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Active transcription and ultrastructural changes during Trypanosoma cruzi metacyclogenesis Anais da ABC (AABC)
Ferreira,Ludmila R.P.; Dossin,Fernando de M.; Ramos,Thiago C.; Freymüller,Edna; Schenkman,Sergio.
The differentiation of proliferating epimastigote forms of Trypanosoma cruzi , the protozoan parasite that causes Chagas’ disease, into the infective and non-proliferating metacyclic forms can be reproduced in the laboratory by incubating the cells in a chemically-defined medium that mimics the urine of the insect vector. Epimastigotes have a spherical nucleus, a flagellum protruding from the middle of the protozoan cell, and a disk-shaped kinetoplast - an organelle that corresponds to the mitochondrial DNA. Metacyclic trypomastigotes have an elongated shape with the flagellum protruding from the posterior portion of the cell and associated with a spherical kinetoplast. Here we describe the morphological events of this transformation and characterize a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Metacyclogenesis; Transcription; RNA polymerase II.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100011
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American trypanosomiasis and associated risk factors in owned dogs from the major city of Yucatan, Mexico J. Venom. Anim. Toxins incl. Trop. Dis.
Jiménez-Coello,Matilde; Acosta-Viana,Karla; Guzmán-Marín,Eugenia; Bárcenas-Irabién,Alejandra; Ortega-Pacheco,Antonio.
AbstractBackground The American trypanosomiasis is a zoonosis caused by the protozoaTrypanosoma cruzi (T. cruzi). The disease is widely distributed throughout the American continent, affecting a wide range of hosts, including dogs. It is present in the canine population in the State of Yucatan, Mexico. However, no significant studies in owned dogs have been performed in the metropolitan area of Merida. A transversal study was conducted in 370 owned dogs from Merida, Yucatan, Mexico.Methods A cross-sectional study including 370 dogs was performed in a major city of Yucatan, Mexico, to detect IgG antibodies against T. cruzi. A commercial ELISA test kit was used and a chi-square test used to evaluate associated risk factors; odds ratio (OR) and 95 %...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Epidemiology; Owned dogs; Major city; Mexico.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100343
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Antileishmanial and antitrypanosomal activity of the cutaneous secretion of Siphonops annulatus J. Venom. Anim. Toxins incl. Trop. Dis.
Pinto,Erika Gracielle; Antoniazzi,Marta Maria; Jared,Carlos; Tempone,and Andre Gustavo.
Background Among the tropical parasitic diseases, those caused by protozoans are considered a challenge to public health, being represented by leishmaniasis and Chagas disease. In view of the low effectiveness and toxicity of the current therapy, animal venoms such as amphibian secretions have been used as a promising source of new drug prototypes. The present work aimed to achieve bioguided fractionation of metabolites present in a cutaneous secretion of the caecilian Siphonops annulatus (Amphibia: Gymnophiona: Siphonopidae) with antileishmanial and antitrypanosomal activity.Methods Through liquid-liquid partition and chromatographic techniques, the secretion was fractionated using bioguided assays. The 50% inhibitory concentration (IC50) of the main...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amphibians; Venoms; Leishmania; Trypanosoma cruzi; Therapy; Drugs.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200340
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Anti-Trypanosoma cruzi antibody detection in blood donors in the Southern Brazil BJID
Araújo,A.B.; Vianna,E.E.S.; Berne,M.E.A..
Trypanosoma cruzi, the causal agent of Chagas' Disease, is a widely spread protozoa in America. Blood transfusion is the secondly most important way of acquiring the infection. In blood banks, tests are performed to eliminate potentially infected blood. This study aimed to evaluate the positivity for T. cruzi in blood samples of donor's candidates in Southern Brazil. The study was based on a sampling containing all blood donors of Hemopel - a Pelotas City Blood Center, Rio Grande do Sul State, Brazil, from 2004 to 2005. Serological study was performed using ELISA Chagatest. Sampling containing values ± 20% cut off were evaluated using ELISA Chagatek, ELISA Alka/Adaltis, IHA Chagatest and IIF Imunocruzi. TESA-Blot was used as a confirmatory procedure in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Blood donors; Serological screening.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600007
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Aspectos clínico-laboratoriais da infecção natural por Trypanosoma cruzi em cães de Mato Grosso do Sul Ciência Rural
Souza,Alda Izabel de; Paulino-Junior,Daniel; Sousa,Marlos Gonçalves; Camacho,Aparecido Antonio.
