or MSSA 29213 and 10 MRSA clinical strains collected from National University Hospital, Singapore). Out of the six phytochemicals used, tannic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phytochemicals; Antibiotic combinations; Synergism; Antibiotic resistance; Methicillin-resistance Staphylococcus aureus (MRSA).
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000300013
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Biological properties of medicinal plants: a review of their antimicrobial activity J. Venom. Anim. Toxins incl. Trop. Dis.
Silva,NCC; Fernandes Júnior,A.
Plants have been used for thousands of years to flavor and conserve food, to treat health disorders and to prevent diseases including epidemics. The knowledge of their healing properties has been transmitted over the centuries within and among human communities. Active compounds produced during secondary vegetal metabolism are usually responsible for the biological properties of some plant species used throughout the globe for various purposes, including treatment of infectious diseases. Currently, data on the antimicrobial activity of numerous plants, so far considered empirical, have been scientifically confirmed, concomitantly with the increasing number of reports on pathogenic microorganisms resistant to antimicrobials. Products derived from plants may...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medicinal plants; Phytochemistry; Antimicrobial activity; Plant extracts; Essential oils; Synergism.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300006
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Chemical characterization UPLC-ESI-QToF-MSE, antibacterial and antibiofilm potential of Sarcomphalus joazeiro (MART.) Hauenschild. Repositório Alice
ARAÚJO, N. J. S.; SILVA, A. R. P.; COSTA, M. S.; FREITAS, T. S.; BARBOSA FILHO, J. M.; MATOS, Y. M. L. S.; MORAIS-BRAGA, M. F. B.; PEREIRA JUNIOR, F. N.; SILVA, C. A. P.; SOUZA, E. O.; RIBEIRO, P. R. V.; LACERDA, B. C. G. V. DE; ANDRADE, E. M. DE; COUTINHO, H. D. M.; ANDRADE-PINHEIRO, J. C..
Tipo: Artigo de periódico Palavras-chave: Inhibition; Inibição; Biofilme; Saponina; Sinergismo; Biofilm; Saponins; Synergism.
Ano: 2022 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1149828
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Chemical composition and fumigant effect of essentialoil of Lippia sidoides Cham. and monoterpenes against Tenebrio molitor (L.) (coleoptera: tenebrionidae) Ciência e Agrotecnologia
Lima,Rafaela Karin; Cardoso,Maria das Graças; Moraes,Jair Campos; Carvalho,Stephan Malfitano; Rodrigues,Vanessa Gregório; Guimarães,Luiz Gustavo Lima.
The chemical composition of Lippia sidoides essential oils obtained by hydrodistillation was characterized and quantified by GC/MS and their insecticidal activity by fumigation test was assayed against Tenebrio molitor. Moreover, the toxicity of monoterpenes carvacrol, 1,8-cineol and thymol were also evaluated when applied alone or in binary (1:1) or tertiary (1:1:1) mixture. The essential oil of L. sidoides has as major constituents carvacrol (31.68%), ρ-cymene (19.58%), 1,8-cineole (9.26%) and ϒ-terpinene (9.21%), from a 21 compounds identified, being 92.53% of total. Both compounds have insecticidal activity against T. molitor, being the degree of toxicity of carvacrol > 1,8-cineole > L. sidoides essential oil > thymol, and its respectively...
Tipo: Info:eu-repo/semantics/article Palavras-chave: "Alecrim pepper"; Mealworm; Natural compound; Toxicity; Synergism.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542011000400004
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Combined effects of garlic essential oil and allyl isothiocyanate against Escherichia coli O157:H7 in vitro and in pork sausage Ciência Rural
Bortolotto,Fernanda Cristina Kandalski; Ceccoti,Stephane Pini Costa; Orso,Paloma Bianca; Wolupeck,Hanna Lethycia; Holley,Richard Alan; Luciano,Fernando Bittencourt; Macedo,Renata Ernlund Freitas de.
ABSTRACT: Escherichia coli O157:H7 is a toxigenic serotype of E. coli and has been associated with foodborne outbreaks involving meat products, vegetables and fresh produces worldwide. Salts for curing are usually employed as antimicrobials in the production of pork sausages. However, salts do not have a significant inhibitory effect on enterobacteria. Due to the growing demand for natural foods, the use of essential oils has been proposed as natural antimicrobials in food. This study aimed to evaluate the effects of garlic essential oil (GO) and allyl isothiocyanate (AITC) against E. coli O157:H7 in vitro and in pork sausage. The Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) of these oils, alone and in combination,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Foodborne pathogens; Meat products; Natural preservatives; Synergism.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018001000750
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Commelina Species Control with Desiccants Alone and in Mixtures Planta Daninha
FERREIRA,S.D.; SALVALAGGIO,A.C.; MORATELLI,G.; VASCONCELOS,E.D.; COSTA,N.V..
