| Registro completo |
| Provedor de dados: |
Biological Sciences
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| País: |
Brazil
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| Título: |
Maternal and fetal toxicity of Wistar rats exposed to herbicide metolachlor
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| Autores: |
Tavares Vieira, Kátia Cristina de Melo
Couto, Jennifer Cardoso
Zanetti, Edson
Sanches Junior, José Marcos
Favareto, Ana Paula Alves
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| Data: |
2016-07-21
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| Ano: |
2016
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| Palavras-chave: |
Pesticide reproduction teratogenicity fetus pesticide
Reproduction
Teratogenicity
Fetus
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| Resumo: |
Metolachlor is a selective pre-emergent herbicide widely used in agriculture to control weeds. The aim of this study was to evaluate the possible effects of metolachlor on reproductive performance of adult rats, as well as its teratogenic potential when administered during the period of organogenesis. Pregnant adult female rats were allocated into 4 experimental groups (n = 10 group-1), that received 0 (control); 150 (TA); 300 (TB); or 1000 mg kg-1 bw day-1 (TC) of metolachlor, by gavage, from the 6th to 15th gestational day (GD). There is reduction in the weight gain of the animals from TB and TC groups compared to the control group. Liver and placenta weights were reduced in TB and TC groups, respectively, while the percentage of post-implantation loss was increased in the TC group. There were no external malformations in either rat of the control or treated groups. However, an increased incidence of skeletal anomalies and visceral anomalies (especially in the urogenital system) was observed in TC group. These results demonstrate that exposure of pregnant rats to metolachlor can lead to signs of general toxicity, late embryonic losses and congenital anomalies.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079
10.4025/actascibiolsci.v38i1.29079
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| Editor: |
Universidade Estadual De Maringá
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| Relação: |
http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/29079/pdf
http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/29079/10856
http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/29079/10857
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| Formato: |
application/pdf
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| Fonte: |
Acta Scientiarum. Biological Sciences; v. 38, n. 1 (2016); 91-98
Acta Scientiarum. Biological Sciences; v. 38, n. 1 (2016); 91-98
1807-863X
1679-9283
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