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Provedor de dados:  Inra
País:  France
Título:  Oleoyl-ethanolamide (OEA): A bioactive lipid derived from oleic acid and phosphatidylethanol-amine
Autores:  Thabuis, C.
Destaillats, F.
Tissot-Favre, D.
Martin, J.C.
Data:  2007
Ano:  2007
Palavras-chave:  ACIDE OLEIQUE
OBESITE
SATIETE
PROPRIETE BIOLOGIQUE FATTY ACID
ANOREXIC EFFECT
Resumo:  Fatty acid ethanolamides are lipid compounds with biological activities. Among them, oleoyl-ethanolamide (OEA) has attracted a great deal of interest because of its biological properties. OEA is found in low amount in foodstuffs, but mainly stems from endogenous synthesis. In rodents, intraperitoneal administration of OEA induces satiety and peripheral utilization of lipid substrate. Both in vitro studies and knock-out animal models have revealed some mechanisms of action, such as PPAR signaling, selected neuron activation and endocrine (ghrelin) signaling. The proximal intestine seems to be a target organ for satiety control. Acute oral administration also induces satiety. Further studies are still required to better address the physiological impact of both oral and intraperitoneal OEA when administrated in the long term
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20079900dee0&uri=/notices/prodinra1/2007/11/
Fonte:  Lipid Technology. 2007, 19 (10) : 225-227
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