| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
トキソプラズマ溶解抗原(TLA)で誘導されるマウス脾臓内の細胞障害性細胞の性質
Characteristics of Cytotoxic Cells Induced by Toxoplasma Lysate Antigen in Mouse Spleen
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| Autores: |
MIYAHARA, Kazuro
MATSUMOTO, Toru
TOSE, Shinichi
SAKURAI, Haruhisa
IGARASHI, Ikuo
SAITO, Atsushi
HIROSE, Tsuneo
SUZUKI, Naoyoshi
宮原, 和郎
五十嵐, 郁男
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| Data: |
1992
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| Ano: |
1992
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| Palavras-chave: |
Cytotoxic activity
Mouse
Phenotype
Spleen cell
Toxoplasma lysate antigen
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| Resumo: |
Spleen cells from Toxoplasma lysate antigen (TLA)-sensitized BALB/c mice showed the strong cytotoxic activity against both natural killer (NK)-sensitive cells (YAC-1 and RL♂-1) and NK-insensitive cells (P-815), when incubated with TLA or recombinant human IL-2 (rhIL-2). The increment of TLA concentration in culture medium increased the cytotoxic activity. Treatment of effector cells; spleen cells from TLA-sensitized mice incubated with TLA, with anti-asialo GM1 or anti-Thy-1 plus complement inhibited the cytotoxic activity of effector cells, whereas treatment with anti-mouse Lyt-2.2 serum plus complement had no effect on the cytotoxic activity. Treatment of spleen cells from TLA-sensitized mice with anti-asialo GM1 and/or anti-Thy-1 plus complement inhibited cytotoxic activities of effector cells. These results suggested that spleen bells sensitized with TLA both in vivo and in vitro were asialo GM1 positive and Thy-1 positive; and the majority of cytotoxic cells induced by TLA were similar to lymphokine-activated killer (LAK)cells induced by IL-2.
https://www.jstage.jst.go.jp/article/jvms1991/54/1/54_1_87/_article
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/4063
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| Editor: |
日本獣医学会
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| Direitos: |
日本獣医学会
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