ABSTRACT: The objective of this study was to evaluate the chemical control of the species C. benghalensis and C. erecta with desiccants alone and mixtures, as well as the spreading of spray droplets on the leaf surfaces. The experimental design was completely randomized in a 2 x 16 factorial arrangement with four replications, totaling 32 treatments and 128 plots. The first factor is related to the species C. benghalensis and C. erecta and the second factor corresponds to the treatments carfentrazone-ethyl in doses of 15, 30, 60 g ha-1, which added 0.5% v v-1 adhesive spreader; glufosinate ammonium at doses of 100, 200, 400 g ha-1, added 0.5% v v-1 mineral oil; glyphosate at 240, 480, 960 g ha-1; carfentrazone-ethyl + glufosinate ammonium in doses of 100,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Weed; Droplets surface tension; Spreader and sticker agent; Chemical control; Synergism.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582017000100278
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Determinação da atividade inseticida de clorantraniliprole em Chrysodeixis includens em m¡stura com Bacillus thuringiensis. Repositório Alice
NEIVA, M. M.; SÓSA-GOMEZ, D. R.; OLIVEIRA, M. C. N. de; GIOLO, S. R..
Conteúdo do volume 2: Ácaros; Biologia, fisiologia, morfologia; Controle biológico com bactérias entomopatogênicas; Controle biológico com fungos entomopatológicos; Controle biológico com nematoides; Controle biológico com parasitoides; Controle biológico com predadores; Ecologia e biodiversidade; Educação e etnoentomologia; Entomologia florestal; Entomologia Forense; Entomologia médica e veterinária; Entomologia molecular; Manejo integrado de pragas; Organismos geneticamente modificados; Plantas inseticidas; Polinização; Pragas quarentenárias e invasivas; Resistência de insetos a táticas de controle; Resistência de plantas a insetos; Semioquímicos e comportamento; Sistemática e taxonomia; Tecnologia de aplicação; Controle biológico com vírus...
Tipo: Separatas Palavras-chave: Soja; Sinergismo; Lagarta; Inseticida; Soybeans; Synergism; Pesticide synergists; Plant pests.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1100095
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Determinação da atividade inseticida de clorantraniliprole em Spodoptera frugiperda em m¡stura com Bacillus thuringiensis. Repositório Alice
NEIVA, M. M.; OLIVEIRA, M. C. N. de; GIOLO, S. R.; SÓSA-GOMEZ, D. R..
Conteúdo do volume 2: Ácaros; Biologia, fisiologia, morfologia; Controle biológico com bactérias entomopatogênicas; Controle biológico com fungos entomopatológicos; Controle biológico com nematoides; Controle biológico com parasitoides; Controle biológico com predadores; Ecologia e biodiversidade; Educação e etnoentomologia; Entomologia florestal; Entomologia Forense; Entomologia médica e veterinária; Entomologia molecular; Manejo integrado de pragas; Organismos geneticamente modificados; Plantas inseticidas; Polinização; Pragas quarentenárias e invasivas; Resistência de insetos a táticas de controle; Resistência de plantas a insetos; Semioquímicos e comportamento; Sistemática e taxonomia; Tecnologia de aplicação; Controle biológico com vírus...
Tipo: Separatas Palavras-chave: Sinergismo; Soja; Inseticida; Praga de Planta; Soybeans; Synergism; Pesticide synergists; Plant pests.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1100102
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Dichotomy between urban and rural areas: statistical data may not reveal the synergy between these two existing spaces. Repositório Alice
CAMPOS, W. P.; SILVEIRA, M. A. da; CALIARI, M.; WANDER, A. E..
An analysis of several indicators, socio-economic and environmental, through the Dashboard of Sustainability is possible to tell which category has the highest rate of farmer sustainability, whether smallholders or monoculture. However, the secondary data available in Brazil today does not support a thorough analysis of the participation of each actor and to which the interconnection between the actors and their synergy in local economic activity. Since, given the narrowing between urban and rural, the statistical data available are not able to demonstrate the extent to which gives the rural-urban dichotomy. Thus, it is relevant to point out and discuss ways to provide consistent statistical data and be, in fact, able to demonstrate the local reality of a...
Tipo: Parte de livro Palavras-chave: Dicotomia; Área rural; Área urbana; Estatística; Economia; Welfare economics; Synergism; Rural areas.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1018000
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Dipyridamole increases the cytotoxicity of cisplatin in human larynx cancer cells in vitro BJMBR
Rodrigues,M.; Barbosa Junior,F.; Perussi,J.R..
