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Registros recuperados: 12
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Hiding in plain sight: an evolutionary approach to the South American Zika outbreak and its future consequences Rev. Bras. Zool.
Apari,Péter; Bajer,Katalin; Brooks,Daniel R.; Molnár,Orsolya.
ABSTRACT Emerging Infectious Diseases (EID) pose a world-wide health and socio-economic threat. Accelerating climate change and globalization are exposing unforeseen ways that pathogens cope with their surroundings. The 2015 Zika virus (ZIKV) outbreak was an example of expansion into previously inaccessible fitness spaces, causing a sudden epidemic. Recent studies indicating the subsequent decrease in symptomatic cases means the virus is in remission, currently poses little threat, and therefore can be ignored. We present an evolutionary scenario derived from the Stockholm Paradigm, of oscillating phases of expansion and isolation, accompanied by changes in transmission, persistence, virulence, and pathology. Chief among these is the likelihood that...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Emerging Infectious Disease; Outbreaks; Stockholm Paradigm; Zika virus.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-46702019000100101
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Identification of Zika virus in immature phases of Aedes aegypti and Aedes albopictus: a surveillance strategy for outbreak anticipation BJMBR
Maniero,V.C.; Rangel,P.S.C.; Coelho,L.M.C.; Silva,C.S.B.; Aguiar,R.S.; Lamas,C.C.; Cardozo,S.V..
A progressive increase in the circulation of arboviruses in tropical countries has been observed, accounting for 700,000 yearly deaths in the world. The main objective of this article was to identify the presence of Zika (ZIKV), dengue (DENV), and Chikungunya (CHIKV) viruses in immature stages of Aedes aegypti and Ae. albopictus. Household collections of immature phases of the vectors were carried out in the years 2015 and 2016. A total of 2902 dwellings were visited and the rate of infestation with larvae and pupae of Aedes mosquitoes was 283/1462 (19.4%) in March 2015 and 55/1440 (3.8%) in June 2015. In March 2015, 907 larvae/pupae were collected (583 or 64.3% of Ae. aegypti and 324 or 35.7% of Ae. albopictus) while in June 2015 there was a reduction in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus; Aedes aegypti; Aedes albopictus; Arbovirus; Georeferencing; Xenomonitoring.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100605
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Low seroprevalence of Zika virus in Cameroonian blood donors BJID
Gake,Bouba; Vernet,Marie A.; Leparc-Goffart,Isabelle; Drexler,Jan Felix; Gould,Ernest A.; Gallian,Pierre; Lamballerie,Xavier de.
Abstract A Zika virus seroepidemiology study was performed in 1084 blood donors collected from August to October 2015 in six sites of Cameroon representing a large panel of eco-environments. Samples were tested using an anti-NS1 IgG ELISA detection kit and positives were further confirmed by seroneutralization. The observed global seroprevalence was low (around 5%, peaking at 10% and 7.7% in Douala and Bertoua, respectively) with risk factors associated with seropositivity pointing to the existence of a local (peri-)sylvatic cycle of transmission. These results call attention to the potential introduction and subsequent spread in African urban areas of Asian genotype Zika virus currently circulating in the Americas and adapted to transmission by...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Zika virus; Seroprevalence; Africa.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400481
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Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic BJMBR
Slavov,S.N.; Otaguiri,K.K.; Kashima,S.; Covas,D.T..
Zika virus (ZIKV), a mosquito-borne flavivirus, belongs to the Flaviviridae family, genus Flavivirus. ZIKV was initially isolated in 1947 from a sentinel monkey in the Zika forest, Uganda. Little clinical importance was attributed to ZIKV, once only few symptomatic cases were reported in some African and Southeast Asiatic countries. This situation changed in 2007, when a large outbreak was registered on the Yap Island, Micronesia, caused by the Asian ZIKV lineage. Between 2013 and 2014, ZIKV spread explosively and caused many outbreaks in different islands of the Southern Pacific Ocean and in 2015 autochthonous transmission was reported in Brazil. Currently, Brazil is the country with the highest number of ZIKV-positive cases in Latin America. Moreover,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus; ZIKV; Transmission; Epidemiology; Congenital infection; Brazil.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500201
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Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis BJID
Barbi,Ludovica; Coelho,Antonio Victor Campos; Alencar,Luiz Cláudio Arraes de; Crovella,Sergio.
