| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
The epidemiological survey for atovaquone resistant related gene of Babesia gibsoni in Japan
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| Autores: |
Iguchi, Aiko
Soma, Takehisa
Suzuki, Hiroshi
Xuan, Xuenan
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| Data: |
2016-03
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| Ano: |
2016
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| Palavras-chave: |
Allele-specific real-time PCR
Babesia gibsoni
Drug resistance
M121I variant population
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| Resumo: |
In 73 gDNA samples from Babesia gibsoni-infected dogs, the M121I variant population was measured by using allele-specific real-time PCR. Although the mechanism of atovaquone against B. gibsoni has not been clearly identified, it is reported that the mitochondria cytochrome b gene of the atovaquone-resistant B. gibsoni had a single-nucleotide substitution at nt363 (G to T), which resulted in the substitution of methionine with isoleucine (M121I). In this study, 3/73 samples showed over 5% M121I variant population. Although the M121I variant population is a low percentage, it runs the risk of spreading drug-resistant parasites. It is important to prevent the spread of drug-resistance, so we need to gather information about this at regular intervals.
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/4421
info:doi/10.1292/jvms.15-0480
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| Editor: |
Japanese Society of Veterinary Science
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| Direitos: |
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/4.0/>.
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