This paper describes the effect of dipyridamole (DIP) on the cytotoxicity of cisplatin in HEp-2 human larynx cancer cells in vitro and the nature of the interaction between cisplatin and dipyridamole. Cytotoxic assays were performed to obtain the IC50 for cisplatin. The cells were treated with 0, 20, 40, 80, 120 or 200 µM cisplatin, with or without a single concentration of DIP and incubated for 60 min at 37ºC and 5% CO2 for 3 days and then counted with a hemocytometer. The accumulation of cisplatin in the cells was measured by atomic absorption and fluorescence was used to determine the membrane binding constant of DIP. In the presence of 10, 20 and 30 µM DIP, the IC50 of cisplatin was reduced by 25, 60 and 82% in HEp-2 cells. Combination index analysis...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cisplatin; Dipyridamole; Synergism; Tumor cells; Cytotoxicity; IC50.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400017
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Effects of single and double infections with Potato virus X and Tobacco mosaic virus on disease development, plant growth, and virus accumulation in tomato Trop. Plant Pathol.
BALOGUN,OLUSEGUN S.; XU,LEIXIN; TERAOKA,TOHRU; HOSOKAWA,DAIJIRO.
The tomato cv. Fukuju nº. 2 was used for studying the effect of single and double infections with Potato virus X (PVX) and Tobacco mosaic virus (TMV). Mixed infection resulted in a synergistic increase of disease severity, where more growth reduction was seen with simultaneous inoculations than with sequential inoculations at four-day intervals. At five and 12 days post-inoculation, the increased severity of the disease coincided with enhancement of virus accumulation in the rapidly expanding upper leaves. The PVX concentration in leaves nº 5 to 7 of doubly infected plants was three to six fold that of singly infected ones, as determined by DAS-ELISA. Mixed infection with the L strain led to higher enhancement of PVX than with the TMV-L11A strain. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Synergism; Western blot; Northern hybridization; DAS-ELISA; Virus enhancement.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-41582002000300001
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Eficácia sinérgica de diferentes frações do óleo essencial de Piper aduncum L. para inseticidas utilizados no controle da lagarta-do-cartucho-do-milho. Repositório Alice
LIMA, R. P. Q de; MONTEIRO, A. F. M.; FAZOLIN, M..
Sinergistas como o óleo essencial de Piper aduncum L. (OEPA) são utilizados no manejo da resistência. O OEPA apresenta o dilapiol como componente majoritário, e estes compostos geralmente determinam as propriedades biológicas, sendo possível a modulação adicional de outros compostos minoritários. O objetivo desse trabalho foi o de avaliar a eficácia sinérgica de 6 frações do OEPA, para os inseticidas deltametrina e bifentrina.
Tipo: Parte de livro Palavras-chave: Dilapiol; Dilapidol; Bifentrina; Deltametrina; Terpeno; Laboratório de Entomologia; Embrapa Acre; Rio Branco (AC); Acre; Amazônia Ocidental; Western Amazon; Amazonia Occidental; Bifentrin; Aceites esenciales; Terpenoidos.; Insecticidas con piretroides; Deltametrín; Pimenta de macaco; Óleo essencial; Sinergismo; Inseticida piretróide; Piper aduncum; Essential oils; Terpenoids; Synergism; Pyrethroid insecticides; Deltamethrin; Bifenthrin..
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1089845
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Enhancement of domoic acid neurotoxicity on Diptera larvae bioassay by marine fungal metabolites ArchiMer
Ruiz, Nicolas; Petit, Karina; Vansteelandt, Marieke; Kerzaon, Isabelle; Baudet, Joseph; Amzil, Zouher; Biard, Jean-francois; Grovel, Olivier; Pouchus, Yves Francois.
Peptaibols are small linear fungal peptides which are produced in the marine environment. They exhibit neurotoxicity by forming pores in neuronal membranes. This work describes their combine effect with domoic acid, a neurotoxic phycotoxin, on Diptera larvae. The Acute toxicity bioassay on this biological model was tested with a panel of different toxins (microbial, algal or fungal). It allowed the discrimination of neurotoxins and non-neurotoxic toxins, and an evaluation of the toxicity level (MED and ED50) which were correlated with published LD50 in mice for neurotoxins tested. The highest activities on this test were found for Na+ channel blockers tetrodotoxin (ED50 = 0.026 mg/kg) and saxitoxin (ED50 = 0.18 mg/kg). Domoic acid was less active with an...
Tipo: Text Palavras-chave: Domoic acid; Peptaibol; Synergism; Neurotoxicity; Marine-derived fungal metabolite; Diptera larvae bioassay.
Ano: 2010 URL: http://archimer.ifremer.fr/doc/00002/11279/7886.pdf
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