A doença de Chagas causada pelo T. cruzi é transmitida, principalmente, por insetos vetores e está distribuída na Argentina, no Chile, na Venezuela e no Brasil. O cão, além de ser um importante reservatório, também é vítima da doença e a única espécie capaz de desenvolver manifestações clínicas iguais a do homem. O presente trabalho teve como objetivo descrever as alterações clínicas encontradas em quatro cães infectados naturalmente pelo T. cruzi e alertar para a possibilidade de que a ocorrência dessa enfermidade em cães de Mato Grosso do Sul possa estar sendo subestimada. Os animais foram selecionados a partir de exames sorológicos de reação de imunofluorescência indireta (RIFI), ensaio imunossorvente ligado à enzima (ELISA) e immunoblotting com...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Doença de Chagas; Trypanosoma cruzi; Cão; Aspectos clínicos.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782008000500024
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Avaliação da atividade anti-Leishmania e anti-Trypanosoma do extrato etanólico das folhas de Annona squamosa L Acta Toxicol. Argent.
Sobreira Dantas Nóbrega de Figuêiredo,Francisco Rodolpho; Gyllyandeson,de Araújo Delmondes; Paulo da Cruz,Luzia; Amaro do Nascimento,Érika; Relison Tintino,Saulo; Santiago Lemos,Izabel Cristina; Bezerra da Cunha,Francisco Assis; Vega Gomez,Maria Celeste; Coronel,Cathia; Martins da Costa,José Galberto; Melo Coutinho,Henrique Douglas; Bezerra Felipe,Cícero Francisco; Alencar de Menezes,Irwin Rose; Kerntopf,Marta Regina.
As doenças parasitárias, também chamadas de “doenças negligenciadas”, continuam sendo uma grande dificuldade para o desenvolvimento social e econômico dos países mais pobres. Podemos citar como exemplo dessas doenças, a leishmaniose e a doença de Chagas. A leishmaniose é causada por parasitas do gênero Leishmania e afeta cerca de 12 milhões de pessoas. A doença de Chagas, causada pelo protozoário Trypanosoma cruzi, causa aproximadamente 50.000 mortes por ano. Os fármacos disponíveis para o tratamento dessas doenças são altamente tóxicos, sendo este um dos motivos que leva à busca por drogas eficazes e seguras para seus tratamentos. As folhas da Annona squamosa, espécie da família Annonaceae, já foram descritas na literatura por suas...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Annona squamosa; Annonaceae; Leishmania; Trypanosoma cruzi.
Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432016000300001
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Avaliação da atividade de extratos de Talinum triangulare e Sphagneticola trilobata sobre Trypanosoma cruzi. Repositório Alice
CRUZ, E. M.; AMORIM, A. P. O.; OLIVEIRA, M. C. de S.; CARVALHO, M. G.; SANTOS, M. A. V..
O Trypanosoma cruzi, agente etiológico da doença de Chagas, atinge cerca de 18 milhões de pessoas na América Latina. Os fármacos utilizados para o tratamento geralmente são ineficazes e apresentam severos efeitos colaterais, tornando a busca por novos tratamentos bastante pertinente. Vários trabalhos têm mostrado os efeitos de extratos de plantas contra T. cruzi. As espécies vegetais Talinum triangulare (Portulacaceae) e Sphagneticola trilobata (Asteraceae) conhecidas popularmente no Brasil como caruru do Pará e vedélia, respectivamente, classificadas como invasoras, são mais resistentes ao ataque de pragas, despertando assim o interesse farmacológico. Assim, este trabalho avaliou os efeitos de extratos de T. triangulare e S. trilobata em culturas de T....
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Extratos de talinum triangulare; Trypanosoma cruzi; Sphagneticola trilobata.
