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Ordenar por: RelevânciaAutorTítuloAnoImprime registros no formato resumido
Registros recuperados: 8
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A literature review on cardiovascular risk in human immunodeficiency virus-infected patients: implications for clinical management BJID
Gomes Neto,Mansueto; Zwirtes,Ricardo; Brites,Carlos.
INTRODUCTION: In recent years, there has been growing concern about an increasing rate of cardiovascular diseases in human immunodeficiency virus-infected patients, which could be associated with side effects of highly active antiretroviral therapy. It is likely that the metabolic disorders related to anti-human immunodeficiency virus treatment will eventually translate into a increased cardiovascular risk in patients submitted to such regimens. OBJECTIVE: To evaluate if human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy are at higher risk of cardiovascular diseases than human immunodeficiency virus infected patients not receiving highly active antiretroviral therapy, or the general population. RESEARCH DESIGN AND...
Tipo: Info:eu-repo/semantics/article Palavras-chave: AIDS; Therapeutics; Highly active antiretroviral therapy; Cardiovascular diseases.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600011
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Advances in biliary atresia: from patient care to research BJMBR
Santos,J.L.; Carvalho,E.; Bezerra,J.A..
Biliary atresia, the most common cause of liver transplantation in children, remains a challenge for clinicians and investigators. The development of new therapeutic options, besides the typical hepatoportoenterostomy, depends on a greater understanding of its pathogenesis and how it relates to the clinical phenotypes at diagnosis and the rate of disease progression. In this review, we present a perspective of how recent research has advanced the understanding of the disease and has improved clinical care protocols. Molecular and morphological analyses at diagnosis point to the potential contributions of polymorphism in the CFC1 and VEGF genes to the pathogenesis of the disease, and to an association between the degree of bile duct proliferation and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Biliary atresia; Etiology; Prognosis; Therapeutics.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000600001
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An in vivo test to assess mefloquine 25 mg/kg for the treatment of uncomplicated falciparum malaria in Rondônia, Brazil BJID
Basano,S.A.; Bianco,A.; Taylor,W.R..J; Olliaro,P.; Camargo,L.M.A..
Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Malaria; Mefloquine; Amazon; Rondônia; Therapeutics.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400013
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Anaphylatic reaction after Crotalus envenomation treatment in a dog: case report J. Venom. Anim. Toxins incl. Trop. Dis.
Conceição,L. G.; Argôlo Neto,N. M.; Castro,A. P.; Faria,L. B. A.; Fonterrada,C. O..
Crotalus envenomation is the second most frequent condition caused by venomous snakes attacking dogs and cats in Brazil. Affected animals show severe neurological and muscular involvement, lower motor neuron signs and myalgia due to extensive rabdomiolysis. The present case report is about Crotalus envenomation in a dog which showed severe clinical and laboratory abnormalities. After treatment with antivenom (specific antidote) and clinical support, the dog totally recovered from that condition.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Crotalus; Dogs; Snake bites; Therapeutics; Anaphylaxis.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200012
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How to Evaluate and Interpret a Scientific Article About Therapy Or Therapeutic Procedures? International Journal of Morphology
Otzen,Tamara; Manterola,Carlos; García-Domínguez,Maricela.
Regardless of the subject area and design used, it has been verified that between 40% and 60% of the studies published in biomedical journals are articles about therapy or therapeutic procedures (TP). Anyone writing a manuscript related to therapy or TP or reading an article of this type must demand at the very least a clear, precise and concise objective with respect to the research conducted, explicit mention of the design used with the respective inherent methodological details, and the mention and execution of statistical tools and the measures of association, or at least the numbers needed to calculate these values. The aim of this manuscript is to present a synthesis of the fundamental elements for the correct writing, reading and assessment of such...
Tipo: Journal article Palavras-chave: Therapeutics; Therapy; Subheading; Risk; Clinical Trial; Publication Type; Cohort Studies; Meta-Analysis; Publication Type.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200061
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Multi-drug resistance (MDR1) gene and P-glycoprotein influence on pharmacokinetic and pharmacodymanic of therapeutic drugs Ciência Rural
Linardi,Renata Lehn; Natalini,Cláudio Corrêa.
(MDR1) gene expressed in tumor cells and also in several normal tissues, such as intestine, liver, kidney, blood-brain barrier, spinal cord, and placenta. P-gp has been identified in mice, rat, bovine, monkey, rodents, and human beings and has been receiving a particular clinical relevance because this protein expression limits brain access and intestinal absorption of many drugs. This protein plays a role as a protective barrier against a wide variety of substrates, avoiding drug entry into the central nervous system. P-glycoprotein also interferes with drug bioavailability and disposition, including absorption, distribution, metabolization, and excretion, influencing pharmacokinetic and pharmacodynamic of drugs. Modulation of P-gp may help the efficacy...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MDR1 gene; P-glycoprotein; Therapeutics; Pharmacology.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100056
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Poison as cure: a clinical review of botulinum toxin as an invaluable drug J. Venom. Anim. Toxins incl. Trop. Dis.
Bali,J.; Thakur,R..
Botulinum toxin is the most potent toxin known. It is readily absorbed from mucosal surfaces. If dispersed as an aerosol or mixed in the food or water it can lead to a large outbreak of botulism. The disease presents as a symmetric descending paralysis in an afebrile patient. Cranial nerve involvement with diplopia, dysarthria, dysphonia, dysphagia and respiratory paralysis is seen after a variable incubation period. The treatment is mainly supportive. The source of the toxin is Clostridium botulinum, an anaerobic gram-positive spore-forming organism. Some other species of Clostridium like C. butyricum and C. baratii also produce the toxin. The toxin is heat labile and can be inactivated by heating at 100°C for 10 minutes. The toxin acts at the peripheral...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Botulinum toxin; Mechanism of action; Botulism; Therapeutics.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400003
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Therapeutic effects of Sophora moorcroftiana alkaloids in combination with albendazole in mice experimentally infected with protoscolices of Echinococcus granulosus BJMBR
Ma,X.M.; Bao,G.SH.; Wan,J.M.; Liao,D.J.; Yin,SH.F.; Meng,X.Q.; Zhou,G.K.; Lu,X.M.; Li,H.Y..
The objective of the present study was to determine if the combination of alkaloids from Sophora moorcroftiana seeds and albendazole might be effective in the treatment of experimental echinococcosisin female NIH mice (6 weeks old and weighing 18-20 g, N = 8 in each group) infected withprotoscolices of Echinococcus granulosus. Viable protoscolices (N = 6 x 103) were cultured in vitro in 1640 medium and mortality was calculated daily. To determine the in vivo efficacy, mice were inoculated intraperitoneally with viable protoscolices and then treated once daily by gavage for three months with the alkaloids (50 mg kg-1 day-1) and albendazole (50 mg kg-1 day-1), separately and in combination (both alkaloids at 25 mg kg-1 day-1 and albendazole at 25 mg kg-1...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sophora moorcroftiana; Echinococcus granulosus; Alkaloids; Cytokines; Ethnobotany; Therapeutics.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000014
Registros recuperados: 8
Primeira ... 1 ... Última
 

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