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The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway BJMBR
Chen,Jian Xia; Yi,Xi Juan; Gu,Pei Ling; Gao,Shan Xia.
The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients with uterine septum who had normal endometrium verified with an uteroscope. In addition, 50 rats were randomly assigned into Control, Sham, Model, NC-siRNA, and KDR-siRNA groups. Rats in the Model, NC-siRNA, and KDR-siRNA groups were induced by uterine curettage and lipopolysaccharide (LPS) treatment to establish the IUA model. Then, immunohistochemistry was applied for detection of VEGF and KDR expression, HE staining was used for observation of the endometrial morphology and gland counting, Masson...
Tipo: Info:eu-repo/semantics/article Palavras-chave: KDR; Intrauterine adhesions; TGF-β1/Smads; MMP9; VEGF.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000607
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