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| Registros recuperados: 21 | |
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| Gunasekaran,B.; Gothandam,K.M.. |
| For a long time, vaccines have been the main mode of defense and protection against several bacterial, viral, and parasitic diseases. However, the process of production and purification makes them expensive and unaffordable to many developing nations. An edible vaccine is when the antigen is expressed in the edible part of the plant. This reduces the cost of production of the vaccine because of ease of culturing. In this article, various types of edible vaccines that include algal and probiotics in addition to plants are discussed. Various diseases against which research has been carried out are also reviewed. This article focused on the conception of edible vaccines highlighting the various ways by which vaccines can be delivered. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vaccines; Plants; Algae; Probiotics; Edible vaccine. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000200301 |
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| Gomes,P.A.D.P.; Bentancor,L.V.; Paccez,J.D.; Sbrogio-Almeida,M.E.; Palermo,M. S.; Ferreira,R.C.C.; Ferreira,L.C.S.. |
| No effective vaccine or immunotherapy is presently available for patients with the hemolytic uremic syndrome (HUS) induced by Shiga-like toxin (Stx) producedbyenterohaemorragic Escherichia coli (EHEC) strains, such as those belonging to the O157:H7 serotype. In this work we evaluated the performance of Bacillus subtilis strains, a harmless spore former gram-positive bacterium species, as a vaccine vehicle for the expression of Stx2B subunit (Stx2B). A recombinant B. subtilis vaccine strain expressing Stx2B under the control of a stress inducible promoter was delivered to BALB/c mice via oral, nasal or subcutaneous routes using both vegetative cells and spores. Mice immunized with vegetative cells by the oral route developed low but specific anti-Stx2B... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: EHEC; Stx; Bacillus subtilis; Vaccines; HUS. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000200023 |
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| Braga,Catarina J.M.; Massis,Liliana M.; Alencar,Bruna C.G.; Rodrigues,Maurício M.; Sbrogio-Almeida,M.E.; Ferreira,Luís C.S.. |
| Bacterial flagellins are important virulence-associated factors and strong inducers of inflammatory responses in mammalian hosts. Flagellins have also been investigated as potential vaccine adjuvants, either for induction of humoral or cellular immune responses, to different target antigens. In this study we investigated the adjuvant properties of three Salmonella enterica flagellins types (FliCd, FliCi and FljB) to an ovalbumin-derived CD8+ T cell-restricted epitope (OVA257264). Although mice immunized with the three tested flagellins elicited antigen-specific activated CD8+ T cells, only animals immunized with FliCi and FliCd flagellins admixed with ovalbumin mounted specific in vivo cytotoxic responses to peptide-pulsed target cells. The present results... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Salmonella; Flagellin; Cytotoxic T cells; Adjuvants; Vaccines. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000100011 |
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| Almeida,Hugo; Amaral,Maria Helena; Lobão,Paulo. |
| In recent years, the number of drugs of biotechnological origin available for many different diseases has increased exponentially, including different types of cancer, diabetes mellitus, infectious diseases (e.g. AIDS Virus / HIV) as well as cardiovascular, neurological, respiratory, and autoimmune diseases, among others. The pharmaceutical industry has used different technologies to obtain new and promising active ingredients, as exemplified by the fermentation technique, recombinant DNA technique and the hybridoma technique. The expiry of the patents of the first drugs of biotechnological origin and the consequent emergence of biosimilar products, have posed various questions to health authorities worldwide regarding the definition, framework, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biotechnology; Recombinant DNA; Hybridoma technique; Bacteria; Antibiotics; Vaccines. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200002 |
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| Rubin,LL; Canal,CW; Ribeiro,ALM; Kessler,A; Silva,I; Trevizan,L; Viola,T; Raber,M; Gonçalves,TA; Krás,R. |