ABSTRACT Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. GBS is a debilitating autoimmune disorder that affects peripheral nerves. Since ZIKV caused massive outbreaks in South America in the past few years, we aimed to systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individuals. We searched PubMed and Cochrane databases and selected three studies for a meta-analysis. We...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Arboviruses; Zika virus; Guillain-Barré syndrome; Epidemiology; Emergent diseases.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200137
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Searching for the best real-time RT-PCRs to detect Zika virus infections: the importance of comparing several protocols BJMBR
de Moraes,F.M.; Espósito,D.L.A.; Klein,T.M.; da Fonseca,B.A.L..
Clinical manifestations of Zika, dengue, and chikungunya virus infections are very similar, making it difficult to reach a diagnosis based only on clinical grounds. In addition, there is an intense cross-reactivity between antibodies directed to Zika virus and other flaviviruses, and an accurate Zika diagnosis is best achieved by real-time RT-PCR. However, some real-time RT-PCR show better performance than others. To reach the best possible Zika diagnosis, the analytic sensitivity of some probe-based real-time RT-PCR amplifying Zika virus RNA was evaluated in spiked and clinical samples. We evaluated primers and probes to detect Zika virus, which had been published before, and tested sensitivity using serum spiked and patient samples by real-time RT-PCR....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus; Flavivirus; Real time RT-PCR; Diagnosis.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600618
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Seroprevalence of Zika virus among blood donors before the epidemic in Barranquilla, Colombia, 2015-2016. Anais da ABC (AABC)
BAYONA-PACHECO,BRAYAN; ACOSTA-REYES,JORGE; NAVARRO,EDGAR; SAN-JUAN,HOMERO; BULA,JOHAN; BAQUERO,HERNANDO.
Abstract: The first cases of Zika virus infection in Colombia were reported and confirmed in October 2015. The objective of the study was estimate the seroprevalence of ZIKV infection during the pre-epidemic phase in Barranquilla, Colombia, and demonstrate the presence of virus before the Colombian Ministry of Health confirmed the first case. We conducted a descriptive study of the seroprevalence of Zika virus in 390 samples obtained from a blood bank located in Barranquilla, Colombia - a city endemic for dengue, and with a recent history of a Chikungunya disease epidemic. The serum pools were tested using Euroimmun ZIKV ELISA kit. Seroprevalence of Zika virus IgG were: May 2015: 0%, June and July 2015: 2.62% (95% CI = 0.28-12.13) and August 2015: 5.35%...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus; Seroprevalence; Pre-epidemic dates; Pregnant women.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500618
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Teratogens: a public health issue – a Brazilian overview Genet. Mol. Biol.
Mazzu-Nascimento,Thiago; Melo,Débora Gusmão; Morbioli,Giorgio Gianini; Carrilho,Emanuel; Vianna,Fernanda Sales Luiz; Silva,André Anjos da; Schuler-Faccini,Lavinia.
Abstract Congenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more frequently observed. Here, we address the environmental causes of birth defects – or teratogens – as a public health issue and present their mechanisms of action, categories and their respective maternal-fetal deleterious effects. We also present a survey from 2008 to 2013 of Brazilian cases involving congenital anomalies (annual average of 20,205), fetal deaths (annual average of 1,530), infant hospitalizations (annual average of 82,452), number of deaths of hospitalized infants (annual average of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Birth defects; Teratogens; Zika virus; Pregnancy; Public health.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300387
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Use of transgenic Aedes aegypti in Brazil: risk perception and assessment. Repositório Alice
ANDRADE, P. P. de; ARAGAO, F. J. L.; COLLI, W.; DELLAGOSTIN, O. A.; FINARDI-FILHO, F.; HIRATA, M. H.; LIRA-NETO, A. de C.; MELO, M. A. de; NEPOMUCENO, A. L.; NOBREGA, F. G. da; SOUSA, G. D. de; VALICENTE, F. H.; ZANETTINI, M. H. B..