Ano: 2009 URL: http://www.alice.cnptia.embrapa.br/handle/doc/574897
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Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi Anais da ABC (AABC)
Soares,Milena B. P.; Gonçalves,Renata; Pyrrho,Alexandre S.; Costa,Deise A.; Paiva,Claudia N.; Gattass,Cerli R..
We have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-<FONT FACE=Symbol>g</font> and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Protection; Cytokines; Humoral response.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000200005
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Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection J. Venom. Anim. Toxins incl. Trop. Dis.
Gatto,Mariana; Oliveira,Larissa Ragozo Cardoso; Dias,Fernanda De Nuzzi; Araújo Júnior,João Pessoa; Lima,Carlos Roberto Gonçalves; Lordelo,Eliana Peresi; Santos,Rodrigo Mattos dos; Kurokawa,Cilmery Suemi.
Abstract Background The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental infection with Trypanosoma cruzi, strains JLP or Y. Methods The mRNA expression of cytokines and parasite load were assessed by q-PCR. Dependent groups were compared using Student's paired t-test and independent groups were compared using Student's unpaired t-test. Results Infection with the JLP or Y strains increased expression of IFN-γ in the heart and of IL-10 and IL-17 in the spleen and heart compared to uninfected animals. Treatment increased the expression of IFN-γ and decreased the expression of IL-17, IL-10, TGF- β and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Trypanosoma cruzi; Immune response; Cytokines; Q-PCR.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100320
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Biological activity of the essential oils from Cinnamodendron dinisii and Siparuna guianensis BJM
Andrade,Milene Aparecida; Cardoso,Maria das Graças; Gomes,Marcos de Souza; Azeredo,Camila Maria Oliveira de; Batista,Luís Roberto; Soares,Maurilio José; Rodrigues,Leonardo Milani Avelar; Figueiredo,Ana Cristina S..
This study had analyzed the antibacterial, antifungal and trypanocidal activity of the essential oils from Cinnamodendron dinisii Schwacke (Canellaceae) and Siparuna guianensis Aublet (Siparunaceae). The essential oils were obtained from fresh leaves by hydrodistillation, using a modified Clevenger apparatus. Chemical analysis by gas-liquid chromatography coupled to mass spectrometry (GC-MS) showed that these essential oils are rich in monoterpene and sesquiterpene hydrocarbons. Activity against the pathogenic bacteria Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, Salmonella choleraesuis and Staphylococcus aureus was evaluated with the agar cavity diffusion method, while activity on the filamentous fungi Aspergillus flavus, Aspergillus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Volatile oils; Fungi; Bacteria; Trypanosoma cruzi.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100189
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Canine trypanosomiasis: etiology of infection and implications for public health J. Venom. Anim. Toxins incl. Trop. Dis.
Eloy,LJ; Lucheis,SB.
Canine trypanosomiasis, caused by protozoans of the genus Trypanosoma, is divided into two primary types: the American form (Chagas disease), due to Trypanosoma cruzi infection, and the African form (sleeping sickness or surra), provoked by Trypanosomaevansi. This disease was originally enzootic and affected only wild animals, including mammals and birds, which served as reservoirs. Later, it spread to domestic animals such as horses, cattle and dogs. The disease became a zoonosis when contact between rural inhabitants and natural Trypanosoma foci occurred, due to ecological imbalances and increasing migration. Dogs are significantly involved in this context, because they are the main domestic animals and participate in the transmission and maintenance...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Canine trypanosomiasis; Trypanosoma cruzi; Trypanosoma evansi; Chagas disease; Surra.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000400002
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Chagas disease in prehistory Anais da ABC (AABC)
Ferreira,Luiz F.; Jansen,Ana M.; Araújo,Adauto.
