| Registro completo |
| Provedor de dados: |
Nature Precedings
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| País: |
United Kingdom
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| Título: |
Analysis of Nebivolol hydrochloride and Valsartan in Pharmaceutical Dosage Form by High Performance Thin Layer Chromatographic Method
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| Autores: |
Shradhanjali Singh
Anil K. Singh
Shanti B. Mishra
Alok Mukerjee
Mrinalini C. Damle
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| Data: |
2011-07-22
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| Ano: |
2011
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| Palavras-chave: |
Chemistry
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| Resumo: |
A simple, accurate and precise high performance thin layer chromatographic method has been developed for the estimation of Valsartan and Nebivolol hydrochloride simultaneously from a tablet dosage form. The method employed silica gel 60 F254 pre-coated plates as stationary phase and a mixture of Ethyl acetate: Methanol: Ammonia (6.5:2.5:0.5 %v/v/v) as mobile phase. Densitometric scanning was performed at 280 nm using a Camag TLC scanner 3. Beer’s law was obeyed in the concentration range of 800ng/spot-2400ng/spot for Nebivolol hydrochloride and 200ng/spot-1000ng/spot for Valsartan. The Retention factor for Nebivolol hydrochloride is 0.75 ± 0.04 and is 0.27 ± 0.01 for Valsartan . The method was validated as per ICH Guidelines, proving its utility in estimation of Valsartan and Nebivolol hydrochloride in combined dosage form.
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| Tipo: |
Manuscript
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| Identificador: |
http://precedings.nature.com/documents/6134/version/1
oai:nature.com:10.1038/npre.2011.6134.1
http://dx.doi.org/10.1038/npre.2011.6134.1
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| Fonte: |
Nature Precedings
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| Direitos: |
Creative Commons Attribution 3.0 License
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