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Antioxidant activity of six Portuguese thyme species essential oils IPB - Escola Superior Agrária
Dandlen, S. Anahi; Lima, A. Sofia; Mendes, Marta D.; Miguel, M. Graça; Faleiro, M. Leonor; Sousa, Maria João; Pedro, Luis G.; Barroso, José G.; Figueiredo, A. Cristina.
The essential oils of Thymus caespititius, T. camphoratus, T. capitellatus, T. carnosus, T. pulegioides, T. zygis subsp. zygis and T. zygis subsp. sylvestris collected in diff erent regions of Portugal, including the Azores islands, were evaluated for preventing lipid peroxidation and scavenging free radicals, and hydroxyl and superoxide anions. T. zygis subsp. zygis oil possessed the best capacity for preventing lipid peroxidation (IC50 = 0.030 ± 0.003 mg/ml), immediately followed by the oils isolated from T. zygis subsp. sylvestris collected in diff erent regions of Portugal. IC50 values ranged from 0.066 ± 0.003 to 0.087 ± 0.001 mg/ml in oils isolated from samples from Alcanena and Duas Igrejas, respectively. The oils isolated from T. zygis subsp....
Tipo: Article Palavras-chave: Thymus; Lamiaceae; Labiatae; Antioxidant activity; Essential oils.
Ano: 2010 URL: http://hdl.handle.net/10198/4474
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CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations Biol. Res.
Takahashi,Hiroshi; Ikeda,Kazuhiko; Ogawa,Kazuei; Saito,Syunnichi; Ngoma,Alain M; Mashimo,Yumiko; Ueda,Koki; Furukawa,Miki; Shichishima-Nakamura,Akiko; Ohkawara,Hiroshi; Nollet,Kenneth E; Ohto,Hitoshi; Takeishi,Yasuchika.
BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher...
Tipo: Journal article Palavras-chave: Regulatory T cells; Allogeneic hematopoietic stem cell transplantation; Thymus; Graft-versus-host disease.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041
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Cellular and matrix interactions during the development of T lymphocytes BJMBR
Owen,J.J.T.; McLoughlin,D.E.; Suniara,R.K.; Jenkinson,E.J..
The thymus contains an extensive extracellular matrix. Although thymocytes express integrins capable of binding to matrix molecules, the functional significance of the matrix for T cell development is uncertain. We have shown that the matrix is associated with thymic fibroblasts which are required for the CD44+ CD25+ stage of double negative (CD4-8-) thymocyte development. The survival of cells at this stage is dependent on IL-7 and we propose that the role of fibroblasts is to present, via the matrix, IL-7 to developing T cells.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Extracellular matrix; Epithelial cells; Fibroblasts; Integrins; Interleukin-7; Thymus.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500008
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Distribution and Morphology of Ghrelin-Immunopositive Cells in the Thymus of the African Ostrich International Journal of Morphology
Wang,Jia-xiang; Li,Peng; Zhang,Xiao-ting; Ye,Li-xun.
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has been detected in the thymus of multiple vertebrates. However, little is known about its distribution in the thymus of the African ostrich. In this study, we evaluated the distribution and morphological characteristics of ghrelin-producing cells in the thymus of the African ostrich. Our results revealed that the thymus consists of a capsule and a parenchyma, which comprises the cortex and medulla. Compared to the cortex, the medulla had a fewer number of thymocytes and a greater number of epithelial cells. Additionally, three thymic corpuscles were identified. Ghrelin-immunopositive (ghrelin-ip) cells were detected both in the cortex and medulla of the African ostrich thymus,...
Tipo: Journal article Palavras-chave: African ostrich; Ghrelin; Thymus; Immunohistochemistry.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200026
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Effect of protein malnutrition on the glycolytic and glutaminolytic enzyme activity of rat thymus and mesenteric lymph nodes BJMBR
The activity of important glycolytic enzymes (hexokinase, phosphofructokinase, aldolase, phosphohexoseisomerase, pyruvate kinase and lactate dehydrogenase) and glutaminolytic enzymes (phosphate-dependent glutaminase) was determined in the thymus and mesenteric lymph nodes of Wistar rats submitted to protein malnutrition (6% protein in the diet rather than 20%) from conception to 12 weeks after birth. The wet weight (g) of the thymus and mesenteric lymph nodes decreased due to protein malnutrition by 87% (from 0.30 ± 0.05 to 0.04 ± 0.01) and 75% (0.40 ± 0.04 to 0.10 ± 0.02), respectively. The protein content was reduced only in the thymus from 102.3 ± 4.4 (control rats) to 72.6 ± 6.6 (malnourished rats). The glycolytic enzymes were not affected by protein...
Palavras-chave: Protein malnutrition; Glucose metabolism; Glutamine metabolism; Thymus; Lymph nodes.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000600003
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Effects of Gaba on the Thymus Cytokines of Wenchang Chickens Submitted to Heat Stress Rev. Bras. Ciênc. Avic.
Xie,XZ; Liang,C; Li,MH; Chen,Z.
