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Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats BJMBR
Cabral,A.M.; Silva,I.F.; Gardioli,C.R.; Mauad,H.; Vasquez,E.C..
Cardiac hypertrophy that accompanies hypertension seems to be a phenomenon of multifactorial origin whose development does not seem to depend on an increased pressure load alone, but also on local growth factors and cardioadrenergic activity. The aim of the present study was to determine if sympathetic renal denervation and its effects on arterial pressure level can prevent cardiac hypertrophy and if it can also delay the onset and attenuate the severity of deoxycorticosterone acetate (DOCA)-salt hypertension. DOCA-salt treatment was initiated in rats seven days after uninephrectomy and contralateral renal denervation or sham renal denervation. DOCA (15 mg/kg, sc) or vehicle (soybean oil, 0.25 ml per animal) was administered twice a week for two weeks....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ventricular hypertrophy; Renal denervation; DOCA-salt hypertension; Blood pressure.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400018
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Experimental myocardial hypertrophy induced by a minimally invasive ascending aorta coarctation BJMBR
Martins,A.S.; Aguilera,N.W.; Matsubara,B.B.; Bregagnollo,E.A..
Ascending aorta coarctation was produced by a minimally invasive technique in rabbits. Animal mortality was 5%. Morphometric and hemodynamic parameters were evaluated. A parabiotically isolated heart model was used to assess the hemodynamic parameters. Left ventricular weight/body weight ratio and muscle area showed clear evidence of hypertrophy when compared to control. The hemodynamic changes in the isolated heart model suggested decreased diastolic and systolic function in the coarcted group. The present model produced hypertrophy with low mortality rates as a result of its less invasive nature.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Ventricular hypertrophy; Ventricular function; Experimental model.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300017
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