| Registro completo |
| Provedor de dados: |
Nature Precedings
|
| País: |
United Kingdom
|
| Título: |
Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution
|
| Autores: |
Eduardo Moreno
|
| Data: |
2011-10-10
|
| Ano: |
2011
|
| Palavras-chave: |
Biotechnology
Genetics & Genomics
Evolutionary Biology
|
| Resumo: |
Here, I merge the principles of synthetic biology^1,2^ and regulatory evolution^3-11^ to create a new species^12-15^ with a minimal set of known elements. Using preexisting transgenes and recessive mutations of Drosophila melanogaster, a transgenic population arises with small eyes and a different venation pattern that fulfills the criteria of a new species according to Mayr's "Biological Species Concept"^7,10^. The genetic circuit entails the loss of a non-essential transcription factor and the introduction of cryptic enhancers. Subsequent activation of those enhancers causes hybrid lethality. The transition from "transgenic organisms" towards "synthetic species", such as Drosophila synthetica, constitutes a safety mechanism to avoid hybridization with wild type populations and preserve natural biodiversity^16-18^. Drosophila synthetica is the first transgenic organism that cannot hybridize with the original wild type population but remains fertile when crossed with other transgenic animals.
|
| Tipo: |
Manuscript
|
| Identificador: |
http://precedings.nature.com/documents/6511/version/1
oai:nature.com:10101/npre.2011.6511.1
http://hdl.handle.net/10101/npre.2011.6511.1
|
| Fonte: |
Nature Precedings
|
| Direitos: |
Creative Commons Attribution 3.0 License
|
|