The OX513A strain of Aedes aegypti, which was developed by the British company Oxitec, expresses a self-limiting transgene that prevents larvae from developing to adulthood. In April 2014, the Brazilian National Technical Commission on Biosafety completed a risk assessment of OX513A and concluded that the strain did not present new biological risks to humans or the environment and could be released in Brazil. At that point, Brazil became the first country to approve the unconstrained release of a genetically modified mosquito. During the assessment, the commission produced a comprehensive list of ? and systematically analysed ? the perceived hazards. Such hazards included the potential survival to adulthood of immature stages carrying the transgene ?...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Aedes transgênico; Método de controle; Mosquito geneticamente modificado; Chikungunya; Doença; Mosquito; Tetraciclina; Aedes aegypti; Zika virus; Dengue; Transgenes.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1055427
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Zika detection: comparison of methodologies BJM
Colombo,Tatiana Elias; Terzian,Ana Carolina Bernardes; Araújo Júnior,João Pessoa; Parreira,Ricardo; Cabrera,Eliana Márcia Sotello; Santos,Izalco Nuremberg Penha dos; Reis,Andréia Francesli Negri; Costa,Fabiana Rodrigues; Cruz,Lilian Elisa Arão Antônio; Rombola,Patrícia Lopes; Nogueira,Maurício Lacerda.
ABSTRACT Many countries in the Americas have detected local transmission of multiple arboviruses that cause febrile illnesses. Therefore, laboratory testing has become an important tool for confirming the etiology of these diseases. The present study aimed to compare the sensitivity and specificity of three different Zika virus detection assays. One hundred serum samples from patients presenting with acute febrile symptoms were tested using a previously reported TaqMan® RT-qPCR assay. We used a SYBR® Green RT-qPCR and a conventional PCR methodologies to compare the results. Of the samples that were determined to be negative by the TaqMan® RT-qPCR assay, 100% (Kappa = 0.670) were also found to be negative by SYBR® Green RT-qPCR based on Tm comparison;...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus; Detection; Sensitivity; Specificity.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000100144
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Zika virus congenital syndrome: experimental models and clinical aspects J. Venom. Anim. Toxins incl. Trop. Dis.
Polonio,Carolina Manganeli; Freitas,Carla Longo de; Zanluqui,Nagela Ghabdan; Peron,Jean Pierre Schatzmann.
Abstract Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC). ZIKV is an arbovirus of the Flaviviridae family firstly isolated from sentinels Rhesus sp. monkeys at the Ziika forest in Uganda, Africa, in 1947. Lately, the virus has well adapted...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus; Congenital infection; Arthrogryposis; Ocular abnormality; Experimental models.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100207
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Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data BJID
De Carvalho,Newton Sérgio; De Carvalho,Beatriz Freitas; Fugaça,Cyllian Arias; Dóris,Bruna; Biscaia,Evellyn Silverio.
Abstract In November of 2015, the Ministry of Health of Brazil published an announcement confirming the relationship between Zika virus and the microcephaly outbreak in the Northeast, suggesting that infected pregnant women might have transmitted the virus to their fetuses. The objectives of this study were to conduct a literature review about Zika virus infection and microcephaly, evaluate national and international epidemiological data, as well as the current recommendations for the health teams. Zika virus is an arbovirus, whose main vector is the Aedes sp. The main symptoms of the infection are maculopapular rash, fever, non-purulent conjunctivitis, and arthralgia. Transmission of this pathogen occurs mainly by mosquito bite, but there are also reports...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zika virus; Microcephaly; Aedes mosquitoes; Pregnancy.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300011
Registros recuperados: 12
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