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| Registros recuperados: 612 | |
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| Rakesh Sharma; Suniket Fulzele; Kiran Shetty; Mandeep Sachdeva; Bruce R. Locke. |
| *Aim:* A rapid ultra high resolution ex vivo MRI imaging method was evaluated to visualize rat skin structure. The main objectives were:1.qualitative assessment of viable epidermis, hair, oil and fat-rich skin features by multi-contrast approach;2.achievement of spatial resolution up to 15 microns; 3.comparison of skin histology with MRI skin features obtained by 21 Tesla magnetic resonance imaging (MRI) imager. 

*Introduction:* The ultrawide bore 900 MHz magnet has high resolution NMR magnet has a central field of 21.1 T. The high resolution MRI technique has potential for both quantitative and non-invasive morphological evaluation at micrometer level. The MRI signal was sensitive to water protons and glycolipid... |
| Tipo: Poster |
Palavras-chave: Biotechnology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2639/version/1 |
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| Rakesh Sharma. |
| Superparamagnetic iron-oxide bound antimyoglobin (SPIOM) characteristics were analyzed at different pH. After injecting SPIOM in heart, ex vivo magnetic resonance microimaging (MRM) technique was used to visualize microvasculature of rat heart including cardiac arteries, veins, cordate tendons attached with valves. The measurement accuracy of ventricles, aorta, vasculature and dimensions of cordate tendons were close to coregistered histology measurements. |
| Tipo: Poster |
Palavras-chave: Biotechnology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2643/version/1 |
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| Rakesh Sharma. |
| Superparamagnetic iron-oxide bound antimyoglobin (SPIOM) characteristics were analyzed at different pH. After injecting SPIOM in heart, ex vivo magnetic resonance microimaging (MRM) technique was used to visualize microvasculature of rat heart including cardiac arteries, veins, cordate tendons attached with valves. The measurement accuracy of ventricles, aorta, vasculature and dimensions of cordate tendons were close to coregistered histology measurements. |
| Tipo: Poster |
Palavras-chave: Biotechnology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2643/version/2 |
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| David Goldberg; Angela L. Slagle. |
| In recent years, the debate over the most effective means to stabilize greenhouse gas concentrations in the atmosphere has endorsed multiple approaches and a variety of technologies. Assuring secure storage of anthropogenic carbon dioxide is one of our most pressing global scientific challenges that may contribute to achieving a stable solution over the next several decades. Geological sequestration by injection into deep-sea basalt formations provides unique and significant advantages over other potential storage options, including: (a) vast reservoir capacities with high porosity and permeability, sufficient to accommodate centuries-long U.S. production of fossil fuel CO~2~ at locations within a few hundreds of kilometers of populated areas; (b) chemical... |
| Tipo: Poster |
Palavras-chave: Earth & Environment. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2640/version/1 |
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| Sierra Rayne; Kaya Forest. |
| A hydrometric analysis over the available historical record (1973-2010) was conducted for the Moose Jaw River station near Burdick in south-central Saskatchewan, Canada. Frequency analyses on mean monthly, average annual, monthly minimum/maximum, and annual minimum flows generally yielded poor fits, and problems with negative flow predictions for mid- to long-term return periods regardless of distribution type. The annual maximum streamflow time series is reasonably well-described by linear and log Pearson Type III distributions, although both distribution types underestimate extreme maximum flows. Mann-Kendall linear time series analysis on mean monthly and annual streamflows reveals no trend in annual water yields, nor in mean monthly flows between March... |
| Tipo: Poster |
Palavras-chave: Earth & Environment. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6697/version/1 |
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| Helena Deus. |
| Cancer is still one of the leading causes of death in the developed world. To address this problem, the US National Institutes of Health (NIH) has launched The Cancer Genome Atlas (TCGA), a large scale systematic approach to characterize tumor samples from 20 cancer types and approximately 10,000 donor patients by using multiple high-throughput approaches. 

Multidisciplinary projects such as TCGA and related projects across Europe aim at identifying cancer “driver” mutations to be used as therapeutic targets or diagnostic tests. Extracting and aggregating the knowledge necessary to identify such mutations remains a challenge primarily due to the need to reliably integrate the experimental datasets... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6169/version/1 |
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| Sierra Rayne; Kaya Forest. |
| A long-term analysis of temporal trends and frequency analyses for temperatures (1913-2010), precipitation (1909-2010), and wind speed (1954-1996) was conducted on the Moose Jaw climate station in south-central Saskatchewan, Canada. Average annual and springtime temperatures are increasing over time, as are daily mean temperatures during March. Mean daily maximum temperatures are increasing on an annual basis and during the spring period, whereas mean daily minimum temperatures are increasing during February, March, August, and September, as well as on an annual basis and during spring and summer. There are significant positive time trends for growing degree days base 8C (GDD~8~) and 10C (GDD~10~). Rainfall has been increasing during March as well as... |
| Tipo: Poster |
Palavras-chave: Earth & Environment. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6703/version/1 |
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| Saaniya Contractor; Nataliya Kozlova; Vladimir Brezina. |
| For a sensorimotor network to generate adaptive behavior in the environment, the phases of the behavior must be appropriately timed. When the behavior is driven simply by the sensory stimuli from the environment, these can supply the timing. But when the behavior is driven by an internal "goal" that ignores and perhaps even opposes the immediate sensory stimuli, the timing must be generated internally by the network. We have modeled a realistic behavioral scenario that requires such internal timing.