| The present study aimed at assessing the effects of methionine and arginine on the immune response of broiler chickens submitted to immunological stimuli. Three methionine concentrations (0.31, 0.51, and 0.66% from 1 to 21 days of age; 0.29, 0.49, and 0.64% from 22 to 42 days of age) and 2 arginine concentrations (1.33 and 1.83%; 1.14 and 1.64% for the same life periods) were tested. Birds were divided into two groups for immunological stimuli (3x2x2 arrangement). Vaccines against Marek's disease, fowl pox, infectious bronchitis, Freund's Complete Adjuvant, Sheep red blood cells (SRBC), and avian tuberculin were administered to one group as immunological stimuli; the other group did not receive any stimulus. The experiment was carried out with 432... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amino acids; Birds; Immune system; Vaccines. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2007000400006 |
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| Leal,Elida A.; Moreira,Josimar D.; Nunes,Fernanda F.; Souza,Larissa R.; Martins,Janaina M.; Toledo,Vicente P.C.; Almeida,Alzira M.P.; Guimarães,Tania M.P.. |
| ABSTRACT Objectives: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response. Methods: The immunogenicity of antigenic preparations based on the Y. pestis (YP) total extract and the Y. pestis fraction 1 capsular antigen protein (F1) was determined in Swiss-Webster mice immunized with 40 µg or 20 µg for each... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Yersinia pestis; Antigens; Mice; Immune response; Vaccines. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600620 |
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| Moraes,Carina Martins de; Silva,Mariana Sá e; Vargas,Agueda Palmira Castagna de; Nogueira,Carlos Eduardo Wayne; Leite,Fábio Pereira Leivas; Gil-Turnes,Carlos. |
| Horse Strangles appears frequently in animals vaccinated with commercial bacterins in Rio Grande do Sul, Brazil. Aiming to know the antigenic relationships of strains recovered from sick animals among them and with two vaccines profusely used in the state, bilateral cross reactivity indices (CRI) were estimated. In addition, the immunogenicity of vaccines prepared with field isolates and commercial vaccines was tested in mice. Antibody titers were measured by ELISA and expressed as seroconversions. Thirteen strains of Streptococcus equi subsp. equi, nine classified biochemically as typical and other four as atypical strains, were recovered from 35 sick horses belonging to 10 herds of Rio Grande do Sul, Brazil. The strains recovered from sick horses showed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Horse Strangles; Streptococcus equi subsp. equi; Cross reactivity indices; Vaccines. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000500024 |
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| Bracco Neto,Humberto; Colucci,Anete; Puccini,Rosana F.; Farhat,Calil K.. |
| OBJECTIVE: To evaluate the immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type b conjugate vaccine (PRP-T) in Brazilian infants. MATERIAL AND METHODS: A prospective and open clinical study, in which 110 infants were immunized with a three-dose primary vaccination regime at two, four and six months of age and with a single booster vaccination. Blood samples were drawn immediately before the first dose, one month after the third dose, at the time of the booster dose and one month after the booster to assess seropositivity and antibody geometric mean titers (GMTs) of antibodies for diphtheria, tetanus, hepatitis B, Haemophilus influenzae type b and for the three pertussis antigens: Pertussis Toxin (PT), Filamentous... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vaccines/immunology; Vaccines; Combined; Diphtheria-tetanus-acellular pertussis vaccines; Hepatitis B vaccines; Haemophilus vaccines. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500003 |
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| Moraes,HLS; Salle,CTP; Padilha,AP; Nascimento,VP; Souza,GF; Pereira,RA; Artencio,JO; Salle,FO. |
| Infectious Bursal Disease (IBD) is a chicken disease economically important for the poultry industry in function of the immune depression that it causes. Disease control is made with different vaccines and vaccination programs. In present work, the pathogenicity of 3 intermediate vaccines (I1, I2 and I3), 2 intermediate more pathogenic (IP1 and IP2) and 3 vaccines containing strong virus (F1, F2 and F3) was evaluated. Birds vaccinated with IP1, IP2, F1, F2 and F3 showed significantly lower bursa size in relation to control animals and animals vaccinated with I1, I2 and I3. On the other hand, vaccines I1 and I3 induced antibody titers higher than the control and lower than I2, IP1, IP2, F1, F2 and F3. Histological scores showed that vaccines I1, I2 and I3... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bursa of Fabricius; Infectious bursal disease; Pathogenicity; Vaccines. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2004000400009 |
