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Development and validation of highly selective method for the determination of imatinib mesylate and dexketoprofen trometamol combination in three different media BJPS
Coban,Ozlem; Degim,Zelihagul.
Imatinib mesylate is a small molecule used in cancer therapy as a thyrosine kinase inhibitor. Dexketoprofen trometamol is a non-steroidal anti-inflammatory drug that has seen use in cancer therapy in combination with an anticancer drug to minimize tumor size and to reduce pain in patients. In the present study, imatinib mesylate and dexketoprofen trometamol were selected as potential model drugs to be used in combination. A new, simple and selective Ultra Performance Liquid Chromatography method was developed and validated to determine the drug substances in distilled water, in a pH 7.4 phosphate buffer and in Dulbecco’s Modified Eagle Medium. The proposed method was developed using a BEH C-18 column with isocratic elution. A mixture of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Imatinib mesylate; Dexketoprofen trometamol; Ultra Performance Liquid Chromatography; Dulbecco’s Modified Eagle Medium.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100575
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