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131I-induced changes in rat thyroid gland function BJMBR
Torlak,V.; Zemunik,T.; Modun,D.; Capkun,V.; Pesutic-Pisac,V.; Markotic,A.; Pavela-Vrancic,M.; Stanicic,A..
Therapeutic doses of 131I administered to thyrotoxic patients may cause thyroid failure. The present study used a rat model to determine thyroid function after the administration of different doses of 131I (64-277 µCi). Thirty male Fisher rats in the experimental group and 30 in the control group (untreated) were followed for 6 months. The animals were 4 months old at the beginning of the experiment and were sacrificed at an age of 9 months. Hormone concentration was determined before 131I administration (4-month-old animals) and three times following 131I administration, when the animals were 7, 8, and 9 months old. The thyroid glands were removed and weighed, their volume was determined and histopathological examination was performed at the end of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thyroid gland; 131I; Hormones; Histopathology; T3; T4; TSH.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800009
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Effects of rapeseed meal-glucosinolates on thyroid metabolism and feed utilization in rainbow trout ArchiMer
Burel, Christine; Boujard, Thierry; Kaushik, Sadasivam; Boeuf, Gilles; Mol, K; Van Der Geyten, S; Darras, V; Kuhn, E; Pradet Balade, B; Querat, B; Quinsac, A; Krouti, M; Ribaillier, D.
Two rapeseed meals (RM1 and RM2), containing glucosinolates at a concentration of 26 and 40 mumol/g, respectively, were incorporated at increasing levels (10, 20, and 30% for RM1 and 30 and 50% for RM2) in diets of juvenile rainbow trout. Disturbances in the thyroid axis appeared after 14 days of feeding (with a dietary incorporation level of 10%). The dietary supplementation with T-3 or iodine induced an increase in plasma T-3 levels, compared to that in fish fed the RM diets, and reduced the deleterious effect of RM on growth. When trout were reared in seawater, there was also a slight increase in thyroid hormone levels. TSH treatment had no effect on the thyroid hormone plasma levels. The incorporation of 30% of RM1, which induced a lower dietary...
Tipo: Text Palavras-chave: Rainbow trout; Iodine; TSH; Deiodinase activity; Thyroid function; Growth; Glucosinolates; Rapeseed.
Ano: 2001 URL: http://archimer.ifremer.fr/doc/2001/publication-677.pdf
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