The classical hypothesis proposes that Chagas disease has been originated in the Andean region among prehistoric people when they started domesticating animals, changing to sedentary habits, and adopting agriculture. These changes in their way of life happened nearly 6,000 years ago. However, paleoparasitological data based on molecular tools showed that Trypanosoma cruzi infection and Chagas disease were commonly found both in South and North American prehistoric populations long before that time, suggesting that Chagas disease may be as old as the human presence in the American continent. The study of the origin and dispersion of Trypanosoma cruzi infection among prehistoric human populations may help in the comprehension of the clinical and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ancient DNA; Chagas disease; Mummies; Paleoepideiology; Paleoparasitology; Trypanosoma cruzi.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000300022
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Chagas disease: Present status of pathogenic mechanisms and chemotherapy Biol. Res.
Maya,Juan Diego; Orellana,Myriam; Ferreira,Jorge; Kemmerling,Ulrike; López-Muñoz,Rodrigo; Morello,Antonio.
There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease, where 20%-30% of infected individuals develop severe cardiopathy, with heart failure and potentially fatal arrhythmias. Currently, Chagas disease treatment is more effective in the acute phase, but does not always produce complete parasite eradication during indeterminate and chronic phases. At present, only nifurtimox or benznidazole have been proven to be superior to new drugs being tested. Therefore, it is necessary to find alternative approaches to treatment of chronic Chagas. The current treatment...
Tipo: Journal article Palavras-chave: Chagas disease; Chemotherapy; Nifurtimox; Trypanosoma cruzi; Prostaglandins.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300009
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Characterization of the Fibronectin Binding Properties of Typanosoma cruzi Epimastigotes OAK
Cox, Dermot; Uga, Shoji; Motoyama, Yukio; Yoshida, Keizo.
Palavras-chave: Trypanosoma cruzi; Epimastigotes; Fibronectin binding; RGDS(Arg-Gly-Asp-Ser).
Ano: 1992 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/176
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Chemical composition, anti-Trypanosoma cruzi and cytotoxic activities of the essential oil from green fruits of Protium ovatum (BURSERACEAE) Rev. Bras. Frutic.
Estevam,Elisângela Barbosa Borges; Alves,Cássia Cristina Fernandes; Esperandim,Viviane Rodrigues; Cazal,Cristiane de Melo; Souza,Alex Fonseca; Miranda,Mayker Lazaro Dantas.
Abstract Chagas disease is a major neglected tropical disease caused by Trypanosoma cruzi. It has been treated with the antiparasitic drugs nifurtimox and benzonidazole, which cause several side effects. The market for natural products has considerably grown lately and the use of plants has become an alternative to the development of novel drugs to cure the disease. Therefore, this study aimed at describing the chemical analysis of the essential oil from green fruits of Protium ovatum and evaluating their trypanocidal and cytotoxic potential. The essential oil was obtained by Clevenger hydrodistillation whereas its chemical composition was determined by gas chromatography coupled to mass spectrometry (GC-MS). The major compounds found in the essential oil...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Protium ovatum; SS-myrcene; Fruits; Essential oil; Trypanosoma cruzi; Cytotoxic analysis.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-29452018000106001
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Chronic Chagas disease: PCR-xenodiagnosis without previous microscopic observation is a useful tool to detect viable Trypanosoma cruzi Biol. Res.
Saavedra,Miguel; Zulantay,Inés; Apt,Werner; Martínez,Gabriela; Rojas,Antonio; Rodríguez,Jorge.
We evaluate the elimination of the microscopic stage of conventional xenodiagnosis (XD) to optimize the parasitological diagnosis of Trypanosoma cruzi in chronic Chagas disease. To this purpose we applied under informed consent two XD cages to 150 Chilean chronic chagasic patients. The fecal samples (FS) of the triatomines at 30, 60 and 90 days post feeding were divided into two parts: in one a microscopic search for mobile trypomastigote and/or epimastigote forms was performed. In the other part, DNA extraction-purification for PCR directed to the conserved region of kDNA minicircles of trypanosomes (PCR-XD), without previous microscopic observation was done. An XD was considered positive when at least one mobile T. cruzi parasite in any one of three...
Tipo: Journal article Palavras-chave: Chronic Chagas disease; PCR; Triatoma infestans; Trypanosoma cruzi; Xenodiagnosis.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300011
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Cissampelos sympodialis Eichl (Menispermaceae) leaf extract induces interleukin-10-dependent inhibition of Trypanosoma cruzi killing by macrophages BJMBR
Alexandre-Moreira,M.S.; Freire-de-Lima,C.G.; Trindade,M.N.; Castro-Faria-Neto,H.C.; Piuvezam,M.R.; Peçanha,L.M.T..
