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	Provedor de dados Nature Precedings (5) Autor Bruce R. Boynton (5) Henry L. Niman (5) Kenneth C. Earhart (5) Magdi D. Saad (5) Marshall R. Monteville (5) Mona M. Aly (5) Moustafa M. Mansour (5) Jeffery Tjaden (4) Ahmed E. Nayel (3) Ahmed S. Abdelghani (3) Ehab A. Ayoub (3) Emad M. Labib (3) Gregory A. Raczniak (3) Hala M. Esmat (3) Mensah Agyen-Frempong (3) Nasr El-Sayed (3) William K. Ampofo (3) A A. Abdelghani (2) A I. Nayei (2) A-SA Arafa (2) Mais... Palavra-chave Genetics & Genomics (5) Bioinformatics (4) Biotechnology (4) Ecology (4) Microbiology (4) Immunology (2) Chemistry (1) Evolutionary Biology (1) Mais... Tipo do documento Manuscript (5) Ano 2007 (5) País United Kingdom (5)		Registro completo Provedor de dados:  Nature Precedings País:  United Kingdom Título:  Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin Autores:  Henry L. Niman Magdi D. Saad Jeffery Tjaden Kenneth C. Earhart Marshall R. Monteville Mona M. Aly Moustafa M. Mansour Nasr El-Sayed Ahmed E. Nayel Ahmed S. Abdelghani Hala M. Esmat Emad M. Labib Ehab A. Ayoub Abdelattar Arafa Gregory A. Raczniak Mensah Agyen-Frempong William K. Ampofo Bruce R. Boynton Data:  2007-09-10 Ano:  2007 Palavras-chave:  Genetics & Genomics Evolutionary Biology Resumo:  The rapid evolution of the H5N1 serotype of avian influenza has been explained by a mechanism involving the selection of single nucleotide polymorphisms generated by copy errors. The recent emergence of H5N1 Clade 2.2 in fifty countries, offered a unique opportunity to view the acquisition of new polymorphism in these evolving genomes. We analyzed the H5N1 hemagglutinin gene from a fatal human case from Nigeria in 2007. The newly emerged polymorphisms were present in diverse H5N1 isolates from the previous year. The aggregation of these polymorphisms from clade 2.2 sub-clades was not supported by recent random mutations, and was most easily explained by recombination between closely related sequences. Tipo:  Manuscript Identificador:  http://precedings.nature.com/documents/743/version/2 oai:nature.com:10101/npre.2007.743.2 http://hdl.handle.net/10101/npre.2007.743.2 Fonte:  Nature Precedings Direitos:  Creative Commons Attribution 3.0 License Fechar

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