When the sea slug Aplysia feeds, it incrementally ingests long strips of seaweed, driven by ingestive stimuli emanating from the seaweed. But if, having ingested a strip, the animal fails to break the... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2817/version/1 |
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| Michael T. Cooling. |
| In the last decade or so, model encoding efforts such as CellML and SBML have greatly facilitated model availability. But, as the complexity of models increases, the utility of these models can vary. The addition of semantic information is crucial to transforming mathematical models from esoteric to informative resources. 

We have developed a metadata specification framework to better enable the annotation of CellML models with metadata. The framework consists of a core specification describing, in general terms, how annotations should be attached using RDF/XML, and satellite specifications covering several domains of immediate interest, using elements from the Dublin Core, FOAF (Friend-Of-A-Friend), BIBO (Bibliographic... |
| Tipo: Poster |
Palavras-chave: Molecular Cell Biology; Bioinformatics; Data Standards. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6391/version/1 |
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| Martin A. Giese; Vittorio Caggiano; Falk Fleischer. |
| SUMMARY: The recognition of actions of conspecifics is crucial for survival and social interaction. Most current models on the recognition of transitive (goal-directed) actions rely on the hypothesized role of internal motor simulations for action recognition. However, these models do not specify how visual information can be processed by cortical mechanisms in order to be compared with such motor representations. This raises the question how such visual processing might be accomplished, and in how far motor processing is critical in order to account for the visual properties of action-selective neurons.
We present a neural model for the visual processing of transient actions that is consistent with physiological data and that accomplishes... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5862/version/1 |
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| Patrick Connor; Thomas Trappenberg. |
| The striatum has long been implicated in reinforcement learning and has been suggested by several neurophysiological studies as the substrate for encoding the reward value of stimuli. Reward prediction error (RPE) has been used in several basal ganglia models as the underlying learning signal, which leads to Pavlovian conditioning abilities that can be simulated by the Rescorla-Wagner model.

Lateral inhibition between striatal projection neurons was once thought to have a winner-take-all function, useful in selecting between possible actions. However, it has been noted that the necessary reciprocal connections for this interpretation are too few, and the relative strength of these synaptic connections is weak. Still,... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5986/version/1 |
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| Günter Klambauer; Karin Schwarzbauer; Andreas Mayr; Sepp Hochreiter. |
| Next generation sequencing (NGS) are these days one of the key technologies in biology. NGS' cost effectiveness and capability of finding the smallest variations in the genome makes them increasingly popular. For studies aiming at genome assembly, differences in read count statistics do not affect the outcome. However, these differences bias the outcome if the goal is to identify structural DNA characteristics like copy number variations (CNVs). Thus a normalization step must removed such random read count variations subsequently read counts from different experiments are comparable. Especially after normalization the commonly used assumption of Poisson read count distribution in windows on the chromosomes is more justified. Strong deviations of... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Molecular Cell Biology; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4710/version/1 |
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| Günter Klambauer; Karin Schwarzbauer; Andreas Mayr; Sepp Hochreiter. |
| Next generation sequencing (NGS) are these days one of the key technologies in biology. NGS' cost effectiveness and capability of finding the smallest variations in the genome makes them increasingly popular. For studies aiming at genome assembly, differences in read count statistics do not affect the outcome. However, these differences bias the outcome if the goal is to identify structural DNA characteristics like copy number variations (CNVs). Thus a normalization step must removed such random read count variations subsequently read counts from different experiments are comparable. Especially after normalization the commonly used assumption of Poisson read count distribution in windows on the chromosomes is more justified. Strong deviations of... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Molecular Cell Biology; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4710/version/2 |
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| Bo Eskerod Madsen; Palle Villesen; Carsten Wiuf. |
| By surveying all validated SNPs in the human genome we have found that SNPs positioned 1, 2, 4, 6 or 8 bp apart are more frequent than SNPs 3, 5, 7 or 9 bp apart. This holds even when we correct for nucleotide frequencies and site dependencies in nucleotide usage in the genome. The observed pattern is not restricted to any of the genomic regions that might give sequencing or alignment errors; i.e. transposable elements (SINE, LINE and LTR), tandem repeats and large duplicated regions. However we can define periodic DNA, which virtually capture the entire pattern. Periodic DNA is defined as small DNA sequences (16.9 bp average length) with a high degree of periodicity in nucleotide usage. Periodic DNA is widely distributed in the genome, underrepresented in... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/435/version/1 |
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| Milind Watve; Gauri Tendulkar; Ketaki Ghate. |
| Plasmids are small circular DNA molecules in bacteria which replicate sharing the replication machinery with the bacterial chromosome. Since plasmids are much smaller than the chromosome, unless their replication is tightly regulated, their copy numbers can escalate quickly. A number of mechanisms of plasmid replication regulation are known in P1 plasmid of E. coli. Mechanisms such as autorepression of the replication initiator protein (RepA) and its dimerization are unable to explain copy number regulation by themselves. The number of RepA binding sites (iterons) is inversely related to copy numbers. Handcuffing of plasmids by RepA dimer is believed to be the main mechanism of arresting replication. We show here with a probabilistic model that for the... |
| Tipo: Poster |
Palavras-chave: Molecular Cell Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5421/version/1 |
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| Registros recuperados: 612 | |
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