Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados 60 (2) Autor AnjiReddy,Keshireddy (1) Bhalekar,Mangesh Ramesh (1) Gambhire,Makarand Suresh (1) Gambhire,Vaishali Makarand (1) Karpagam,Subramanian (1) Palavra-chave Ultrasonication (2) 3D atomic force microscopy (1) 3² factorial design (1) Alzheimer’s disease (1) Dithranol (1) Donepezil (1) Homogenization (1) Nanocrystalline cellulose (1) Oral dispersible film (1) Solid lipid nanoparticles (1) Solvent casting (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Micro and nanocrystalline cellulose based oral dispersible film; preparation and evaluation of in vitro/in vivo rapid release studies for donepezil 60 AnjiReddy,Keshireddy; Karpagam,Subramanian. Oral fast-dispersible film was prepared by utlizing donepezil hydrochloride (drug) and various cellulose derivatives such as hydroxypropyl methyl cellulose (hypermellose) (HPMC), microcrystalline cellulose (MCC) and nanocrystalline cellulose (NCC) to treat Alzheimer’s disease. NCC was synthesized by ultra-sonication method using MCC and this was converted to thinfilm formulation (NCC-F) using solvent casting technique. The interaction between the polymer and the drug was investigated by spectral analysis such as UV, FTIR, and 1H- NMR. FTIR confirmed that the compatibility of drug and polymer in ODF formulation. NCC-F has shown an average surface roughness of 77.04 nm from AFM and the average particle size of 300 nm from SEM analysis. Nano sized particle of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Oral dispersible film; Nanocrystalline cellulose; Ultrasonication; 3D atomic force microscopy; Donepezil; Solvent casting; Alzheimer’s disease. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100586 Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design 60 Gambhire,Makarand Suresh; Bhalekar,Mangesh Ramesh; Gambhire,Vaishali Makarand. This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factorial design to study the influence on the response variables particle size and % entrapment efficiency (%EE). From the statistical analysis of data polynomial equations were generated. The particle size and %EE for the 9 batches (R1 to R9) showed a wide variation of 219-348 nm and 51.33- 71.80 %, respectively. The physical characteristics of DTH-loaded SLN were evaluated using a particle size analyzer, differential scanning calorimetry and X-ray diffraction. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solid lipid nanoparticles; Homogenization; Ultrasonication; 3² factorial design; Dithranol. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300008 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco