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Provedor de dados:  Nature Precedings
País:  United Kingdom
Título:  Polymorphisms of TSER and MTHFR are associated with prognosis of fluoropyrimidine-based therapy in colorectal cancer patients
Autores:  Jong Woo Kim
Jae Ho Lee
Seung Ho Hong
Su Jin Bae
Young Do Kwon
Doyeun Oh
Nam Keun Kim
Data:  2009-09-09
Ano:  2009
Palavras-chave:  Cancer
Genetics & Genomics
Resumo:  This study was designed to investigate the influence of TSER and MTHFR polymorphisms on the clinical outcomes of patients with colorectal cancer receiving 5-FU-based chemotherapy. Genomic DNA was isolated from 103 frozen or paraffin-embedded tissues of colorectal cancer patients. The genotypes of two common polymorphisms were determined by PCR-RFLP. Patient prognoses were compared with genotype groups and analyzed according to tumor location. Polymorphisms of TSER and MTHFR 677C>T were not significantly associated with clinicopathological factors. There were no differences in prognosis between genotypes or functional groups when the TSER and MTHFR groups were considered separately. However, analysis of combined genotypes of the TSER and the MTHFR 677C>T polymorphisms were associated with the survival rate of colorectal cancer patients who received 5-FU-based chemotherapy (p=0.028). Prognosis of colorectal cancer patients was significantly different between proximal colon and distal colon cancers (p=0.002). However, prognosis did not receive any effect of the combined genotype when analyzed according to tumor location, such as proximal and distal colon cancer. The combined TSER and MTHFR 677C>T genotypes can be prognostic factors in colorectal cancer, where gene-gene interactions between the genotypes may occur. 


Tipo:  Manuscript
Identificador:  http://precedings.nature.com/documents/3741/version/1

oai:nature.com:10101/npre.2009.3741.1

http://hdl.handle.net/10101/npre.2009.3741.1
Fonte:  Nature Precedings
Direitos:  Creative Commons Attribution 3.0 License
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