ABSTRACT Under routine feeding conditions, 1-day-old male chicks were randomly divided into control group (CK), heat-stress group (HS), and GABA + heat stress group (GABA+HS). The thymus contents of IL-1, IL-2, TGF-β1, IFN-γ, GH and HSP70 were determined by enzyme-linked immunosorbent assays. The results showed that: (1) IL-1 and TGF-β1 contents of HS group were significantly lower than those of the CK group (p<0.05), and those of the GABA+HS group were significantly higher relative to the HS group (p<0.05); (2) IL-2 and IFN-γ contents of the HS group were significantly higher than those of the CK group (p<0.05), and those of the GABA+HS group were significantly lower relative to the HS group (p<0.05);(3) the thymus GH content of all three...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heat stress; GABA; Cytokines; Thymus; Chicks.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000100143
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Fetal Central Nervous System and Thymic Alterations Following Cyclophosphamide Treatment of Pregnant Mice International Journal of Morphology
Prakash,; Singh,Gajendra; Singh,Sukh Mahendra.
The present study assessed central nervous system (CNS) and immune system changes in murine fetuses after cyclophosphamide (CP) exposure during intrauterine life. A single CP dose of 0, 10, or 20mg/kg body weight was administered by intraperitoneal inj ection to pregnant mice (20/group) on day 11 of gestation (GD 11) and fetuses were evaluated on day 19 of gestation (GD 19). Fetuses were examined for external changes, and then the brains and thymuses were removed for further evaluations of histological changes, protein content, apoptotic cell count, DNA fragmentation, and in vitro cell proliferation using 1 fetus/litter for each assessment. Brains and thymuses from CP-exposed fetuses were smaller in size and distorted in overall shape compared to those...
Tipo: Journal article Palavras-chave: Cyclophosphamide; Brain; Thymus; Mice; Teratology.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400016
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Gap junction modulation by extracellular signaling molecules: the thymus model BJMBR
Alves,L.A.; Nihei,O.K.; Fonseca,P.C.; Campos-de-Carvalho,A.C.; Savino,W..
Gap junctions are intercellular channels which connect adjacent cells and allow direct exchange of molecules of low molecular weight between them. Such a communication has been described as fundamental in many systems due to its importance in coordination, proliferation and differentiation. Recently, it has been shown that gap junctional intercellular communication (GJIC) can be modulated by several extracellular soluble factors such as classical hormones, neurotransmitters, interleukins, growth factors and some paracrine substances. Herein, we discuss some aspects of the general modulation of GJIC by extracellular messenger molecules and more particularly the regulation of such communication in the thymus gland. Additionally, we discuss recent data...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thymus; Thymic epithelial cells; Connexin 43; Hormones; Interleukins.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400012
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Morphometric analysis of the thymus of puppies infected with the Snyder Hill Strain of canine distemper virus Arq. Bras. Med. Vet. Zootec.
Alves,C.M.; Vasconcelos,A.C.; Martins,A.S.; del Puerto,H.L.; Santos,F.G.A.; Nunes,J.E.S.; Campos,P.P.; Moro,L..
The thymic morphometry analysis was used for determining apoptosis and atrophy of the thymus of eight puppies inoculated with canine distemper virus (CDV). Three healthy dogs were used as negative controls. Sections, 5µm thick, were stained by HE and Shorr, and the latter were evaluated by morphometry. CDV nucleoprotein was detected by immunohistochemistry. Morphometric results confirmed lymphoid hypotrophy in CDV inoculated dog thymuses, more stroma, less parenchyma and higher apoptotic index/field than negative control (not inoculated) puppies. Apoptosis plays a role in the mechanism of thymus atrophy that develops in canine distemper.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Puppy; Apoptosis; Thymus; Canine distemper; Immunology; Virus; Immunosuppression.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352006000400004
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The conveyor belt hypothesis for thymocyte migration: participation of adhesion and de-adhesion molecules BJMBR
Villa-Verde,D.M.S.; Calado,T.C.; Ocampo,J.S.P.; Silva-Monteiro,E.; Savino,W..
Thymocyte differentiation is the process by which bone marrow-derived precursors enter the thymus, proliferate, rearrange the genes and express the corresponding T cell receptors, and undergo positive and/or negative selection, ultimately yielding mature T cells that will represent the so-called T cell repertoire. This process occurs in the context of cell migration, whose cellular and molecular basis is still poorly understood. Kinetic studies favor the idea that these cells leave the organ in an ordered pattern, as if they were moving on a conveyor belt. We have recently proposed that extracellular matrix glycoproteins, such as fibronectin, laminin and type IV collagen, among others, produced by non-lymphoid cells both in the cortex and in the medulla,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thymus; Thymic nurse cells; Adhesion molecules; Extracellular matrix; Galectin-3.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500010
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Thymic atrophy and fungal virulence during experimental paracoccidioidomycosis BJM
Brito,Vânia Nieto; Souto,Paula Cristina de Souza; Gameiro,Jacy; Cruz-Höfling,Maria Alice; Verinaud,Liana.
The immunosuppression observed in systemic mycosis can be related to primary lymphoid organs damage. Thus, our laboratory has studied the effects of the Paracoccidioides brasiliensis infection on the thymus of mice. Here, thymuses of susceptible and resistant mice were evaluated after inoculation with highly and slightly virulent isolates of the fungus. All groups presented thymic atrophy, loss of corticomedullary delimitation and increase of apoptotic index. However, mice inoculated with high virulent strain showed earlier and stronger alterations suggesting that thymic atrophy can be directly related to the fungal virulence and to the immunosuppression.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioides brasiliensis; Thymus; Fungal virulence.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000500005
Registros recuperados: 11
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