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| Sukhorum,Wannisa; Sampannang,Apichakarn; Sripanidkulchai,Bungorn; Iamsaard,Sitthichai. |
| This study aimed to investigate protective effect of Momordica cochinchinensis (MC) aril extract on adverse reproductive parameters of male rat induced with valproic acid (VPA) commonly used in treatment for antiepileptic diseases. Male Wistar rats were divided into 6 groups (control, VPA, 200 mg/kg BW of PE only, and 50, 100, 200 mg/kg BW MC+VPA, respectively). Animals were pretreated with aqueous MC extract for 23 days before co-administered with VPA induction for 10 days. At the end of experiment, all male reproductive parameters and testicular histology were examined. The results showed all doses of PE significantly protect the decrease the weights of epididymis and seminal vesicle but not of body and testicular weights. MC extract also increased sperm... |
| Tipo: Journal article |
Palavras-chave: Momordica cochinchinensis; Valproic acid; Male reproductive parameters; Testicular damage; Rats. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300009 |
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| Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Sala,Miguel A; Mattos,Maria G. C. |
| Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Rat; Meckel's cartilage; Lingual musculature; Submandibular gland. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006 |
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| Iamsaard,Sitthichai; Arun,Supatcharee; Burawat,Jaturon; Sukhorum,Wannisa; Boonruangsri,Porntip; Namking,Malivalaya; Uabundit,Nongnut; Nualkaew,Somsak; Sripanidkulchai,Bungorn. |
| Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Phyllanthus emblica L; Testicular damage; Rats. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300033 |
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| Sitthichai,Iamsaard; Wannisa,Sukhorum; Apichakarn,Sampannang; Bungorn,Sripanidkulchai. |
| Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before co-administration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and... |
| Tipo: Journal article |
Palavras-chave: Androgen receptor (AR); Ki-67; Momordica cochinchinensis; Rats; Steroidogenic acute regulatory protein (StAR); Tyrosine testicular phosphorylated protein; Valproic acid. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300030 |
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| Aluclu,Mehmet Ufuk; Tuncer,Mehmet Cudi; Guzel,Aslan; Aluclu,Mustafa Arif; Akkus,Murat. |
| We aimed to investigate the potential harmful effects of maternal valproic acid (VPA) on fetal sciatic nerve, and the protective effects of vitamin E (Vit E) and folic acid (FA) on fetal rats. Valproic acid (400mg/kg), folic acid (400mg/kg) and vitamin E (250 mg/kg) were administered to rats on each of gestation days 8-10. All fetuses were collected on gestation day 20. With thin sections of biopsies, sciatic nerve of fetuses were stained with uranyl acetat and were examined under transmission electron microscope. The fetuses (n:36) were divided into five groups: control, vpa, vpa+fa, vpa+vit e and vpa+fa+vit e groups. In each group; drug procedure, surgical procedure and histological methods were performed. Later, weights and lengths of fetuses in each... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Sciatic nerve; Folic acid; Vitamin E; Rat. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000200001 |
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| Pamukcu Baran,Ozlem; Tunik,Selcuk; Akkoc,Hasan; Devieci,Engin; Ayaz,Ercan; Soker,Sevda; Kalkanli Tas,Sevgi; Akkus,Murat. |
| To evaluate histopathologic differences in the thymus of Wistar Albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit-E). VPA (400 mg/kg), FA (400 mcg/kg) and Vit -E (250 mg/kg) were administered to rats on each of gestation days 8, 9 and 10. The fetuses (n:24) were divided into four groups: control, VPA, VPA+Vit-E and VPA+FA groups. On the 20th day of gestation, all pregnant rats were sacrificed and the fetuses were extracted. Thin sections from thymus of live fetuses were stained with uranyl acetate-lead citrate and were examined under transmission electron microscope. The histopathological findings of control group was normal. In VPA group, it showed extensive degenerative changes by VPA were on all tissue... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Fetal thymus; Vitamin E; Folic acid. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400003 |
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