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| Hidalgo,H. |
| Infectious laryngotracheitis (ILT) herpesvirus continues to cause outbreaks of respiratory disease in chickens world-wide. Sporadic cases of ILT occur in all classes of birds, including hobby/show/game chickens, broilers, heavy breeders, and commercial laying hens. These epornitics of ILT tend to occur where there are large populations of naïve, unvaccinated birds, i.e., in concentrated areas of broiler production. ILT virus can be transmitted through (a) chickens with acute upper respiratory tract disease, (b) latently infected "carrier" fowls, and (c) fomites and contaminated persons. Chicken flocks which are endemic infected with ILT virus occur only in some regions of countries or even in particular multiple-age production farms. In these cases... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biosecurity; Broiler breeders; ILT virus; Laryngotracheitis; Laying hens; Vaccines. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2003000300001 |
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| Cunha-Neto,E.. |
| The target of any immunization is to activate and expand lymphocyte clones with the desired recognition specificity and the necessary effector functions. In gene, recombinant and peptide vaccines, the immunogen is a single protein or a small assembly of epitopes from antigenic proteins. Since most immune responses against protein and peptide antigens are T-cell dependent, the molecular target of such vaccines is to generate at least 50-100 complexes between MHC molecule and the antigenic peptide per antigen-presenting cell, sensitizing a T cell population of appropriate clonal size and effector characteristics. Thus, the immunobiology of antigen recognition by T cells must be taken into account when designing new generation peptide- or gene-based vaccines.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vaccines; MHC; Antigen recognition; Antigen processing; T cells; Molecular evolution. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200008 |
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| Gonçalves,Ana Katherine; Cobucci,Ricardo Ney; Rodrigues,Hugo Marcus; Melo,Amanda Gosson de; Giraldo,Paulo César. |
| Recently, many studies have evaluated HPV vaccine safety and adverse effects. Two vaccine shave been recently evaluated in randomized controlled trials: the bivalent vaccine for HPV 16 and 18 (Cervarix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent vaccine for HPV 6, 11, 16, and 18 (Gardasil, Merck and Co., Inc., Whitehouse Station, NJ). We have performed a systematic review of all randomized controlled trials in which HPV vaccines were compared with placebo regarding safety, tolerability and adverse effects. Studies were searched up to March 2013 in the databases: Pubmed, Embase, Scielo and Cancerlit. Odds Ratios (OR) of most incident adverse effects were obtained. Twelve reports, involving 29,540 subjects, were included. In the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HPV; Vaccines; Adverse effects. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600651 |
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| SILVA, R. A. e; PIRAINE, R. E. A.; SANTOS JUNIOR, A. G. dos; CUNHA, R. C.; GONÇALVES, V. S.; SANTOS, F. D. S.; LEITE, F. P. L.. |
| Neospora caninum, parasito causador da neosporose, é conhecido mundialmente como um dos principais responsáveis por abortos em rebanhos bovinos, causando prejuízos econômicos à pecuária. As infecções e transmissões do parasito entre os animais são de difícil combate, assim, métodos de diagnóstico e controle devem ser aplicados para reduzir a disseminação do patógeno nas propriedades. A vacinação de rebanhos seria uma alternativa para o controle, contudo, a falta de uma vacina segura e eficaz impede a aplicação deste método de controle. O parasito possui importantes proteínas estruturais que auxiliam no processo de infecção como proteínas de superfície, proteínas dos micronemas, antígenos dos grânulos densos e proteínas das róptrias. Antígenos dessas... |
| Tipo: Folhetos |
Palavras-chave: Imunógeno; Perspectiva; Look out; Vacina de DNA; Vacina viva; Proteína do micronema; Proteína de superfície; Neosporose; Antígeno; Vacina; Aborto; Neospora Caninum; Parasito de animal; Neosporosis; Antigens; Vaccines. |
| Ano: 2017 |
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1077355 |
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| Registros recuperados: 21 | |
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