| Registro completo |
| Provedor de dados: |
Organic Eprints
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| País: |
Germany
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| Título: |
Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals
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| Autores: |
Bouwman, Aniek C.
Daetwyler, Hans D.
Chamberlain, Amanda J.
Hurtado Ponce, Carla
Sargolzaei, Mehdi
Schenkel, Flavio S.
Sahana, Goutam
Govignon-Gion, Armelle
Boitard, Simon
Dolezal, Marlies
Pausch, Hubert
Brøndum, Rasmus F.
Bowman, Phil J.
Thomsen, Bo
Guldbrandtsen, Bernt
Lund, Morgns S.
Servin, Bertrand
Garrick, Dorian J.
Reecy, James
Vilkki, Johanna
Bagnato, Alessandro
Wang, Min
Hoff, Jesse L.
Schnabel, Robert D.
Taylor, Jeremy F.
Vinkhuyzen, Anna A. E.
Panitz, Frank
Bendixen, Christian
Holm, Lars-Erik
Gredler, Birgit
Hozé, Chris
Boussaha, Mekki
Sanchez, Marie-Pierre
Rocha, Dominique
Capitan, Aurelien
Tribout, Thierry
Barbat, Anne
Croiseau, Pascal
Drögemüller, Cord
Jagannathan, Vidhya
Vander Jagt, Christy
Bieber, Anna
Purfield, Deidre C.
Berry, Donagh P.
Emmerling, Reiner
Götz, Kay-Uwe
Frischknecht, Mirjam
Russ, Ingolf
Sölkner, Johann
Van Tassel, Curtis P.
Fries, Ruedi
Stothard, Paul
Veerkamp, Roel F.
Boichard, Didier
Goddard, Mike E.
Hayes, Ben J.
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| Data: |
2018
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| Ano: |
2018
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| Palavras-chave: |
Dairy cattle
Beef cattle
Breeding and genetics
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| Resumo: |
Stature is affected by many polymorphisms of small effect in humans1. In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10−8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP–seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.
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| Tipo: |
Journal paper
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| Idioma: |
Inglês
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| Identificador: |
http://orgprints.org/35102/1/Bouwman-etal-2018-NatureGenetics-Vol50-p362-367.pdf
Bouwman, Aniek C.; Daetwyler, Hans D.; Chamberlain, Amanda J.; Hurtado Ponce, Carla; Sargolzaei, Mehdi; Schenkel, Flavio S.; Sahana, Goutam; Govignon-Gion, Armelle; Boitard, Simon; Dolezal, Marlies; Pausch, Hubert; Brøndum, Rasmus F.; Bowman, Phil J.; Thomsen, Bo; Guldbrandtsen, Bernt; Lund, Morgns S.; Servin, Bertrand; Garrick, Dorian J.; Reecy, James; Vilkki, Johanna; Bagnato, Alessandro; Wang, Min; Hoff, Jesse L.; Schnabel, Robert D.; Taylor, Jeremy F.; Vinkhuyzen, Anna A. E.; Panitz, Frank; Bendixen, Christian; Holm, Lars-Erik; Gredler, Birgit; Hozé, Chris; Boussaha, Mekki; Sanchez, Marie-Pierre; Rocha, Dominique; Capitan, Aurelien; Tribout, Thierry; Barbat, Anne; Croiseau, Pascal; Drögemüller, Cord; Jagannathan, Vidhya; Vander Jagt, Christy; Bieber, Anna; Purfield, Deidre C.; Berry, Donagh P.; Emmerling, Reiner; Götz, Kay-Uwe; Frischknecht, Mirjam; Russ, Ingolf; Sölkner, Johann; Van Tassel, Curtis P.; Fries, Ruedi; Stothard, Paul; Veerkamp, Roel F.; Boichard, Didier; Goddard, Mike E. and Hayes, Ben J. (2018) Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals. Nature Genetics, 50, pp. 362-367.
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| Relação: |
http://orgprints.org/35102/
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| Formato: |
application/pdf
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