The aqueous fraction of the ethanolic extract (AFL) of Cissampelos sympodialis Eichl (Menispermaceae), popularly known as milona, has been shown to have both immunosuppressive and anti-inflammatory effects. In the present study we investigated the modulation of macrophage antimicrobicidal activity by in vitro treatment with the extract from C. sympodialis. Normal and thioglycolate-elicited mouse peritoneal macrophages were infected in vitro with the protozoan Trypanosoma cruzi DM28c clone. We observed that the AFL (used at doses ranging from 13 to 100 µg/ml) increased T. cruzi growth and induced a 75% reduction in nitric oxide production. This inhibition could be mediated by the stimulation of macrophage interleukin-10 (IL-10) secretion since the in vitro...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cissampelos sympodialis; Macrophage; Trypanosoma cruzi; Nitric oxide; Interleukin-10.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200006
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Clearance-inducing antibodies are responsible for protection against the acute phase of Trypanosoma cruzi infection in mice BJMBR
Umekita,L.F.; Ramos,D.P.; Mota,I..
A study was conducted on mice infected with strains Y and CL of Trypanosoma cruzi. The ability of anti-Y and anti-CL sera to induce complement-mediated lysis, immune clearance and protection against the acute phase of the infection was studied using homologous anti-Y or anti-CL serum tested with the Y or CL strain, or heterologous anti-Y serum tested with the CL strain or anti-CL serum tested with the Y strain. Complement-mediated lysis was induced by both homologous and heterologous antisera but protection was afforded only by homologous antisera. Immune clearance was induced by homologous but not by heterologous antisera. Antisera with high clearance ability were able to confer protection whereas antisera with high lytic ability were not. These results...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Clearance; Complement-mediated lysis; Protection.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000009
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Complexity and multi-factoriality of Trypanosoma cruzi sylvatic cycle in coatis, Nasua nasua (Procyonidae), and triatomine bugs in the Brazilian Pantanal. Repositório Alice
ALVES, F. M.; LIMA, J. S.; ROCHA, F. L.; HERRERA, H. M.; MOURAO, G.; JANSEN, A. M..
Trypanosoma cruzi is dispersed in nature through many transmission mechanisms among a high diversity of vectors and mammalian species, representing particular behaviors and habitats. Thus, each locality has a unique set of conditions underlying the maintenance of this parasite in the wild. The aim of the present study was to evaluate the life-cycle of T. cruzi in free-ranging coatis from the central region of the Brazilian Pantanal using a multi-factorial approach. Three methodological blocks were used in the present study: (i) We evaluated T. cruzi infection using serological (ELISA) and parasitological (hemoculture) tests in free-ranging coatis captured from October 2010 to March 2012. In addition, we characterized T. cruzi isolates as DTUs (Discrete...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Nasua nasua; Triatoma; Sylvatic cycle; Doença animal; Vetor; Trypanosoma cruzi; Rhodnius; Disease vectors.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1048499
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Conventional serological performance in diagnosis of Chagas' disease in southern Brazil BJID
Araújo,Anelise Bergmann; Berne,Maria Elisabeth Aires.
Results of Chagas' disease diagnosis show disagreement. The aim of this study was to compare commercial tests for Chagas' disease serodiagnosis in southern Brazil. A total of 161 samples were evaluated. Three enzyme-linked immunosorbent assays, one indirect hemagglutination and one indirect immunofluorescence were assessed. Trypomastigote excreted-secreted antigen-blot was a confirmatory method. From 161 samples, 65.84% were positive in all tests, while 34.16% presents mismatch result in at least one of the tests. All techniques tested presented false-positive and/or false-negative results as follows: Enzyme-linked immunosorbent assay 1 had more false-positive results (lower specificity), indirect immunofluorescence had the highest rate of false-negative...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Chagas' disease; Serodiagnosis; Immunoassays.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200010
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